eukaryotic translation initiation factor 2 alpha kinase 3

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Synonym

Perk, PEK, AI427929, Pancreatic eIF2-alpha kinase, PRKR-like endoplasmic reticulum kinase, Pek, perk, Eif2ak3

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:33

cerebellum:18.40

brain stem:63.60

corpus callosum/glia:-

pineal gland:-

peripheral nerve:19.10

spine:-

retina:-

eye:68.40

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:100.60

spleen:-

thymus:49.40

bone marrow:25.60

adipose:-

bone:37.60

skin:39.60

GeneChip

cerebrum:8.05

cerebellum:8.74

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:9.18

spine:8.33

retina:8.65

eye:7.79

artery/aorta:-

vein:8.84

lymphnode:9.61

peripheral blood:-

spleen:9.48

thymus:-

bone marrow:9.30

adipose:8.15

bone:9.03

skin:8.25

CAGE

cerebrum:3.12

cerebellum:-

brain stem:2.94

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:3.10

retina:-

eye:-

artery/aorta:2.90

vein:-

lymphnode:2.90

peripheral blood:-

spleen:3.23

thymus:3.71

bone marrow:-

adipose:-

bone:3.28

skin:2.99

RNA-seq

cerebrum:4.06

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:27.60

prostate:61.80

ovary:23

testis:7.40

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:17.60

liver/hepato:18.10

lung:10

bladder:-

kidney:-

pituitary:12.90

thyroid/parathyroid:112.50

adrenal gland:-

pancreas:159.50

breast:29.40

salivary:54

GeneChip

uterus:8.70

placenta:9.75

prostate:10.45

ovary:8.51

testis:6.20

heart:7.05

muscle:7.38

esophagus:-

stomach:9.24

intestine:9.35

colon:-

liver/hepato:8.26

lung:8.89

bladder:8.55

kidney:8.70

pituitary:9.70

thyroid/parathyroid:-

adrenal gland:8.45

pancreas:10.47

breast:8.45

salivary:10.19

CAGE

uterus:2.98

placenta:3.57

prostate:4.10

ovary:3.10

testis:0.75

heart:-

muscle:-

esophagus:-

stomach:3.51

intestine:3.50

colon:3.55

liver/hepato:2.90

lung:3.36

bladder:2.90

kidney:-

pituitary:3.95

thyroid/parathyroid:-

adrenal gland:3.20

pancreas:5.24

breast:3.45

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.67

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:3.02

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_010121
Gene ID	13666
Unigene ID	Mm.247167
Probe set ID	1449278_at [Mouse430_2]
Ensembl ID	ENSMUSG00000031668

Orthologous Gene

Human[1]	NM_004836
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0070059	apoptosis in response to endoplasmic reticulum stress
GO:0030282	bone mineralization
GO:0019722	calcium-mediated signaling
GO:0002063	chondrocyte development
GO:0031018	endocrine pancreas development
GO:0007029	endoplasmic reticulum organization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0006983	ER overload response
GO:0045444	fat cell differentiation
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0007595	lactation
GO:0031642	negative regulation of myelination
GO:0017148	negative regulation of translation
GO:0032055	negative regulation of translation in response to stress
GO:0001503	ossification
GO:0031016	pancreas development
GO:0016310	phosphorylation
GO:0032092	positive regulation of protein binding
GO:0009967	positive regulation of signal transduction
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0051260	protein homooligomerization
GO:0019217	regulation of fatty acid metabolic process
GO:0006417	regulation of translation
GO:0034976	response to endoplasmic reticulum stress
GO:0006950	response to stress
GO:0006986	response to unfolded protein
GO:0001501	skeletal system development
GO:0032933	SREBP-mediated signaling pathway
GO:0006412	translation
GO:0006413	translational initiation
GO:0006926	virus-infected cell apoptosis

Cellular Component

GO:0005623	cell
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral to membrane
GO:0016020	membrane

Molecular Function

GO:0005524	ATP binding
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity
GO:0042802	identical protein binding
GO:0016301	kinase activity
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0019903	protein phosphatase binding
GO:0004674	protein serine/threonine kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0003743	translation initiation factor activity

eukaryotic translation initiation factor 2 alpha kinase 3

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function