DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked

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Synonym

D1Pas1-related sequence 2, Erh, mDEAD3, D1Pas1-rs2, embryonic RNA helicase, Ddx3, Fin14, ATP-dependent RNA helicase DDX3X, Embryonic RNA helicase, DEAD box RNA helicase DEAD3, Dead3, Ddx3x, DEAD box protein 3, X-chromosomal

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:340.40 cerebellum:165.80 brain stem:31.80 corpus callosum/glia:- pineal gland:515.60 peripheral nerve:496.80 spine:189.10 retina:610.70 eye:341.90 artery/aorta:- vein:- lymphnode:43.20 peripheral blood:1437.70 spleen:329.20 thymus:177.80 bone marrow:51.30 adipose:638.20 bone:150.30 skin:332.50
GeneChip cerebrum:11.03 cerebellum:11.61 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:11.61 spine:10.84 retina:10.21 eye:10.10 artery/aorta:- vein:11.92 lymphnode:11.93 peripheral blood:- spleen:11.37 thymus:- bone marrow:11.64 adipose:11.36 bone:11.68 skin:11.93
CAGE cerebrum:3.43 cerebellum:- brain stem:3.39 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.64 retina:- eye:- artery/aorta:4.05 vein:- lymphnode:4.44 peripheral blood:- spleen:3.15 thymus:3.61 bone marrow:- adipose:- bone:3.38 skin:4.32
RNA-seq cerebrum:3.53 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:261.70 placenta:193.30 prostate:61.80 ovary:1114.60 testis:509.90 heart:93 muscle:106.50 esophagus:- stomach:163.60 intestine:73.90 colon:123.40     liver/hepato:63.40        lung:291.20    bladder:198.50 kidney:233.70 pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:215.80 breast:463.60 salivary:-
GeneChip uterus:11.94 placenta:11.96 prostate:11.50 ovary:12.27 testis:8.12 heart:10.93 muscle:11.38 esophagus:- stomach:11.47 intestine:11.64 colon:- liver/hepato:11.14 lung:11.76 bladder:11.86 kidney:11.02 pituitary:11.40 thyroid/parathyroid:- adrenal gland:12.39 pancreas:11.37 breast:11.88 salivary:12.53
CAGE uterus:3.44 placenta:4.12 prostate:3.43 ovary:3.66 testis:2.05 heart:- muscle:- esophagus:- stomach:3.00 intestine:3.45 colon:3.51     liver/hepato:4.05    lung:3.49 bladder:3.37 kidney:- pituitary:3.38 thyroid/parathyroid:- adrenal gland:3.64 pancreas:3.77 breast:4.09 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:6.89 esophagus:- stomach:- intestine:- colon:-     liver/hepato:12.49        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010028
Gene ID 13205
Unigene ID Mm.289662
Probe set ID 1423043_s_at  [Mouse430_2]
Ensembl ID ENSMUSG00000000787

Orthologous Gene

Human[4]  NM_001193416, NM_001193417, NM_001356
Rat[1]  NM_001108858, NM_001108246, NM_001356

Chromosomal Region

-

Gene Family (Interpro ID)

IPR014001  DEAD-like helicase, N-terminal
IPR014021  Helicase, superfamily 1/2, ATP-binding domain

Link to Pubmed  (Pubmed ID)

8144024
8649829
8661741
8948440
9021147
9693046
10349636
10859333
10922068
11042159
11076861
11217851
12023983
12466851
12477932
12904583
14681479
14729942
15782199
16107646
16141072
16141073
16728723
18495661
18583960
19571810
21267068
21471155
22566683
22573614
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0006200  ATP catabolic process
GO:0071243  cellular response to arsenic
GO:0071470  cellular response to osmotic stress
GO:0007059  chromosome segregation
GO:0008625  induction of apoptosis via death domain receptors
GO:0045087  innate immune response
GO:0042256  mature ribosome assembly
GO:0008152  metabolic process
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0030308  negative regulation of cell growth
GO:0031333  negative regulation of protein complex assembly
GO:0017148  negative regulation of translation
GO:0043065  positive regulation of apoptosis
GO:0043280  positive regulation of caspase activity
GO:0030307  positive regulation of cell growth
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045727  positive regulation of translation
GO:0045948  positive regulation of translational initiation
GO:0007243  protein kinase cascade
GO:0006355  regulation of transcription, DNA-dependent
GO:0006417  regulation of translation
GO:0009615  response to virus
GO:0042254  ribosome biogenesis
GO:0010501  RNA secondary structure unwinding
GO:0034063  stress granule assembly
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0022627  cytosolic small ribosomal subunit
GO:0005852  eukaryotic translation initiation factor 3 complex
GO:0016020  membrane
GO:0005741  mitochondrial outer membrane
GO:0005739  mitochondrion
GO:0005634  nucleus
GO:0010494  stress granule

Molecular Function

GO:0005524  ATP binding
GO:0004003  ATP-dependent DNA helicase activity
GO:0008026  ATP-dependent helicase activity
GO:0004004  ATP-dependent RNA helicase activity
GO:0016887  ATPase activity
GO:0003677  DNA binding
GO:0008190  eukaryotic initiation factor 4E binding
GO:0004386  helicase activity
GO:0016787  hydrolase activity
GO:0048027  mRNA 5'-UTR binding
GO:0003676  nucleic acid binding
GO:0000166  nucleotide binding
GO:0008143  poly(A) RNA binding
GO:0043024  ribosomal small subunit binding
GO:0003723  RNA binding
GO:0008134  transcription factor binding
GO:0031369  translation initiation factor binding