chemokine (C-X-C motif) receptor 4

Synonym

SDF-1 receptor, Cxcr4, C-X-C chemokine receptor type 4, PB-CKR, Pre-B-cell-derived chemokine receptor, Fusin, Lestr, chemokine (C-X-C motif) receptor 4, CXCR-4, Sdf1r, Stromal cell-derived factor 1 receptor, fusin, PBSF/SDF-1, CXC-R4, CD184 antigen, Cmkar4, CD184, LESTR, CXCR4

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:74.70

cerebellum:276.30

brain stem:254.20

corpus callosum/glia:-

pineal gland:-

peripheral nerve:76.40

spine:94.60

retina:-

eye:30.40

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:9.90

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:3.96

cerebellum:3.71

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:5.28

spine:4

retina:3.87

eye:3.88

artery/aorta:-

vein:5.41

lymphnode:9.31

peripheral blood:-

spleen:9.69

thymus:-

bone marrow:10.81

adipose:4.83

bone:10.32

skin:4.24

CAGE

cerebrum:0.94

cerebellum:-

brain stem:0.94

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:1.42

retina:-

eye:-

artery/aorta:2.28

vein:-

lymphnode:5.05

peripheral blood:-

spleen:3.97

thymus:4.79

bone marrow:-

adipose:-

bone:4.81

skin:1.60

RNA-seq

cerebrum:1.04

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:7.40

heart:18.60

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:10

bladder:-

kidney:8.10

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:19.60

salivary:-

GeneChip

uterus:6.29

placenta:4.99

prostate:4.21

ovary:5.47

testis:4.22

heart:5.25

muscle:4.81

esophagus:-

stomach:4.20

intestine:4.52

colon:-

liver/hepato:3.98

lung:7.80

bladder:4.23

kidney:4.44

pituitary:4.52

thyroid/parathyroid:-

adrenal gland:10.16

pancreas:3.89

breast:6.59

salivary:4.15

CAGE

uterus:1.41

placenta:1.29

prostate:0.74

ovary:2.00

testis:0.99

heart:-

muscle:-

esophagus:-

stomach:0.67

intestine:0.58

colon:0.82

liver/hepato:0.47

lung:3.67

bladder:1.20

kidney:-

pituitary:1.40

thyroid/parathyroid:-

adrenal gland:4.57

pancreas:0.84

breast:2.03

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.98

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:0.78

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_009911
Gene ID	12767
Unigene ID	Mm.140138
Probe set ID	1448710_at [Mouse430_2]
Ensembl ID	ENSMUSG00000045382

Orthologous Gene

Human[6]	NM_001008540, NM_003467
Rat [0]

Chromosomal Region

1E4 [130,484,776 - 130,488,870]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000276	7TM GPCR, rhodopsin-like
IPR001277	C-X-C chemokine receptor, type 4
IPR000355	Chemokine receptor
IPR017452	GPCR, rhodopsin-like superfamily
IPR002286	P2 purinoceptor

Gene Ontology (GO ID)

Biological Process

GO:0001667	ameboidal cell migration
GO:0007420	brain development
GO:0019722	calcium-mediated signaling
GO:0060048	cardiac muscle contraction
GO:0016477	cell migration
GO:0070098	chemokine-mediated signaling pathway
GO:0006935	chemotaxis
GO:0002064	epithelial cell development
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0007281	germ cell development
GO:0008354	germ cell migration
GO:0008045	motor axon guidance
GO:0043217	myelin maintenance
GO:0007399	nervous system development
GO:0001764	neuron migration
GO:0042119	neutrophil activation
GO:0009887	organ morphogenesis
GO:0001569	patterning of blood vessels
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0051924	regulation of calcium ion transport
GO:0030334	regulation of cell migration
GO:0050920	regulation of chemotaxis
GO:0043067	regulation of programmed cell death
GO:0007165	signal transduction
GO:0042098	T cell proliferation
GO:0022029	telencephalon cell migration

Cellular Component

GO:0031252	cell leading edge
GO:0009986	cell surface
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0031410	cytoplasmic vesicle
GO:0005768	endosome
GO:0009897	external side of plasma membrane
GO:0030426	growth cone
GO:0016021	integral to membrane
GO:0016020	membrane
GO:0005886	plasma membrane

Molecular Function

GO:0003779	actin binding
GO:0016494	C-X-C chemokine receptor activity
GO:0004950	chemokine receptor activity
GO:0019955	cytokine binding
GO:0008144	drug binding
GO:0004930	G-protein coupled receptor activity
GO:0032027	myosin light chain binding
GO:0005515	protein binding
GO:0004871	signal transducer activity
GO:0043130	ubiquitin binding
GO:0031625	ubiquitin protein ligase binding

chemokine (C-X-C motif) receptor 4

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function