homeodomain interacting protein kinase 2

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Synonym

Stank, Homeodomain-interacting protein kinase 2, Nuclear body-associated kinase 1, 1110014O20Rik, Nbak1, Hipk2, B230339E18Rik, homeodomain interacting protein kinase 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:34.70 cerebellum:36.80 brain stem:158.90 corpus callosum/glia:- pineal gland:- peripheral nerve:95.50 spine:47.30 retina:128.60 eye:15.20 artery/aorta:84.40 vein:- lymphnode:54 peripheral blood:- spleen:105.30 thymus:19.80 bone marrow:38.50 adipose:1276.30 bone:25 skin:15.80
GeneChip cerebrum:8.04 cerebellum:8.74 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.25 spine:9.24 retina:7.68 eye:7.71 artery/aorta:- vein:7.17 lymphnode:7.76 peripheral blood:- spleen:7.69 thymus:- bone marrow:8.80 adipose:8.79 bone:7.76 skin:7.81
CAGE cerebrum:4.33 cerebellum:- brain stem:4.88 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:5.13 retina:- eye:- artery/aorta:4.72 vein:- lymphnode:4.13 peripheral blood:- spleen:4.54 thymus:2.82 bone marrow:- adipose:- bone:4.51 skin:4.93
RNA-seq cerebrum:2.63 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:13.80 prostate:30.90 ovary:252.80 testis:29.60 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:18.10        lung:10    bladder:- kidney:40.30 pituitary:155 thyroid/parathyroid:- adrenal gland:424.40 pancreas:37.50 breast:16.30 salivary:54
GeneChip uterus:7.06 placenta:7.32 prostate:8.06 ovary:8.08 testis:6.87 heart:9.23 muscle:9.84 esophagus:- stomach:8.59 intestine:8.32 colon:- liver/hepato:8.09 lung:8.55 bladder:7.83 kidney:8.91 pituitary:8.50 thyroid/parathyroid:- adrenal gland:9.29 pancreas:8.23 breast:8.12 salivary:8.70
CAGE uterus:3.13 placenta:3.38 prostate:3.63 ovary:4.33 testis:4.01 heart:- muscle:- esophagus:- stomach:3.76 intestine:4.69 colon:4.57     liver/hepato:4.23    lung:4.55 bladder:4.00 kidney:- pituitary:4.22 thyroid/parathyroid:- adrenal gland:4.61 pancreas:5.04 breast:3.87 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.62 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.82        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010433
Gene ID 15258
Unigene ID Mm.23790
Probe set ID 1424863_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000061436

Orthologous Gene

Human[6]  NM_001113239, NM_022740
Rat[1]  NM_001108622, NM_022740

Chromosomal Region

6B1  [38,644,389  -  38,826,189]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8889548
9748262
10349636
10535925
10919273
11042159
11076861
11078605
11120354
11217851
11267674
11544199
11593421
11780126
11798164
12466851
12477932
12529400
12851404
14567915
14681479
14990717
15082531
15492043
15526030
16141072
16141073
16407227
16537918
16729035
16738336
16917507
16919269
16940173
17064687
17159989
17349959
17666529
17967808
18093972
18311719
18378044
18483253
18772243
18799693
19820693
20231426
20307497
20360400
20573984
20579985
20637728
20808911
20940704
21267068
21362171
21785465
21957238
22406746
22658722
23565059
23782693
23871434
24145406
24785298

Gene Ontology  (GO ID)

Biological Process

GO:0008344  adult locomotory behavior
GO:0007628  adult walking behavior
GO:0009952  anterior/posterior pattern formation
GO:0006915  apoptosis
GO:0042771  DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0006978  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0048596  embryonic camera-type eye morphogenesis
GO:0060059  embryonic retina morphogenesis in camera-type eye
GO:0060235  lens induction in camera-type eye
GO:0030514  negative regulation of BMP signaling pathway
GO:0043524  negative regulation of neuron apoptosis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0030182  neuron differentiation
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0016310  phosphorylation
GO:0045766  positive regulation of angiogenesis
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0046330  positive regulation of JNK cascade
GO:0032092  positive regulation of protein binding
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0006468  protein amino acid phosphorylation
GO:0006355  regulation of transcription, DNA-dependent
GO:0006974  response to DNA damage stimulus
GO:0010842  retina layer formation
GO:0060395  SMAD protein signal transduction
GO:0007224  smoothened signaling pathway
GO:0006351  transcription, DNA-dependent
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0050882  voluntary musculoskeletal movement

Cellular Component

GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0016604  nuclear body
GO:0031965  nuclear membrane
GO:0005634  nucleus
GO:0016605  PML body

Molecular Function

GO:0005524  ATP binding
GO:0003677  DNA binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0003714  transcription corepressor activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0046790  virion binding