excision repair cross-complementing rodent repair deficiency, complementation group 2

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Synonym

DNA excision repair protein ERCC-2, CXPD, Ercc-2, AU020867, XPD, Xpd, AW240756, Ercc2, AA407812, DNA-repair protein complementing XP-D cells

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:50.40 cerebellum:92.10 brain stem:222.50 corpus callosum/glia:- pineal gland:515.60 peripheral nerve:76.40 spine:47.30 retina:64.30 eye:91.20 artery/aorta:84.40 vein:- lymphnode:32.40 peripheral blood:115 spleen:210.70 thymus:118.60 bone marrow:- adipose:212.70 bone:25 skin:63.30
GeneChip cerebrum:7.13 cerebellum:7.25 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.90 spine:7.27 retina:7.18 eye:6.94 artery/aorta:- vein:6.96 lymphnode:7.13 peripheral blood:- spleen:7.56 thymus:- bone marrow:7.36 adipose:6.92 bone:7.04 skin:6.88
CAGE cerebrum:2.61 cerebellum:- brain stem:2.44 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.68 retina:- eye:- artery/aorta:2.16 vein:- lymphnode:2.41 peripheral blood:- spleen:2.10 thymus:2.61 bone marrow:- adipose:- bone:2.09 skin:2.05
RNA-seq cerebrum:4.15 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:82.80 prostate:- ovary:23 testis:29.60 heart:18.60 muscle:35.50 esophagus:- stomach:- intestine:37 colon:35.20     liver/hepato:18.10        lung:90.40    bladder:- kidney:32.20 pituitary:219.60 thyroid/parathyroid:- adrenal gland:- pancreas:9.40 breast:42.40 salivary:-
GeneChip uterus:7.35 placenta:7.20 prostate:7.13 ovary:7.19 testis:7.82 heart:7.03 muscle:6.83 esophagus:- stomach:7.26 intestine:7.15 colon:- liver/hepato:7.50 lung:6.79 bladder:6.90 kidney:7.18 pituitary:7.67 thyroid/parathyroid:- adrenal gland:6.87 pancreas:7.74 breast:7 salivary:7.31
CAGE uterus:2.40 placenta:2.29 prostate:2.47 ovary:2.38 testis:3.50 heart:- muscle:- esophagus:- stomach:2.04 intestine:1.75 colon:2.30     liver/hepato:1.94    lung:2.29 bladder:2.21 kidney:- pituitary:2.95 thyroid/parathyroid:- adrenal gland:2.31 pancreas:2.33 breast:2.85 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.35 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.41        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_007949
Gene ID 13871
Unigene ID Mm.36524
Probe set ID 1460727_at  [Mouse430_2]
Ensembl ID ENSMUSG00000030400

Orthologous Gene

Human[2]  NM_000400, NM_001130867
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR010614  DEAD2
IPR013020  DNA helicase (DNA repair), Rad3 type
IPR014013  Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR006554  Helicase-like, DEXD box c2 type
IPR001945  Xeroderma pigmentosum group D protein

Link to Pubmed  (Pubmed ID)

984047
1486805
1638085
1981054
2307474
2558854
2835663
8786141
8889548
9426063
9607915
9651581
9811942
10349636
10416615
10725249
10843671
10922068
11042159
11076861
11156600
11217851
11950998
12466851
12477932
14980221
15226823
15782199
15988019
16115803
16141072
16141073
16472827
16602821
16904611
17020410
17173483
17276355
17554309
17952069
18545656
19114557
19406934
20059953
21267068
21677750
22174697
22506075
22705887
22863773
23046824
23562818

Gene Ontology  (GO ID)

Biological Process

GO:0007568  aging
GO:0030282  bone mineralization
GO:0000075  cell cycle checkpoint
GO:0008283  cell proliferation
GO:0007059  chromosome segregation
GO:0006281  DNA repair
GO:0040016  embryonic cleavage
GO:0043249  erythrocyte maturation
GO:0030198  extracellular matrix organization
GO:0035315  hair cell differentiation
GO:0022405  hair cycle process
GO:0048820  hair follicle maturation
GO:0060218  hemopoietic stem cell differentiation
GO:0001701  in utero embryonic development
GO:0006917  induction of apoptosis
GO:0035264  multicellular organism growth
GO:0032289  myelin formation in the central nervous system
GO:0006139  nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0006289  nucleotide-excision repair
GO:0033683  nucleotide-excision repair, DNA incision
GO:0043388  positive regulation of DNA binding
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0009791  post-embryonic development
GO:0006468  protein amino acid phosphorylation
GO:0006355  regulation of transcription, DNA-dependent
GO:0006974  response to DNA damage stimulus
GO:0006979  response to oxidative stress
GO:0009411  response to UV
GO:0043588  skin development
GO:0021510  spinal cord development
GO:0006366  transcription from RNA polymerase II promoter
GO:0006351  transcription, DNA-dependent
GO:0006283  transcription-coupled nucleotide-excision repair
GO:0009650  UV protection

Cellular Component

GO:0019907  cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005675  holo TFIIH complex
GO:0005634  nucleus
GO:0005819  spindle

Molecular Function

GO:0051539  4 iron, 4 sulfur cluster binding
GO:0043139  5'-3' DNA helicase activity
GO:0005524  ATP binding
GO:0004003  ATP-dependent DNA helicase activity
GO:0008026  ATP-dependent helicase activity
GO:0003677  DNA binding
GO:0008094  DNA-dependent ATPase activity
GO:0004386  helicase activity
GO:0016787  hydrolase activity
GO:0016817  hydrolase activity, acting on acid anhydrides
GO:0016818  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0051536  iron-sulfur cluster binding
GO:0046872  metal ion binding
GO:0003676  nucleic acid binding
GO:0000166  nucleotide binding
GO:0008022  protein C-terminus binding
GO:0004672  protein kinase activity
GO:0047485  protein N-terminus binding
GO:0008353  RNA polymerase II carboxy-terminal domain kinase activity