integrin linked kinase

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Synonym

integrin linked kinase, Integrin-linked protein kinase, Ilk, AA511515, ESTM24

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:66 cerebellum:- brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:133.80 spine:141.90 retina:96.40 eye:45.60 artery/aorta:- vein:- lymphnode:32.40 peripheral blood:14.40 spleen:39.50 thymus:- bone marrow:102.60 adipose:- bone:225.40 skin:110.80
GeneChip cerebrum:9.17 cerebellum:9.52 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:10.34 spine:9.49 retina:8.37 eye:8.71 artery/aorta:- vein:10.70 lymphnode:9.91 peripheral blood:- spleen:10.08 thymus:- bone marrow:10.84 adipose:10.17 bone:10.58 skin:8.82
CAGE cerebrum:3.32 cerebellum:- brain stem:3.40 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.39 retina:- eye:- artery/aorta:4.57 vein:- lymphnode:3.78 peripheral blood:- spleen:4.12 thymus:3.46 bone marrow:- adipose:- bone:4.42 skin:3.46
RNA-seq cerebrum:12.95 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:55.20 prostate:30.90 ovary:34.50 testis:51.70 heart:111.60 muscle:35.50 esophagus:- stomach:130.90 intestine:- colon:52.90     liver/hepato:45.30        lung:100.40    bladder:198.50 kidney:40.30 pituitary:180.80 thyroid/parathyroid:- adrenal gland:- pancreas:37.50 breast:117.50 salivary:54
GeneChip uterus:11.38 placenta:10.54 prostate:10.01 ovary:10.98 testis:8.38 heart:9.98 muscle:9.65 esophagus:- stomach:9.76 intestine:9.56 colon:- liver/hepato:9.48 lung:10.83 bladder:11.22 kidney:9.77 pituitary:10.23 thyroid/parathyroid:- adrenal gland:9.57 pancreas:8.93 breast:9.70 salivary:8.97
CAGE uterus:4.71 placenta:4.41 prostate:3.95 ovary:4.39 testis:2.82 heart:- muscle:- esophagus:- stomach:4.37 intestine:3.42 colon:3.50     liver/hepato:3.55    lung:4.36 bladder:4.82 kidney:- pituitary:3.74 thyroid/parathyroid:- adrenal gland:3.89 pancreas:3.45 breast:3.91 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:8.16 esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.50        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010562
Gene ID 16202
Unigene ID Mm.274846
Probe set ID 1449942_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000030890

Orthologous Gene

Human[6]  NM_001014794, NM_001014795, NM_004517
Rat[1]  NM_133409, NM_001014795, NM_004517

Chromosomal Region

7E3  [112,885,106  -  112,891,439]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

9366252
10349636
10574708
11042159
11076861
11217851
11304546
11704830
12432066
12466851
12477932
12547824
12670870
12671688
12686550
12714590
12835312
12925691
14522949
14581460
14610273
14699151
15021910
15226823
15340074
15489334
15565145
15713628
15782199
15802621
15831470
15872073
15975904
16049178
16115889
16141072
16141073
16314534
16317048
16421303
16474180
16611717
16799642
16837631
16840719
16914328
16951252
16962068
17322895
17385211
17485490
17526737
17588951
17989364
18037995
18055553
18082680
18234842
18269918
18325335
18332223
18450752
18503049
18505933
18535176
18772455
18773488
18846549
19211680
19258742
19349584
19409087
19435803
19439446
19460706
19541809
19575460
19652092
19793892
19797768
19798050
19829382
19920070
20135642
20163538
20164118
20164304
20178627
20305688
20505657
20564195
20576809
20675382
20823064
20857141
20951348
20980390
21060779
21150927
21220513
21267068
21351095
21401944
21524996
21593206
21677750
21778429
21806815
21913214
21983115
22083510
22160594
22194624
22491404
22570869
22574216
22677169
22677557
22767228
22971619
23236519
23263281
23404105
23580202
23612611
23658024
23715557
23739974
23744273
23877428
24095779
24131868
24260102
24319095
24383472
24472646
24598164
24719101

Gene Ontology  (GO ID)

Biological Process

GO:0001658  branching involved in ureteric bud morphogenesis
GO:0007569  cell aging
GO:0007050  cell cycle arrest
GO:0030030  cell projection organization
GO:0045197  establishment or maintenance of epithelial cell apical/basal polarity
GO:0043206  fibril organization
GO:0007229  integrin-mediated signaling pathway
GO:0032288  myelin assembly
GO:0022011  myelination in the peripheral nervous system
GO:0043066  negative regulation of apoptosis
GO:0010667  negative regulation of cardiac muscle cell apoptosis
GO:0043524  negative regulation of neuron apoptosis
GO:0006469  negative regulation of protein kinase activity
GO:0014912  negative regulation of smooth muscle cell migration
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0021675  nerve development
GO:0048812  neuron projection morphogenesis
GO:0018105  peptidyl-serine phosphorylation
GO:0016310  phosphorylation
GO:0045773  positive regulation of axon extension
GO:0050772  positive regulation of axonogenesis
GO:0030513  positive regulation of BMP signaling pathway
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0001954  positive regulation of cell-matrix adhesion
GO:0050775  positive regulation of dendrite morphogenesis
GO:0043406  positive regulation of MAP kinase activity
GO:0043410  positive regulation of MAPKKK cascade
GO:0045663  positive regulation of myoblast differentiation
GO:0045669  positive regulation of osteoblast differentiation
GO:0042327  positive regulation of phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006468  protein amino acid phosphorylation
GO:0051291  protein heterooligomerization
GO:0043491  protein kinase B signaling cascade
GO:0032956  regulation of actin cytoskeleton organization
GO:0001558  regulation of cell growth
GO:0009966  regulation of signal transduction
GO:0014044  Schwann cell development
GO:0034446  substrate adhesion-dependent cell spreading

Cellular Component

GO:0030424  axon
GO:0030054  cell junction
GO:0042995  cell projection
GO:0043025  cell soma
GO:0005911  cell-cell junction
GO:0043034  costamere
GO:0005737  cytoplasm
GO:0043198  dendritic shaft
GO:0005925  focal adhesion
GO:0030027  lamellipodium
GO:0016020  membrane
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0001725  stress fiber
GO:0043195  terminal button

Molecular Function

GO:0005524  ATP binding
GO:0005178  integrin binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0004674  protein serine/threonine kinase activity
GO:0017124  SH3 domain binding
GO:0004871  signal transducer activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups