CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

Synonym

Ii, HLA-DR-GAMMA, DHLAG, Ia-GAMMA, HLADG, Cd74, Ia antigen-associated invariant chain, CLIP, CD74 antigen, MHC class II-associated invariant chain

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:5.20

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:257.80

peripheral nerve:-

spine:-

retina:-

eye:38

artery/aorta:-

vein:-

lymphnode:972.10

peripheral blood:14.40

spleen:184.30

thymus:29.60

bone marrow:-

adipose:-

bone:50.10

skin:15.80

GeneChip

cerebrum:6.77

cerebellum:6.48

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:9.20

spine:7.42

retina:6.35

eye:6.86

artery/aorta:-

vein:6.73

lymphnode:14.09

peripheral blood:-

spleen:14.07

thymus:-

bone marrow:11.61

adipose:11.16

bone:11.39

skin:11.08

CAGE

cerebrum:2.83

cerebellum:-

brain stem:3.33

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:3.27

retina:-

eye:-

artery/aorta:7.01

vein:-

lymphnode:9.85

peripheral blood:-

spleen:8.15

thymus:7.80

bone marrow:-

adipose:-

bone:5.64

skin:6.73

RNA-seq

cerebrum:5.01

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:43.60

placenta:-

prostate:30.90

ovary:-

testis:-

heart:18.60

muscle:71

esophagus:-

stomach:65.50

intestine:332.80

colon:475.80

liver/hepato:63.40

lung:632.60

bladder:66.20

kidney:185.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:65.70

breast:522.40

salivary:755.90

GeneChip

uterus:11.72

placenta:7.22

prostate:10.37

ovary:11.48

testis:7.71

heart:10.49

muscle:10.33

esophagus:-

stomach:10.53

intestine:11.84

colon:-

liver/hepato:9.87

lung:13.10

bladder:11.39

kidney:10.58

pituitary:9.81

thyroid/parathyroid:-

adrenal gland:10.78

pancreas:9.66

breast:11.81

salivary:10.76

CAGE

uterus:6.05

placenta:3.42

prostate:5.45

ovary:6.20

testis:1.97

heart:-

muscle:-

esophagus:-

stomach:6.51

intestine:5.62

colon:8.55

liver/hepato:5.50

lung:7.94

bladder:6.52

kidney:-

pituitary:5.39

thyroid/parathyroid:-

adrenal gland:7.13

pancreas:6.23

breast:6.91

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:17.11

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:14.65

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_001042605
Gene ID	16149
Unigene ID	Mm.439737
Probe set ID	1425519_a_at [Mouse430_2]
Ensembl ID	ENSMUSG00000024610

Orthologous Gene

Human[3]	NM_001025158, NM_001025159, NM_004355
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0008283	cell proliferation
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0006952	defense response
GO:0006955	immune response
GO:0016064	immunoglobulin mediated immune response
GO:0006886	intracellular protein transport
GO:0043066	negative regulation of apoptosis
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0002906	negative regulation of mature B cell apoptosis
GO:0002792	negative regulation of peptide secretion
GO:0045581	negative regulation of T cell differentiation
GO:0045060	negative thymic T cell selection
GO:0002821	positive regulation of adaptive immune response
GO:0030890	positive regulation of B cell proliferation
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0048146	positive regulation of fibroblast proliferation
GO:0045089	positive regulation of innate immune response
GO:0060907	positive regulation of macrophage cytokine production
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0045582	positive regulation of T cell differentiation
GO:0002830	positive regulation of T-helper 2 type immune response
GO:0045059	positive thymic T cell selection
GO:0001516	prostaglandin biosynthetic process
GO:0006461	protein complex assembly
GO:0007165	signal transduction

Cellular Component

GO:0009986	cell surface
GO:0005783	endoplasmic reticulum
GO:0009897	external side of plasma membrane
GO:0005794	Golgi apparatus
GO:0016021	integral to membrane
GO:0005887	integral to plasma membrane
GO:0005770	late endosome
GO:0005764	lysosome
GO:0016020	membrane
GO:0042613	MHC class II protein complex
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0005773	vacuole

Molecular Function

GO:0001540	beta-amyloid binding
GO:0019955	cytokine binding
GO:0004896	cytokine receptor activity
GO:0042289	MHC class II protein binding
GO:0050998	nitric-oxide synthase binding
GO:0005515	protein binding

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function