discoidin domain receptor family, member 1

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Synonym

Ddr1, CD167a antigen, Cak, Tyrosine kinase DDR, PTK3A, Epithelial discoidin domain receptor 1, CD167a, 6030432F18, discoidin domain receptor family, member 1, Nep, Mpk6, Protein-tyrosine kinase MPK-6, Tyrosine-protein kinase CAK, Cell adhesion kinase, AI323681, Discoidin receptor tyrosine kinase, Eddr1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:211.90 cerebellum:755.20 brain stem:381.40 corpus callosum/glia:- pineal gland:- peripheral nerve:248.40 spine:803.90 retina:225 eye:281.10 artery/aorta:253.20 vein:- lymphnode:- peripheral blood:- spleen:39.50 thymus:247 bone marrow:- adipose:425.40 bone:37.60 skin:182.10
GeneChip cerebrum:6.05 cerebellum:6.28 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.04 spine:7.57 retina:5.35 eye:5.43 artery/aorta:- vein:6.18 lymphnode:5.30 peripheral blood:- spleen:5.82 thymus:- bone marrow:4.70 adipose:5.73 bone:4.68 skin:7.28
CAGE cerebrum:3.72 cerebellum:- brain stem:4.37 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.58 retina:- eye:- artery/aorta:2.82 vein:- lymphnode:1.53 peripheral blood:- spleen:1.89 thymus:2.61 bone marrow:- adipose:- bone:1.69 skin:3.97
RNA-seq cerebrum:13.99 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:218.10 placenta:220.90 prostate:- ovary:57.50 testis:96.10 heart:409.20 muscle:35.50 esophagus:- stomach:425.50 intestine:147.90 colon:141     liver/hepato:-        lung:271.10    bladder:397.10 kidney:338.50 pituitary:142.10 thyroid/parathyroid:562.40 adrenal gland:424.40 pancreas:93.80 breast:280.80 salivary:486
GeneChip uterus:7.62 placenta:7.60 prostate:7 ovary:7.19 testis:5.83 heart:5.87 muscle:5.34 esophagus:- stomach:7.44 intestine:7.27 colon:- liver/hepato:5.26 lung:5.80 bladder:5.92 kidney:7.44 pituitary:7.11 thyroid/parathyroid:- adrenal gland:5.47 pancreas:5.91 breast:6.08 salivary:5.92
CAGE uterus:3.83 placenta:4.10 prostate:4.00 ovary:3.97 testis:2.25 heart:- muscle:- esophagus:- stomach:3.85 intestine:3.63 colon:3.76     liver/hepato:0.91    lung:3.61 bladder:3.46 kidney:- pituitary:4.43 thyroid/parathyroid:- adrenal gland:3.53 pancreas:3.36 breast:3.77 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.90 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.57        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_172962
Gene ID 12305
Unigene ID Mm.5021
Probe set ID 1415798_at  [Mouse430_2]
Ensembl ID ENSMUSG00000003534

Orthologous Gene

Human[12]  NM_001202521, NM_001202523, NM_001954, NM_013993, NM_013994
Rat[6]  NM_001166022, NM_013137, NM_001954, NM_013993, NM_013994

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000421  Coagulation factor 5/8 type, C-terminal
IPR008979  Galactose-binding domain-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1281307
7558021
7774938
8127887
8302582
8397369
8530024
8622863
8889548
10349636
10970885
11042159
11076861
11114734
11217851
11254672
11283268
12065315
12397034
12466851
12477932
12904583
14610273
15200417
15226823
15782199
16141072
16141073
16167341
16602821
16603319
16690978
16783635
17093065
17113033
17210447
17658952
17969104
18026164
18287559
18451340
18799693
18836851
19007791
19401332
19834008
19893047
19900459
20093046
20307660
20448217
20576036
21267068
21289093
21344393
21499918
21640971
21947380
22019896
22751008
23335507
23382219

Gene Ontology  (GO ID)

Biological Process

GO:0060444  branching involved in mammary gland duct morphogenesis
GO:0007155  cell adhesion
GO:0043583  ear development
GO:0007566  embryo implantation
GO:0007565  female pregnancy
GO:0007595  lactation
GO:0060749  mammary gland alveolus development
GO:0008285  negative regulation of cell proliferation
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0016310  phosphorylation
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0001558  regulation of cell growth
GO:0001952  regulation of cell-matrix adhesion
GO:0010715  regulation of extracellular matrix disassembly
GO:0014909  smooth muscle cell migration
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0016323  basolateral plasma membrane
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005518  collagen binding
GO:0016301  kinase activity
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0004714  transmembrane receptor protein tyrosine kinase activity