activin A receptor, type II-like 1

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Synonym

TSR-I, TGF-B superfamily receptor type I, Acvrlk1, ALK-1, activin A receptor, type II-like 1, activin receptor-like kinase-1, Activin receptor-like kinase 1, Alk-1, AI115505, Alk1, SKR3, AI427544, Acvrl1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:63.60 corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:- retina:32.10 eye:- artery/aorta:- vein:- lymphnode:32.40 peripheral blood:- spleen:- thymus:39.50 bone marrow:25.60 adipose:- bone:37.60 skin:79.20
GeneChip cerebrum:5.64 cerebellum:5.47 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.51 spine:5.78 retina:4.75 eye:5.36 artery/aorta:- vein:6.76 lymphnode:7.26 peripheral blood:- spleen:6.73 thymus:- bone marrow:6.66 adipose:6.91 bone:6.02 skin:5.86
CAGE cerebrum:1.29 cerebellum:- brain stem:1.41 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.85 retina:- eye:- artery/aorta:2.36 vein:- lymphnode:1.28 peripheral blood:- spleen:1.52 thymus:0.27 bone marrow:- adipose:- bone:1.97 skin:2.22
RNA-seq cerebrum:5.31 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:87.20 placenta:55.20 prostate:- ovary:11.50 testis:7.40 heart:37.20 muscle:106.50 esophagus:- stomach:- intestine:- colon:88.10     liver/hepato:18.10        lung:70.30    bladder:- kidney:8.10 pituitary:155 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:19.60 salivary:54
GeneChip uterus:7.26 placenta:8.95 prostate:6.05 ovary:6.61 testis:4.99 heart:7.15 muscle:6.97 esophagus:- stomach:6.48 intestine:6.26 colon:- liver/hepato:5.81 lung:10.53 bladder:6.89 kidney:6.34 pituitary:5.51 thyroid/parathyroid:- adrenal gland:6.02 pancreas:6.10 breast:6.61 salivary:5.88
CAGE uterus:2.74 placenta:2.76 prostate:1.51 ovary:2.27 testis:0 heart:- muscle:- esophagus:- stomach:2.16 intestine:1.70 colon:1.93     liver/hepato:0.47    lung:4.45 bladder:2.82 kidney:- pituitary:1.48 thyroid/parathyroid:- adrenal gland:2.02 pancreas:2.19 breast:2.35 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.16 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.68        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_009612
Gene ID 11482
Unigene ID Mm.279542
Probe set ID 1451604_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000000530

Orthologous Gene

Human[2]  NM_000020, NM_001077401
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7488127
7750489
9264265
9547239
10349636
10716993
11042159
11062473
11076861
11217851
12050147
12466851
12477932
12588795
12588999
12666204
12668602
12941632
12941633
12970115
14580334
14729481
15059937
15342483
15851468
15923183
15963767
16141072
16141073
16223497
16344855
16602821
16862160
17071858
17418116
17530030
17670744
17911384
17967972
18095342
18287559
18804439
18835925
19015642
19494318
19506300
19805914
19903896
20065063
20124460
20406889
20628059
21267068
21704403
21731673
21765215
21859819
22233626
22421041
22436015
22474252
22560297
22571958
22783020
23048070
23213481
23241407
23565059
23680673
23712751
23868260
24133138
24457293

Gene Ontology  (GO ID)

Biological Process

GO:0032924  activin receptor signaling pathway
GO:0001525  angiogenesis
GO:0060840  artery development
GO:0008015  blood circulation
GO:0048514  blood vessel morphogenesis
GO:0001974  blood vessel remodeling
GO:0030509  BMP signaling pathway
GO:0042118  endothelial cell activation
GO:0001701  in utero embryonic development
GO:0001946  lymphangiogenesis
GO:0060836  lymphatic endothelial cell differentiation
GO:0043537  negative regulation of blood vessel endothelial cell migration
GO:0007162  negative regulation of cell adhesion
GO:0030308  negative regulation of cell growth
GO:0030336  negative regulation of cell migration
GO:0008285  negative regulation of cell proliferation
GO:0045602  negative regulation of endothelial cell differentiation
GO:0010596  negative regulation of endothelial cell migration
GO:0001937  negative regulation of endothelial cell proliferation
GO:0051895  negative regulation of focal adhesion formation
GO:0016310  phosphorylation
GO:0030513  positive regulation of BMP signaling pathway
GO:0045603  positive regulation of endothelial cell differentiation
GO:0001938  positive regulation of endothelial cell proliferation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006468  protein amino acid phosphorylation
GO:0051291  protein heterooligomerization
GO:0008217  regulation of blood pressure
GO:0006355  regulation of transcription, DNA-dependent
GO:0007165  signal transduction
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0007178  transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0060841  venous blood vessel development
GO:0035313  wound healing, spreading of epidermal cells

Cellular Component

GO:0043025  cell soma
GO:0009986  cell surface
GO:0030425  dendrite
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane

Molecular Function

GO:0048185  activin binding
GO:0016361  activin receptor activity, type I
GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity
GO:0004702  receptor signaling protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0050431  transforming growth factor beta binding
GO:0005024  transforming growth factor beta receptor activity
GO:0005025  transforming growth factor beta receptor activity, type I
GO:0004675  transmembrane receptor protein serine/threonine kinase activity