luteinizing hormone/choriogonadotropin receptor

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Synonym

luteinizing hormone/choriogonadotropin receptor, Luteinizing hormone receptor, LH/CG-R, Lhr, LSH-R, Gpcr19-rs1, LH-R, Lhcgr

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.70 cerebellum:18.40 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:57.30 spine:- retina:- eye:15.20 artery/aorta:- vein:- lymphnode:- peripheral blood:172.50 spleen:- thymus:29.60 bone marrow:- adipose:- bone:- skin:23.80
GeneChip cerebrum:3.54 cerebellum:3.38 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:3.67 spine:3.54 retina:3.65 eye:3.67 artery/aorta:- vein:3.71 lymphnode:3.60 peripheral blood:- spleen:3.42 thymus:- bone marrow:3.49 adipose:3.72 bone:3.56 skin:3.58
CAGE cerebrum:0.48 cerebellum:- brain stem:0.66 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.75 retina:- eye:- artery/aorta:0.36 vein:- lymphnode:0 peripheral blood:- spleen:0.16 thymus:0 bone marrow:- adipose:- bone:0 skin:0.15
RNA-seq cerebrum:0.41 cerebellum:0.41 brain stem:0.41 corpus callosum/glia:0.41 pineal gland:0.41 peripheral nerve:0.41 spine:0.41 retina:0.41 eye:0.41 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:87.20 placenta:- prostate:- ovary:- testis:7.40 heart:- muscle:- esophagus:- stomach:32.70 intestine:- colon:-     liver/hepato:-        lung:50.20    bladder:- kidney:32.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:9.40 breast:19.60 salivary:-
GeneChip uterus:3.50 placenta:3.61 prostate:3.45 ovary:9.42 testis:4.15 heart:3.69 muscle:3.42 esophagus:- stomach:3.54 intestine:3.57 colon:- liver/hepato:3.85 lung:3.40 bladder:3.60 kidney:3.71 pituitary:3.53 thyroid/parathyroid:- adrenal gland:3.39 pancreas:3.57 breast:3.65 salivary:3.86
CAGE uterus:0.74 placenta:0 prostate:0.37 ovary:5.11 testis:2.25 heart:- muscle:- esophagus:- stomach:0 intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0.18 kidney:- pituitary:0.52 thyroid/parathyroid:- adrenal gland:0 pancreas:0 breast:0 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_013582
Gene ID 16867
Unigene ID Mm.164436
Probe set ID 1450192_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024107

Orthologous Gene

Human[1]  NM_000233
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000276  7TM GPCR, rhodopsin-like
IPR002131  Glycoprotein hormone receptor
IPR017452  GPCR, rhodopsin-like superfamily
IPR002273  Lutropin-choriogonadotropic hormone receptor

Link to Pubmed  (Pubmed ID)

1311310
1459341
2502842
7556872
7672443
7720577
7736780
7892197
8252616
8288218
8559204
8575305
8751373
8807640
8833235
8887325
9282997
9492048
9823302
10349636
10493819
10537163
11042159
11076861
11145748
11145749
11217851
11226072
11312274
11943741
11988311
11988312
12032072
12466851
12604639
12865338
12933687
14585929
14645113
14726449
15232063
15253923
15256532
15256533
15514086
15814897
15821112
15836959
15941853
15951841
15970507
16024815
16034175
16141072
16141073
16293639
16361283
16412416
16602821
16730882
16919269
17065221
17130239
17350160
17376589
17603480
17640960
17727840
19013498
20080658
20093417
20142765
20154177
20164437
20798391
20805495
21267068
21389345
22875961
23136395
23261984
23464498
23471219
23861372

Gene Ontology  (GO ID)

Biological Process

GO:0007190  activation of adenylate cyclase activity
GO:0007200  activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0050482  arachidonic acid secretion
GO:0071371  cellular response to gonadotropin stimulus
GO:0046544  development of secondary male sexual characteristics
GO:0008585  female gonad development
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007188  G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0009755  hormone-mediated signaling pathway
GO:0042700  luteinizing hormone signaling pathway
GO:0008584  male gonad development
GO:0001541  ovarian follicle development
GO:0022602  ovulation cycle process
GO:0010524  positive regulation of calcium ion transport into cytosol
GO:0050850  positive regulation of calcium-mediated signaling
GO:0043950  positive regulation of cAMP-mediated signaling
GO:0046886  positive regulation of hormone biosynthetic process
GO:0032962  positive regulation of inositol trisphosphate biosynthetic process
GO:0051281  positive regulation of release of sequestered calcium ion into cytosol
GO:0006622  protein targeting to lysosome
GO:0090030  regulation of steroid hormone biosynthetic process
GO:0007165  signal transduction
GO:0007283  spermatogenesis
GO:0060065  uterus development

Cellular Component

GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0005768  endosome
GO:0005615  extracellular space
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0031233  intrinsic to external side of plasma membrane
GO:0005764  lysosome
GO:0016020  membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0043235  receptor complex

Molecular Function

GO:0051117  ATPase binding
GO:0004930  G-protein coupled receptor activity
GO:0042802  identical protein binding
GO:0004964  lutropin-choriogonadotropic hormone receptor activity
GO:0017046  peptide hormone binding
GO:0008528  peptide receptor activity, G-protein coupled
GO:0042803  protein homodimerization activity
GO:0016500  protein-hormone receptor activity
GO:0004871  signal transducer activity