DEAD (Asp-Glu-Ala-Asp) box polypeptide 5

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Synonym

Probable ATP-dependent RNA helicase DDX5, 2600009A06Rik, HUMP68, Hlr1, MGC118083, RNA helicase p68, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5, mDEAD1, Tnz2, G17P1, DEAD box protein 5, Ddx5, DEAD box RNA helicase DEAD1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:409.80 cerebellum:239.50 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:382.20 spine:331 retina:867.90 eye:911.80 artery/aorta:- vein:- lymphnode:108 peripheral blood:2573.50 spleen:539.80 thymus:177.80 bone marrow:564.10 adipose:212.70 bone:400.80 skin:578
GeneChip cerebrum:12.14 cerebellum:12.74 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:11.14 spine:10.82 retina:11.64 eye:10.74 artery/aorta:- vein:11.03 lymphnode:12.31 peripheral blood:- spleen:12.14 thymus:- bone marrow:11.43 adipose:10.51 bone:11.60 skin:12.02
CAGE cerebrum:0.63 cerebellum:- brain stem:0.38 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.66 retina:- eye:- artery/aorta:0.70 vein:- lymphnode:0.42 peripheral blood:- spleen:0.62 thymus:0.67 bone marrow:- adipose:- bone:1.02 skin:0.15
RNA-seq cerebrum:26.27 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:1134.20 placenta:345.20 prostate:463.20 ovary:517.10 testis:679.80 heart:372 muscle:142 esophagus:- stomach:654.60 intestine:184.90 colon:405.30     liver/hepato:253.40        lung:1114.70    bladder:198.50 kidney:636.70 pituitary:452.10 thyroid/parathyroid:899.80 adrenal gland:1697.80 pancreas:431.60 breast:741.10 salivary:216
GeneChip uterus:11.93 placenta:10.27 prostate:12.06 ovary:11.77 testis:9.08 heart:9.51 muscle:10.80 esophagus:- stomach:11.11 intestine:11.34 colon:- liver/hepato:10.65 lung:11.78 bladder:11.41 kidney:10.55 pituitary:12.05 thyroid/parathyroid:- adrenal gland:12.05 pancreas:10.11 breast:11.20 salivary:11.42
CAGE uterus:0.90 placenta:0.47 prostate:0.93 ovary:0.62 testis:0.45 heart:- muscle:- esophagus:- stomach:2.26 intestine:0.23 colon:0     liver/hepato:1.12    lung:0.83 bladder:0.93 kidney:- pituitary:1.22 thyroid/parathyroid:- adrenal gland:0.78 pancreas:0.84 breast:0.42 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:19.42 esophagus:- stomach:- intestine:- colon:-     liver/hepato:17.54        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_007840
Gene ID 13207
Unigene ID Mm.220038
Probe set ID 1423645_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000020719

Orthologous Gene

Human[1]  NM_004396
Rat[1]  NM_001007613

Chromosomal Region

-

Gene Family (Interpro ID)

IPR014001  DEAD-like helicase, N-terminal
IPR014021  Helicase, superfamily 1/2, ATP-binding domain

Link to Pubmed  (Pubmed ID)

2762324
7729546
8088835
8144024
8445986
8631027
9034148
9600738
9811942
10349636
10464095
10922068
11042159
11076861
11217851
12456657
12466851
12477932
12520002
12904583
14610273
14681479
15304501
15464984
15657085
15782199
16141072
16141073
16416089
16568498
16595651
16602821
17011493
17435748
17960593
17967808
18005418
18495661
18799693
18809582
19025768
19340935
19723804
19786986
19892877
20966046
21677750
21937682
22266867
22354994
22359951
22454253
22570411
22665494
22767893
22986526
23029089
23086144
23180766
23396200
23649778
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0006200  ATP catabolic process
GO:0007623  circadian rhythm
GO:0001701  in utero embryonic development
GO:0006397  mRNA processing
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0043517  positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0033148  positive regulation of estrogen receptor signaling pathway
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0000381  regulation of alternative nuclear mRNA splicing, via spliceosome
GO:0060765  regulation of androgen receptor signaling pathway
GO:0045667  regulation of osteoblast differentiation
GO:0006355  regulation of transcription, DNA-dependent
GO:0045069  regulation of viral genome replication
GO:0008380  RNA splicing
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0071013  catalytic step 2 spliceosome
GO:0005634  nucleus
GO:0030529  ribonucleoprotein complex
GO:0005681  spliceosomal complex

Molecular Function

GO:0050681  androgen receptor binding
GO:0005524  ATP binding
GO:0008026  ATP-dependent helicase activity
GO:0004004  ATP-dependent RNA helicase activity
GO:0048306  calcium-dependent protein binding
GO:0005516  calmodulin binding
GO:0019899  enzyme binding
GO:0030331  estrogen receptor binding
GO:0004386  helicase activity
GO:0016787  hydrolase activity
GO:0016818  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0003676  nucleic acid binding
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0003723  RNA binding
GO:0003724  RNA helicase activity
GO:0003713  transcription coactivator activity
GO:0003712  transcription cofactor activity