calcium/calmodulin-dependent protein kinase II, beta

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Synonym

CaM-kinase II beta chain, CaM kinase II subunit beta, Camk2d, MGC90738, Camk2b, CaMK-II subunit beta

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:257 cerebellum:147.40 brain stem:158.90 corpus callosum/glia:- pineal gland:257.80 peripheral nerve:19.10 spine:- retina:32.10 eye:98.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:25 skin:15.80
GeneChip cerebrum:10.87 cerebellum:10.40 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.30 spine:9.31 retina:7.22 eye:5.67 artery/aorta:- vein:5.86 lymphnode:5.36 peripheral blood:- spleen:5.58 thymus:- bone marrow:5.52 adipose:6.95 bone:5.68 skin:5.94
CAGE cerebrum:6.07 cerebellum:- brain stem:5.32 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:5.09 retina:- eye:- artery/aorta:0.54 vein:- lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:- bone:3.02 skin:2.71
RNA-seq cerebrum:68.85 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:7.40 heart:- muscle:- esophagus:- stomach:- intestine:- colon:35.20     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:75.10 breast:- salivary:-
GeneChip uterus:5.61 placenta:5.26 prostate:7.75 ovary:5.57 testis:5.72 heart:6.24 muscle:8.40 esophagus:- stomach:6.31 intestine:5.96 colon:- liver/hepato:5.67 lung:5.53 bladder:5.64 kidney:5.33 pituitary:8.21 thyroid/parathyroid:- adrenal gland:7.70 pancreas:7.92 breast:6.38 salivary:5.77
CAGE uterus:0.17 placenta:0.18 prostate:0.74 ovary:0.35 testis:0.45 heart:- muscle:- esophagus:- stomach:1.07 intestine:1.05 colon:0.70     liver/hepato:0    lung:0 bladder:0.57 kidney:- pituitary:3.98 thyroid/parathyroid:- adrenal gland:2.65 pancreas:1.30 breast:0 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:5.79 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.43        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_007595
Gene ID 12323
Unigene ID Mm.439733
Probe set ID 1448676_at  [Mouse430_2]
Ensembl ID ENSMUSG00000057897

Orthologous Gene

Human[32]  NM_001220, NM_172078, NM_172079, NM_172080, NM_172081, NM_172082, NM_172083, NM_172084
Rat[5]  NM_001042354, NM_001042356, NM_021739, NM_172080, NM_172081, NM_172082, NM_172083, NM_172084

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1319776
1321343
7767000
8535974
8939850
8976376
9037549
9523577
9662407
9882483
10349636
10381553
10591541
10693762
10819240
10862698
11042159
11076861
11217851
11264466
11532017
11889801
11891785
11897160
12110572
12183685
12466851
12477932
12660151
12746302
14610273
15102471
15572359
15729571
15843557
15845548
16141072
16141073
16452087
16512683
16602821
16959763
17114649
17184923
17367784
17706588
17913888
18287559
18614564
18703025
18799693
18948074
19302145
19332541
19503086
19776387
20844140
21209221
21267068
21610080
21752990
21931829
22560297
22579289
22802532
22913516
23316062
23785157
23868268
24448406

Gene Ontology  (GO ID)

Biological Process

GO:0060466  activation of meiosis involved in egg activation
GO:0006816  calcium ion transport
GO:0030154  cell differentiation
GO:0000082  G1/S transition of mitotic cell cycle
GO:0002030  inhibitory G-protein coupled receptor phosphorylation
GO:0060291  long-term synaptic potentiation
GO:0007399  nervous system development
GO:0050885  neuromuscular process controlling balance
GO:0018105  peptidyl-serine phosphorylation
GO:0016310  phosphorylation
GO:0010976  positive regulation of neuron projection development
GO:0090129  positive regulation of synapse maturation
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0048169  regulation of long-term neuronal synaptic plasticity
GO:0032222  regulation of synaptic transmission, cholinergic
GO:0046686  response to cadmium ion

Cellular Component

GO:0005954  calcium- and calmodulin-dependent protein kinase complex
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0016020  membrane
GO:0016529  sarcoplasmic reticulum
GO:0051233  spindle midzone

Molecular Function

GO:0005524  ATP binding
GO:0005516  calmodulin binding
GO:0004683  calmodulin-dependent protein kinase activity
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups