hyaluronoglucosaminidase 2

 jump to detail

Synonym

hyaluronoglucosaminidase 2, Hyal2, Hyaluronoglucosaminidase-2, AU020858, AW555733, LUCA-2, AI256841, Hyal-2, Hyaluronidase-2 precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:7.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.56 cerebellum:6.65 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.78 spine:6.82 retina:6.77 eye:7.10 artery/aorta:- vein:7.69 lymphnode:8.12 peripheral blood:- spleen:7.23 thymus:- bone marrow:7.01 adipose:7.78 bone:6.86 skin:7.51
CAGE cerebrum:2.11 cerebellum:- brain stem:2.23 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.35 retina:- eye:- artery/aorta:3.12 vein:- lymphnode:2.23 peripheral blood:- spleen:2.59 thymus:2.29 bone marrow:- adipose:- bone:3.02 skin:3.30
RNA-seq cerebrum:2.53 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:35.20     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:7.69 placenta:7.69 prostate:7.31 ovary:7.92 testis:6.36 heart:7.60 muscle:7.39 esophagus:- stomach:7.82 intestine:8.15 colon:- liver/hepato:8.63 lung:8.97 bladder:7.53 kidney:8.29 pituitary:7.28 thyroid/parathyroid:- adrenal gland:7.09 pancreas:7.41 breast:7.39 salivary:7.30
CAGE uterus:3.24 placenta:3.21 prostate:2.79 ovary:3.42 testis:1.18 heart:- muscle:- esophagus:- stomach:3.21 intestine:3.21 colon:3.85     liver/hepato:3.72    lung:3.15 bladder:3.47 kidney:- pituitary:2.87 thyroid/parathyroid:- adrenal gland:2.68 pancreas:2.45 breast:2.87 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.41 esophagus:- stomach:- intestine:- colon:-     liver/hepato:6.77        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010489
Gene ID 15587
Unigene ID Mm.4834
Probe set ID 1448679_at  [Mouse430_2]
Ensembl ID ENSMUSG00000010047

Orthologous Gene

Human[2]  NM_003773, NM_033158
Rat[2]  NM_172040, NM_033158

Chromosomal Region

-

Gene Family (Interpro ID)

IPR018155  Hyaluronidase

Link to Pubmed  (Pubmed ID)

7671812
9790770
10349636
10725249
10922068
11042159
11076861
11217851
11296287
11731268
11929860
11960552
12466851
12477932
12584308
14610273
14681479
16141072
16141073
16191204
18267097
18653706
18772348
18799693
19366691
19443707
21084671
21267068
21740893
23172227

Gene Ontology  (GO ID)

Biological Process

GO:0005975  carbohydrate metabolic process
GO:0071347  cellular response to interleukin-1
GO:0071493  cellular response to UV-B
GO:0051607  defense response to virus
GO:0046718  entry of virus into host cell
GO:0006027  glycosaminoglycan catabolic process
GO:0002244  hemopoietic progenitor cell differentiation
GO:0030214  hyaluronan catabolic process
GO:0008152  metabolic process
GO:0042117  monocyte activation
GO:0010259  multicellular organismal aging
GO:0060586  multicellular organismal iron ion homeostasis
GO:0030308  negative regulation of cell growth
GO:0010764  negative regulation of fibroblast migration
GO:0043407  negative regulation of MAP kinase activity
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0050729  positive regulation of inflammatory response
GO:0042307  positive regulation of protein import into nucleus
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0000302  response to reactive oxygen species
GO:0009615  response to virus
GO:0048705  skeletal system morphogenesis
GO:0019087  transformation of host cell by virus
GO:0019064  viral envelope fusion with host membrane

Cellular Component

GO:0031362  anchored to external side of plasma membrane
GO:0031225  anchored to membrane
GO:0046658  anchored to plasma membrane
GO:0016324  apical plasma membrane
GO:0009986  cell surface
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0044444  cytoplasmic part
GO:0031410  cytoplasmic vesicle
GO:0005829  cytosol
GO:0030139  endocytic vesicle
GO:0000139  Golgi membrane
GO:0005764  lysosome
GO:0016020  membrane
GO:0045121  membrane raft
GO:0005902  microvillus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0003824  catalytic activity
GO:0019899  enzyme binding
GO:0005540  hyaluronic acid binding
GO:0033906  hyaluronoglucuronidase activity
GO:0004415  hyalurononglucosaminidase activity
GO:0016787  hydrolase activity
GO:0016798  hydrolase activity, acting on glycosyl bonds
GO:0030294  receptor signaling protein tyrosine kinase inhibitor activity
GO:0030971  receptor tyrosine kinase binding
GO:0050431  transforming growth factor beta binding
GO:0001618  viral receptor activity