eukaryotic translation initiation factor 2-alpha kinase 3

 jump to detail

Synonym

HsPEK, Pancreatic eIF2-alpha kinase, PRKR-like endoplasmic reticulum kinase, PERK, PEK, EIF2AK3, DKFZp781H1925

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:19 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:30.70 spine:112.30 retina:- eye:41.10 artery/aorta:- vein:66.60 lymphnode:232.50 peripheral blood:36.40 spleen:- thymus:12.90 bone marrow:39.40 adipose:- bone:38.40 skin:9.60
GeneChip cerebrum:5.38 cerebellum:5.33 brain stem:5.55 corpus callosum/glia:5.72 pineal gland:- peripheral nerve:6.27 spine:5.90 retina:- eye:- artery/aorta:6.13 vein:5.82 lymphnode:6.83 peripheral blood:- spleen:6.61 thymus:6.40 bone marrow:5.87 adipose:6.14 bone:- skin:6.06
CAGE cerebrum:2.58 cerebellum:- brain stem:2.75 corpus callosum/glia:2.63 pineal gland:2.52 peripheral nerve:- spine:2.66 retina:- eye:- artery/aorta:3.11 vein:3.06 lymphnode:3.22 peripheral blood:- spleen:3.13 thymus:2.79 bone marrow:- adipose:3.31 bone:- skin:-
RNA-seq cerebrum:1.75 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.29 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.50 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:27.30 placenta:18.20 prostate:56.30 ovary:- testis:4.30 heart:12.80 muscle:100.50 esophagus:- stomach:21.20 intestine:64.80 colon:8.50     liver/hepato:73.90        lung:63.50    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:62.20 breast:9.30 salivary:-
GeneChip uterus:6.76 placenta:7.32 prostate:7.92 ovary:6.48 testis:5.27 heart:5.84 muscle:5.17 esophagus:6.25 stomach:7.39 intestine:6.51 colon:5.94 liver/hepato:6.34 lung:6.30 bladder:- kidney:5.31 pituitary:6.87 thyroid/parathyroid:6.91 adrenal gland:6.72 pancreas:7.55 breast:6.67 salivary:8.08
CAGE uterus:3.20 placenta:3.29 prostate:3.20 ovary:2.84 testis:2.52 heart:3.01 muscle:3.25 esophagus:2.98 stomach:- intestine:3.09 colon:2.80     liver/hepato:3.35    lung:3.23 bladder:3.80 kidney:3.11 pituitary:3.54 thyroid/parathyroid:3.23 adrenal gland:- pancreas:3.85 breast:2.91 salivary:4.20
RNA-seq uterus:- placenta:- prostate:2.98 ovary:2.80 testis:2.40 heart:1.89 muscle:2.01 esophagus:- stomach:- intestine:- colon:2.40     liver/hepato:2.09        lung:2.79    bladder:- kidney:3.34 pituitary:- thyroid/parathyroid:2.92 adrenal gland:2.57 pancreas:- breast:2.32 salivary:-

Gene Information

IDs

Refseq ID NM_004836
Gene ID 9451
Unigene ID Hs.591589
Probe set ID 218696_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000172071
GTEx ID ENSG00000172071

Orthologous Gene

Mouse[2]  NM_010121
Rat [0]  

Chromosomal Region

2p11.2  [88,856,259  -  88,927,094]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1677563
8099443
9819435
10026192
10542257
10575235
10677345
10848580
10932183
11555640
11907036
12014989
12086964
12370288
12446770
12446838
12477932
12610133
14517290
15146197
15220213
15234121
15483661
15489334
15650164
16147992
16148948
16288713
16344560
16720581
17229688
17785458
17823375
18063576
18216498
18426796
18451152
18664456
18787411
19009018
19029953
19061639
19586904
19816510
19837917
19913121
19946888
20072656
20103619
20202148
20348950
20371724
20379614
20457808
20463975
20628086
20709135
20800603
20881960
21385877
21419175
21464971
21518408
21648287
21685912
21709020
22028037
22072062
22169477
22246806
22253692
22354021
22446326
22795130
22813743
22915762
22917505
22956602
23103912
23110043
23116876
23160380
23471998
23585173
23592989
23759358
24103755
24114838
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0006987  activation of signaling protein activity involved in unfolded protein response
GO:0030282  bone mineralization
GO:0019722  calcium-mediated signaling
GO:0044267  cellular protein metabolic process
GO:0002063  chondrocyte development
GO:0031018  endocrine pancreas development
GO:0007029  endoplasmic reticulum organization
GO:0030968  endoplasmic reticulum unfolded protein response
GO:0006983  ER overload response
GO:0045444  fat cell differentiation
GO:0030073  insulin secretion
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0007595  lactation
GO:0031642  negative regulation of myelination
GO:0017148  negative regulation of translation
GO:0032057  negative regulation of translational initiation in response to stress
GO:0001503  ossification
GO:0032092  positive regulation of protein binding
GO:0009967  positive regulation of signal transduction
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0051260  protein homooligomerization
GO:0019217  regulation of fatty acid metabolic process
GO:0034976  response to endoplasmic reticulum stress
GO:0001501  skeletal system development
GO:0032933  SREBP-mediated signaling pathway
GO:0006412  translation
GO:0006926  virus-infected cell apoptosis

Cellular Component

GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0016021  integral to membrane

Molecular Function

GO:0005524  ATP binding
GO:0004694  eukaryotic translation initiation factor 2alpha kinase activity
GO:0042802  identical protein binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0019903  protein phosphatase binding
GO:0004674  protein serine/threonine kinase activity