nuclear receptor subfamily 1, group H, member 4

Synonym

RIP14, Farnesol receptor HRR-1, Farnesoid X-activated receptor, HRR1, Bile acid receptor, FXR, NR1H4, HRR-1, RXR-interacting protein 14, nuclear receptor subfamily 1, group H, member 4, Retinoid X receptor-interacting protein 14

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:9.50

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:118.60

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:3.86

cerebellum:4

brain stem:3.90

corpus callosum/glia:3.86

pineal gland:-

peripheral nerve:3.82

spine:3.96

retina:-

eye:-

artery/aorta:3.96

vein:4.06

lymphnode:4.21

peripheral blood:-

spleen:3.74

thymus:3.69

bone marrow:4.09

adipose:3.85

bone:-

skin:3.99

CAGE

cerebrum:0.07

cerebellum:-

brain stem:0

corpus callosum/glia:0.47

pineal gland:0

peripheral nerve:-

spine:0

retina:-

eye:-

artery/aorta:0.34

vein:0

lymphnode:0.97

peripheral blood:-

spleen:0.09

thymus:0

bone marrow:-

adipose:0

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:37.30

testis:4.30

heart:12.80

muscle:-

esophagus:-

stomach:-

intestine:162

colon:8.50

liver/hepato:63.30

lung:-

bladder:251.20

kidney:135.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:457.10

pancreas:-

breast:9.30

salivary:-

GeneChip

uterus:3.76

placenta:3.91

prostate:3.63

ovary:4.45

testis:3.77

heart:3.88

muscle:3.98

esophagus:3.86

stomach:3.90

intestine:4.56

colon:4.15

liver/hepato:6.72

lung:3.83

bladder:-

kidney:5.17

pituitary:4.25

thyroid/parathyroid:3.82

adrenal gland:6.07

pancreas:4.33

breast:3.85

salivary:4.28

CAGE

uterus:0.07

placenta:0.08

prostate:0.62

ovary:2.77

testis:0.04

heart:0.03

muscle:0

esophagus:0

stomach:-

intestine:3.62

colon:2.29

liver/hepato:5.23

lung:0.50

bladder:0.78

kidney:3.84

pituitary:1.47

thyroid/parathyroid:0

adrenal gland:-

pancreas:1.74

breast:0

salivary:0

RNA-seq

uterus:-

placenta:-

prostate:0

ovary:1.87

testis:0.00

heart:0

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0

liver/hepato:2.33

lung:0.00

bladder:-

kidney:0.00

pituitary:-

thyroid/parathyroid:0

adrenal gland:0.00

pancreas:-

breast:0

salivary:-

IDs

Refseq ID	NM_005123
Gene ID	9971
Unigene ID	Hs.282735
Probe set ID	206340_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000012504
GTEx ID	ENSG00000012504

Orthologous Gene

Mouse[3]	NM_001163504, NM_001163700, NM_009108
Rat [0]

Chromosomal Region

12q23.1 [100,867,486 - 100,958,191]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR003069	Ecdysteroid receptor
IPR001723	Steroid hormone receptor
IPR001728	Thyroid hormone receptor
IPR013088	Zinc finger, NHR/GATA-type
IPR001628	Zinc finger, nuclear hormone receptor-type

Gene Ontology (GO ID)

Biological Process

GO:0008206	bile acid metabolic process
GO:0071229	cellular response to acid
GO:0071417	cellular response to organic nitrogen
GO:0010467	gene expression
GO:0048565	gut development
GO:0030522	intracellular receptor-mediated signaling pathway
GO:0070858	negative regulation of bile acid biosynthetic process
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070857	regulation of bile acid biosynthetic process
GO:0006109	regulation of carbohydrate metabolic process
GO:0090181	regulation of cholesterol metabolic process
GO:0034255	regulation of urea metabolic process
GO:0009749	response to glucose stimulus
GO:0032496	response to lipopolysaccharide
GO:0007165	signal transduction
GO:0006367	transcription initiation from RNA polymerase II promoter

Cellular Component

GO:0005719	nuclear euchromatin
GO:0005654	nucleoplasm

Molecular Function

GO:0032052	bile acid binding
GO:0004879	ligand-dependent nuclear receptor activity
GO:0016922	ligand-dependent nuclear receptor binding
GO:0042277	peptide binding
GO:0005515	protein binding
GO:0046965	retinoid X receptor binding
GO:0003705	RNA polymerase II transcription factor activity, enhancer binding
GO:0043565	sequence-specific DNA binding
GO:0003707	steroid hormone receptor activity
GO:0004887	thyroid hormone receptor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0003700	transcription factor activity
GO:0008270	zinc ion binding

nuclear receptor subfamily 1, group H, member 4

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function