GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus

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Synonym

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:363

cerebellum:110.50

brain stem:286

corpus callosum/glia:-

pineal gland:2320.20

peripheral nerve:515.90

spine:141.90

retina:675

eye:524.30

artery/aorta:253.20

vein:-

lymphnode:32.40

peripheral blood:402.60

spleen:52.70

thymus:148.20

bone marrow:910.30

adipose:-

bone:551.10

skin:316.70

GeneChip

cerebrum:13.35

cerebellum:13.49

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:14.05

spine:13.81

retina:10.98

eye:11.39

artery/aorta:-

vein:13.75

lymphnode:12.63

peripheral blood:-

spleen:12.64

thymus:-

bone marrow:12.51

adipose:13.33

bone:12.46

skin:12.07

CAGE

cerebrum:5.14

cerebellum:-

brain stem:6.64

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:7.02

retina:-

eye:-

artery/aorta:7.35

vein:-

lymphnode:4.68

peripheral blood:-

spleen:4.98

thymus:4.61

bone marrow:-

adipose:-

bone:4.83

skin:4.83

RNA-seq

cerebrum:502.34

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:785.20

placenta:276.10

prostate:401.50

ovary:183.90

testis:44.30

heart:613.90

muscle:816.70

esophagus:-

stomach:752.80

intestine:147.90

colon:511

liver/hepato:244.40

lung:552.30

bladder:-

kidney:403

pituitary:1020.50

thyroid/parathyroid:337.40

adrenal gland:848.90

pancreas:609.80

breast:594.20

salivary:809.90

GeneChip

uterus:12.94

placenta:12.79

prostate:13.13

ovary:13.21

testis:10.49

heart:13.30

muscle:13.46

esophagus:-

stomach:12.65

intestine:12.43

colon:-

liver/hepato:12.43

lung:13.23

bladder:12.95

kidney:12.69

pituitary:14.52

thyroid/parathyroid:-

adrenal gland:14.12

pancreas:12.68

breast:13.03

salivary:12.96

CAGE

uterus:5.53

placenta:5.92

prostate:6.00

ovary:5.67

testis:4.41

heart:-

muscle:-

esophagus:-

stomach:5.22

intestine:4.44

colon:4.53

liver/hepato:4.95

lung:5.10

bladder:5.60

kidney:-

pituitary:8.44

thyroid/parathyroid:-

adrenal gland:6.76

pancreas:5.84

breast:5.16

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:273.63

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:79.10

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_010309
Gene ID	14683
Unigene ID	Mm.125770
Probe set ID	1450186_s_at [Mouse430_2]
Ensembl ID	ENSMUSG00000027523

Orthologous Gene

Human[74]	NM_000516, NM_001077488, NM_001077489, NM_001077490, NM_016592, NM_080425, NM_080426
Rat[74]	NM_000516, NM_001077488, NM_001077489, NM_001077490, NM_016592, NM_080425, NM_080426

Chromosomal Region

2H4 [174,109,821 - 174,172,245]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000367	G-protein alpha subunit, group S
IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit

Gene Ontology (GO ID)

Biological Process

GO:0007191	activation of adenylate cyclase activity by dopamine receptor signaling pathway
GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway
GO:0051216	cartilage development
GO:0006306	DNA methylation
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0035116	embryonic hindlimb morphogenesis
GO:0001958	endochondral ossification
GO:0006112	energy reserve metabolic process
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0006184	GTP catabolic process
GO:0035264	multicellular organism growth
GO:0045669	positive regulation of osteoblast differentiation
GO:0045672	positive regulation of osteoclast differentiation
GO:0040032	post-embryonic body morphogenesis
GO:0009791	post-embryonic development
GO:0042493	response to drug
GO:0007606	sensory perception of chemical stimulus
GO:0007165	signal transduction
GO:0001501	skeletal system development
GO:0043588	skin development
GO:0001894	tissue homeostasis

Cellular Component

GO:0042995	cell projection
GO:0031410	cytoplasmic vesicle
GO:0030425	dendrite
GO:0005576	extracellular region
GO:0031234	extrinsic to internal side of plasma membrane
GO:0005834	heterotrimeric G-protein complex
GO:0016020	membrane
GO:0005886	plasma membrane

Molecular Function

GO:0031683	G-protein beta/gamma-subunit binding
GO:0005525	GTP binding
GO:0003924	GTPase activity
GO:0019001	guanyl nucleotide binding
GO:0035255	ionotropic glutamate receptor binding
GO:0046872	metal ion binding
GO:0031852	mu-type opioid receptor binding
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0004871	signal transducer activity

GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function