endoglin

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Synonym

CD105, Eng, Endoglin precursor, AI528660, Edg, Cell surface MJ7/18 antigen, endoglin, S-endoglin

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:36.50

cerebellum:18.40

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:76.40

spine:94.60

retina:-

eye:15.20

artery/aorta:-

vein:-

lymphnode:21.60

peripheral blood:258.80

spleen:131.70

thymus:9.90

bone marrow:115.40

adipose:-

bone:300.60

skin:190

GeneChip

cerebrum:7.91

cerebellum:8.03

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:7.51

spine:8.44

retina:7.57

eye:7.77

artery/aorta:-

vein:8.54

lymphnode:9.28

peripheral blood:-

spleen:9.55

thymus:-

bone marrow:8.54

adipose:8.82

bone:8.32

skin:7.83

CAGE

cerebrum:3.44

cerebellum:-

brain stem:3.87

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:3.90

retina:-

eye:-

artery/aorta:5.21

vein:-

lymphnode:4.84

peripheral blood:-

spleen:4.57

thymus:2.95

bone marrow:-

adipose:-

bone:3.87

skin:3.87

RNA-seq

cerebrum:6.13

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:218.10

placenta:69

prostate:-

ovary:11.50

testis:-

heart:148.80

muscle:106.50

esophagus:-

stomach:32.70

intestine:-

colon:123.40

liver/hepato:90.50

lung:281.20

bladder:-

kidney:129

pituitary:38.80

thyroid/parathyroid:224.90

adrenal gland:-

pancreas:28.10

breast:65.30

salivary:54

GeneChip

uterus:9.18

placenta:8.52

prostate:8.06

ovary:9.01

testis:7.62

heart:10.03

muscle:9.24

esophagus:-

stomach:8.50

intestine:8.07

colon:-

liver/hepato:9.24

lung:11.40

bladder:8.49

kidney:9.39

pituitary:8.46

thyroid/parathyroid:-

adrenal gland:9.36

pancreas:8.86

breast:8.82

salivary:8.22

CAGE

uterus:4.48

placenta:4.70

prostate:2.88

ovary:4.59

testis:0.45

heart:-

muscle:-

esophagus:-

stomach:4.20

intestine:3.56

colon:3.65

liver/hepato:5.03

lung:6.51

bladder:4.30

kidney:-

pituitary:3.97

thyroid/parathyroid:-

adrenal gland:5.00

pancreas:4.08

breast:4.24

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:5.53

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:14.92

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_007932
Gene ID	13805
Unigene ID	Mm.225297
Probe set ID	1417271_a_at [Mouse430_2]
Ensembl ID	ENSMUSG00000026814

Orthologous Gene

Human[4]	NM_000118, NM_001114753
Rat[4]	NM_000118, NM_001114753

Chromosomal Region

2B [32,502,115 - 32,538,189]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001507

Endoglin/CD105 antigen

Gene Ontology (GO ID)

Biological Process

GO:0001525	angiogenesis
GO:0048844	artery morphogenesis
GO:0007155	cell adhesion
GO:0060326	cell chemotaxis
GO:0016477	cell migration
GO:0003273	cell migration involved in endocardial cushion formation
GO:0048870	cell motility
GO:0022009	central nervous system vasculogenesis
GO:0070483	detection of hypoxia
GO:0022617	extracellular matrix disassembly
GO:0007507	heart development
GO:0001947	heart looping
GO:0030336	negative regulation of cell migration
GO:0001937	negative regulation of endothelial cell proliferation
GO:0051001	negative regulation of nitric-oxide synthase activity
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0031953	negative regulation of protein amino acid autophosphorylation
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001569	patterning of blood vessels
GO:0045766	positive regulation of angiogenesis
GO:0030513	positive regulation of BMP signaling pathway
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-dependent
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0001666	response to hypoxia
GO:0048745	smooth muscle tissue development
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0001570	vasculogenesis
GO:0048845	venous blood vessel morphogenesis
GO:0042060	wound healing

Cellular Component

GO:0009986	cell surface
GO:0005737	cytoplasm
GO:0009897	external side of plasma membrane
GO:0005615	extracellular space
GO:0016021	integral to membrane
GO:0016020	membrane
GO:0005634	nucleus

Molecular Function

GO:0005534	galactose binding
GO:0005539	glycosaminoglycan binding
GO:0042803	protein homodimerization activity
GO:0050431	transforming growth factor beta binding
GO:0005024	transforming growth factor beta receptor activity
GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0034713	type I transforming growth factor beta receptor binding
GO:0005114	type II transforming growth factor beta receptor binding

endoglin

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function