disabled homolog 2 (Drosophila)

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Synonym

AI957090, AA960054, Doc2, D15Wsu122e, Mitogen-responsive phosphoprotein, 5730435J12Rik, Dab2, p96, Disabled homolog 2, Doc-2, disabled homolog 2 (Drosophila), DOC-2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:48.60 cerebellum:165.80 brain stem:63.60 corpus callosum/glia:- pineal gland:257.80 peripheral nerve:19.10 spine:- retina:32.10 eye:38 artery/aorta:168.80 vein:- lymphnode:118.80 peripheral blood:14.40 spleen:144.80 thymus:29.60 bone marrow:141 adipose:850.90 bone:212.90 skin:71.30
GeneChip cerebrum:6.54 cerebellum:6.75 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.91 spine:6.64 retina:5.90 eye:7.11 artery/aorta:- vein:10.01 lymphnode:9.05 peripheral blood:- spleen:6.59 thymus:- bone marrow:6.54 adipose:10.16 bone:7.46 skin:7.62
CAGE cerebrum:2.98 cerebellum:- brain stem:2.99 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.71 retina:- eye:- artery/aorta:4.96 vein:- lymphnode:5.47 peripheral blood:- spleen:1.94 thymus:2.49 bone marrow:- adipose:- bone:2.83 skin:4.69
RNA-seq cerebrum:3.24 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:87.20 placenta:745.60 prostate:- ovary:218.30 testis:59.10 heart:37.20 muscle:71 esophagus:- stomach:98.20 intestine:- colon:70.50     liver/hepato:9.10        lung:100.40    bladder:198.50 kidney:491.60 pituitary:284.20 thyroid/parathyroid:112.50 adrenal gland:424.40 pancreas:9.40 breast:182.80 salivary:-
GeneChip uterus:9.25 placenta:10.56 prostate:7.50 ovary:9.87 testis:6.55 heart:9.09 muscle:8.14 esophagus:- stomach:7.35 intestine:7.01 colon:- liver/hepato:7.73 lung:9.28 bladder:9.97 kidney:12.23 pituitary:6.62 thyroid/parathyroid:- adrenal gland:11.42 pancreas:7.73 breast:9.62 salivary:7.97
CAGE uterus:4.22 placenta:4.47 prostate:2.88 ovary:4.75 testis:2.85 heart:- muscle:- esophagus:- stomach:3.91 intestine:2.54 colon:2.53     liver/hepato:3.36    lung:4.28 bladder:4.75 kidney:- pituitary:2.89 thyroid/parathyroid:- adrenal gland:6.52 pancreas:3.97 breast:6.34 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.93 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.13        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_023118
Gene ID 13132
Unigene ID Mm.240830
Probe set ID 1420498_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000022150

Orthologous Gene

Human[4]  NM_001343
Rat [0]  

Chromosomal Region

15A1  [6,249,788  -  6,390,712]

Gene Family (Interpro ID)

IPR006020  Phosphotyrosine interaction domain
IPR011993  Pleckstrin homology-type

Link to Pubmed  (Pubmed ID)

7775479
8889548
9569023
9811942
10340473
10349636
10488064
10725249
10779506
10922068
10944463
11042159
11076861
11104669
11217851
11247302
11368898
11823414
11906161
11927540
11967127
12040188
12234931
12413896
12466851
12477932
12805222
12826668
14596919
14660441
15489334
15592455
15596140
15734730
15769480
15870384
15894542
16109395
16141072
16141073
16263760
16602821
16629596
16678776
16816378
16887818
16984970
17182866
17317100
17339320
17671122
17762867
18083160
18680569
18725515
18816845
19191217
19191218
19521566
19581412
19581931
19767570
19850877
20154680
20351096
20881059
20925113
21146513
21677750
22323290
22411869
22491013
22525672
22581778
22648170
23354168
24168030
24457600
24846918

Gene Ontology  (GO ID)

Biological Process

GO:0007257  activation of JUN kinase activity
GO:0006915  apoptosis
GO:0030154  cell differentiation
GO:0000904  cell morphogenesis involved in differentiation
GO:0071364  cellular response to epidermal growth factor stimulus
GO:0048268  clathrin coat assembly
GO:0006897  endocytosis
GO:0007492  endoderm development
GO:0007588  excretion
GO:0001701  in utero embryonic development
GO:0007275  multicellular organismal development
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0030308  negative regulation of cell growth
GO:0050680  negative regulation of epithelial cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0010977  negative regulation of neuron projection development
GO:0032091  negative regulation of protein binding
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0006907  pinocytosis
GO:0032349  positive regulation of aldosterone biosynthetic process
GO:0045785  positive regulation of cell adhesion
GO:0030335  positive regulation of cell migration
GO:0045807  positive regulation of endocytosis
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0001921  positive regulation of receptor recycling
GO:0032968  positive regulation of RNA elongation from RNA polymerase II promoter
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0015031  protein transport
GO:0006898  receptor-mediated endocytosis
GO:0048545  response to steroid hormone stimulus
GO:0006810  transport
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0016324  apical plasma membrane
GO:0030132  clathrin coat of coated pit
GO:0030665  clathrin coated vesicle membrane
GO:0005905  coated pit
GO:0005737  cytoplasm
GO:0031410  cytoplasmic vesicle
GO:0016020  membrane
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0070022  transforming growth factor beta receptor complex

Molecular Function

GO:0030276  clathrin binding
GO:0005178  integrin binding
GO:0005546  phosphatidylinositol-4,5-bisphosphate binding
GO:0035091  phosphoinositide binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0046332  SMAD binding