Rho-associated, coiled-coil containing protein kinase 2

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Synonym

p164 ROCK-2, Rho-associated protein kinase 2, Rho kinase 2, KIAA0619, ROCK2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:45 cerebellum:50.40 brain stem:- corpus callosum/glia:- pineal gland:148.30 peripheral nerve:30.70 spine:112.30 retina:- eye:82.30 artery/aorta:179.90 vein:66.60 lymphnode:91 peripheral blood:- spleen:- thymus:- bone marrow:59 adipose:80.70 bone:25.60 skin:28.80
GeneChip cerebrum:7.07 cerebellum:7.61 brain stem:6.43 corpus callosum/glia:5.94 pineal gland:- peripheral nerve:6.61 spine:6.14 retina:- eye:- artery/aorta:7.30 vein:7.38 lymphnode:6.50 peripheral blood:- spleen:6.96 thymus:5.49 bone marrow:5.37 adipose:7.33 bone:- skin:6.39
CAGE cerebrum:3.32 cerebellum:- brain stem:2.84 corpus callosum/glia:2.43 pineal gland:3.06 peripheral nerve:- spine:2.46 retina:- eye:- artery/aorta:3.44 vein:2.60 lymphnode:2.53 peripheral blood:- spleen:3.19 thymus:2.30 bone marrow:- adipose:3.49 bone:- skin:-
RNA-seq cerebrum:3.62 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.44 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.50 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:82 placenta:43.70 prostate:33.80 ovary:- testis:8.70 heart:76.60 muscle:- esophagus:- stomach:63.70 intestine:32.40 colon:186.60     liver/hepato:63.30        lung:29.30    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:26.70 breast:37.20 salivary:-
GeneChip uterus:7.38 placenta:5.97 prostate:7.02 ovary:7 testis:5.25 heart:6.75 muscle:7.61 esophagus:6.31 stomach:6.69 intestine:6.63 colon:6.03 liver/hepato:7 lung:6.91 bladder:- kidney:6.27 pituitary:6.50 thyroid/parathyroid:6.70 adrenal gland:6.94 pancreas:5.14 breast:7.02 salivary:6.94
CAGE uterus:3.39 placenta:3.16 prostate:3.41 ovary:3.30 testis:2.55 heart:2.99 muscle:3.48 esophagus:3.01 stomach:- intestine:3.10 colon:3.21     liver/hepato:2.65    lung:3.22 bladder:3.70 kidney:2.62 pituitary:2.80 thyroid/parathyroid:2.61 adrenal gland:- pancreas:2.34 breast:3.54 salivary:2.31
RNA-seq uterus:- placenta:- prostate:4.38 ovary:4.15 testis:3.88 heart:3.56 muscle:3.53 esophagus:- stomach:- intestine:- colon:3.80     liver/hepato:2.24        lung:3.70    bladder:- kidney:3.47 pituitary:- thyroid/parathyroid:3.76 adrenal gland:3.51 pancreas:- breast:3.62 salivary:-

Gene Information

IDs

Refseq ID NM_004850
Gene ID 9475
Unigene ID Hs.591600
Probe set ID 202762_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000134318
GTEx ID ENSG00000134318

Orthologous Gene

Mouse[2]  NM_009072
Rat [0]  

Chromosomal Region

2p25.1  [11,319,887  -  11,488,456]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR001849  Pleckstrin homology
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR015751  Rho-associated coiled-coil containing protein kinase
IPR020684  Rho-associated coiled-coil containing protein kinase-like
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8617235
9463375
9734811
9933571
10209029
10601309
11350930
11931630
12102637
12126956
12176052
12185584
12220642
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15699075
15797222
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16574662
16585408
16964243
16996686
17012370
17015463
17081983
17137291
17167780
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17353931
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17572668
17596509
18331468
18495812
18496125
18559669
18668558
18695890
18922892
18971541
19099536
19131646
19181962
19205033
19322201
19422706
19435756
19590140
19913121
19997641
20056178
20164172
20181930
20232393
20346360
20429915
20504226
20628086
20939434
20951699
20961215
21084279
21139048
21147781
21303778
21423810
21906983
21963094
22001410
22093931
22155728
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22273145
22348083
22462535
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22798677
22842919
22863883
22939913
22942252
22986902
23211630
23326532
23328676
23479079
23615712
23644663
23789633
24036111
24065547
24135024
24168723
24608447
24674677
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0007411  axon guidance
GO:0051298  centrosome duplication
GO:0000910  cytokinesis
GO:0016525  negative regulation of angiogenesis
GO:0001843  neural tube closure
GO:0010825  positive regulation of centrosome duplication
GO:0006468  protein amino acid phosphorylation
GO:0032956  regulation of actin cytoskeleton organization
GO:0030155  regulation of cell adhesion
GO:0051893  regulation of focal adhesion formation
GO:0045616  regulation of keratinocyte differentiation
GO:0051492  regulation of stress fiber formation
GO:0006939  smooth muscle contraction

Cellular Component

GO:0005813  centrosome
GO:0005829  cytosol
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0031616  spindle pole centrosome

Molecular Function

GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity
GO:0017048  Rho GTPase binding
GO:0005198  structural molecule activity