histone deacetylase 5

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Synonym

HD5, mKIAA0600, histone deacetylase 5, Histone deacetylase 5, mHDA1, AI426555, Histone deacetylase mHDA1, Hdac5, Hdac4

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:237.90

cerebellum:73.70

brain stem:127.10

corpus callosum/glia:-

pineal gland:257.80

peripheral nerve:152.90

spine:189.10

retina:128.60

eye:190

artery/aorta:168.80

vein:-

lymphnode:216

peripheral blood:43.10

spleen:144.80

thymus:29.60

bone marrow:25.60

adipose:-

bone:263

skin:174.20

GeneChip

cerebrum:9.38

cerebellum:9.21

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:7.81

spine:9.40

retina:9.23

eye:7.83

artery/aorta:-

vein:7.87

lymphnode:7.93

peripheral blood:-

spleen:8.11

thymus:-

bone marrow:8.16

adipose:8.32

bone:7.78

skin:8.75

CAGE

cerebrum:4.31

cerebellum:-

brain stem:4.71

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:4.56

retina:-

eye:-

artery/aorta:3.87

vein:-

lymphnode:3.24

peripheral blood:-

spleen:3.13

thymus:3.14

bone marrow:-

adipose:-

bone:3.54

skin:4.30

RNA-seq

cerebrum:25.44

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:43.60

placenta:138.10

prostate:30.90

ovary:11.50

testis:36.90

heart:446.40

muscle:106.50

esophagus:-

stomach:32.70

intestine:-

colon:35.20

liver/hepato:63.40

lung:80.30

bladder:198.50

kidney:56.40

pituitary:77.50

thyroid/parathyroid:112.50

adrenal gland:424.40

pancreas:103.20

breast:114.30

salivary:270

GeneChip

uterus:8.87

placenta:7.64

prostate:8.04

ovary:8.54

testis:8.77

heart:8.49

muscle:8.33

esophagus:-

stomach:7.93

intestine:7.57

colon:-

liver/hepato:8.10

lung:8.61

bladder:8.24

kidney:8.04

pituitary:8.89

thyroid/parathyroid:-

adrenal gland:8.31

pancreas:8.08

breast:8.04

salivary:8.12

CAGE

uterus:3.69

placenta:2.92

prostate:3.29

ovary:3.65

testis:2.89

heart:-

muscle:-

esophagus:-

stomach:3.13

intestine:2.69

colon:3.21

liver/hepato:3.09

lung:3.91

bladder:3.87

kidney:-

pituitary:3.95

thyroid/parathyroid:-

adrenal gland:3.79

pancreas:3.80

breast:3.23

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:7.35

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:5.20

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_001077696
Gene ID	15184
Unigene ID	Mm.22665
Probe set ID	1415743_at [Mouse430_2]
Ensembl ID	ENSMUSG00000008855

Orthologous Gene

Human[2]	NM_001015053, NM_005474
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

IPR017320	Histone deacetylase class II, eukaryotic
IPR000286	Histone deacetylase superfamily

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0042113	B cell activation
GO:0030183	B cell differentiation
GO:0071498	cellular response to fluid shear stress
GO:0016568	chromatin modification
GO:0007507	heart development
GO:0016575	histone deacetylation
GO:0006954	inflammatory response
GO:0033555	multicellular organismal response to stress
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
GO:0010832	negative regulation of myotube differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045843	negative regulation of striated muscle tissue development
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0007399	nervous system development
GO:0002076	osteoblast development
GO:0051091	positive regulation of transcription factor activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0010830	regulation of myotube differentiation
GO:0043393	regulation of protein binding
GO:0048742	regulation of skeletal muscle fiber development
GO:0051153	regulation of striated muscle cell differentiation
GO:0006355	regulation of transcription, DNA-dependent
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0006351	transcription, DNA-dependent

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005794	Golgi apparatus
GO:0000118	histone deacetylase complex
GO:0016604	nuclear body
GO:0005634	nucleus
GO:0043234	protein complex

Molecular Function

GO:0044212	DNA regulatory region binding
GO:0004407	histone deacetylase activity
GO:0031078	histone deacetylase activity (H3-K14 specific)
GO:0034739	histone deacetylase activity (H3-K16 specific)
GO:0032129	histone deacetylase activity (H3-K9 specific)
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0005080	protein kinase C binding
GO:0003714	transcription corepressor activity
GO:0008134	transcription factor binding
GO:0070491	transcription repressor binding

histone deacetylase 5

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function