Eph receptor A7

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Synonym

Tyrosine-protein kinase receptor EHK-3, Ebk, Cek11, Ephrin type-A receptor 7 precursor, Eph receptor A7, Ehk3, EPH homology kinase 3, MDK1, Epha7, MDK-1, Developmental kinase 1, Hek11, EBK, Embryonic brain kinase, Mdk1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:76.40 cerebellum:55.30 brain stem:63.60 corpus callosum/glia:- pineal gland:- peripheral nerve:76.40 spine:47.30 retina:- eye:22.80 artery/aorta:- vein:- lymphnode:- peripheral blood:28.80 spleen:- thymus:9.90 bone marrow:- adipose:- bone:- skin:110.80
GeneChip cerebrum:7.79 cerebellum:5.88 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.75 spine:5.13 retina:4.99 eye:4.68 artery/aorta:- vein:6.02 lymphnode:4.61 peripheral blood:- spleen:4.46 thymus:- bone marrow:4.49 adipose:4.71 bone:4.68 skin:4.55
CAGE cerebrum:4.45 cerebellum:- brain stem:3.63 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.82 retina:- eye:- artery/aorta:1.11 vein:- lymphnode:0.57 peripheral blood:- spleen:0.41 thymus:0 bone marrow:- adipose:- bone:0 skin:1.03
RNA-seq cerebrum:3.05 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:87.20 placenta:13.80 prostate:- ovary:11.50 testis:44.30 heart:18.60 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:30.10    bladder:- kidney:8.10 pituitary:219.60 thyroid/parathyroid:- adrenal gland:- pancreas:56.30 breast:13.10 salivary:-
GeneChip uterus:5.03 placenta:4.73 prostate:4.77 ovary:4.59 testis:5.27 heart:5.16 muscle:4.94 esophagus:- stomach:5.05 intestine:5.39 colon:- liver/hepato:4.60 lung:5.01 bladder:5.12 kidney:4.89 pituitary:5.34 thyroid/parathyroid:- adrenal gland:4.90 pancreas:5.13 breast:4.80 salivary:4.85
CAGE uterus:2.14 placenta:0.87 prostate:0.93 ovary:2.14 testis:0.75 heart:- muscle:- esophagus:- stomach:1.07 intestine:1.43 colon:1.77     liver/hepato:1.75    lung:2.85 bladder:2.50 kidney:- pituitary:2.98 thyroid/parathyroid:- adrenal gland:1.67 pancreas:3.04 breast:1.51 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.04 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.68        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001122889
Gene ID 13841
Unigene ID Mm.257266
Probe set ID 1427528_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000028289

Orthologous Gene

Human[1]  NM_004440
Rat [0]  

Chromosomal Region

4A4  [28,740,281  -  28,894,649]

Gene Family (Interpro ID)

IPR001090  Ephrin receptor, ligand binding
IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR008979  Galactose-binding domain-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001660  Sterile alpha motif
IPR010993  Sterile alpha motif homology
IPR013761  Sterile alpha motif-type
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR016257  Tyrosine-protein kinase, ephrin receptor
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7824284
8302608
8541219
8750872
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9010230
9267020
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23425387
23623550
23657875
23658181
23831966
24036135
24038871
24574009
24707048

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0007420  brain development
GO:0048755  branching morphogenesis of a nerve
GO:0048013  ephrin receptor signaling pathway
GO:0007275  multicellular organismal development
GO:0050919  negative chemotaxis
GO:0007399  nervous system development
GO:0016310  phosphorylation
GO:0043065  positive regulation of apoptosis
GO:0043525  positive regulation of neuron apoptosis
GO:0006468  protein amino acid phosphorylation
GO:0043281  regulation of caspase activity
GO:0022407  regulation of cell-cell adhesion
GO:0070372  regulation of ERK1 and ERK2 cascade
GO:0050730  regulation of peptidyl-tyrosine phosphorylation
GO:0031952  regulation of protein amino acid autophosphorylation
GO:0031290  retinal ganglion cell axon guidance
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0043025  cell soma
GO:0030425  dendrite
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0031594  neuromuscular junction
GO:0005886  plasma membrane
GO:0045211  postsynaptic membrane

Molecular Function

GO:0005524  ATP binding
GO:0008046  axon guidance receptor activity
GO:0045499  chemorepellent activity
GO:0005003  ephrin receptor activity
GO:0046875  ephrin receptor binding
GO:0005004  GPI-linked ephrin receptor activity
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0004714  transmembrane receptor protein tyrosine kinase activity