phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

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Synonym

AI553603, D430013K02, C030045D06Rik, RIKEN cDNA C030045D06 gene, AI316880

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.70 cerebellum:73.70 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:19.80 bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:3.74 cerebellum:- brain stem:3.13 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.26 retina:- eye:- artery/aorta:4.17 vein:- lymphnode:1.98 peripheral blood:- spleen:1.76 thymus:1.06 bone marrow:- adipose:- bone:1.02 skin:2.85
RNA-seq cerebrum:1.49 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:27.60 prostate:- ovary:103.40 testis:- heart:18.60 muscle:- esophagus:- stomach:- intestine:- colon:17.60     liver/hepato:-        lung:30.10    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:3.30 salivary:-
GeneChip nodata
CAGE uterus:2.10 placenta:1.89 prostate:0.93 ovary:2.24 testis:0 heart:- muscle:- esophagus:- stomach:1.91 intestine:1.70 colon:1.81     liver/hepato:2.53    lung:4.85 bladder:3.37 kidney:- pituitary:2.39 thyroid/parathyroid:- adrenal gland:2.54 pancreas:2.03 breast:2.51 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.64 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.68        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001033636
Gene ID 109294
Unigene ID Mm.123247
Probe set ID -
Ensembl ID ENSMUSG00000048960

Orthologous Gene

Human[2]  NM_024870, NM_025170
Rat [0]  

Chromosomal Region

1A2  [10,983,546  -  11,293,763]

Gene Family (Interpro ID)

IPR000591  DEP domain
IPR001849  Pleckstrin homology
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

10349636
10725249
10922068
11042159
11076861
11217851
12466851
12477932
12520002
14610273
15304343
15857914
16141072
16141073
18334636
20694145
21178006
21267068
23844743
24367090

Gene Ontology  (GO ID)

Biological Process

GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0032855  positive regulation of Rac GTPase activity
GO:0035023  regulation of Rho protein signal transduction

Cellular Component

GO:0005575  cellular_component

Molecular Function

GO:0005085  guanyl-nucleotide exchange factor activity
GO:0005543  phospholipid binding
GO:0030675  Rac GTPase activator activity
GO:0030676  Rac guanyl-nucleotide exchange factor activity
GO:0005089  Rho guanyl-nucleotide exchange factor activity