MAD homolog 6 (Drosophila)

Synonym

Msmad6, Madh6, Madh7, Mothers against decapentaplegic homolog 6, MAD homolog 6 (Drosophila), Mad homolog 7, Mothers against DPP homolog 6, Smad 6, SMAD 6, Smad6

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:1.70

cerebellum:18.40

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:32.10

eye:7.60

artery/aorta:-

vein:-

lymphnode:54

peripheral blood:-

spleen:-

thymus:9.90

bone marrow:-

adipose:425.40

bone:-

skin:15.80

GeneChip

cerebrum:4.87

cerebellum:4.35

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:4.85

spine:4.99

retina:4.89

eye:6.80

artery/aorta:-

vein:8.11

lymphnode:5.49

peripheral blood:-

spleen:5.05

thymus:-

bone marrow:5.09

adipose:7.16

bone:6.17

skin:5.36

CAGE

cerebrum:0.80

cerebellum:-

brain stem:0.92

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:0.91

retina:-

eye:-

artery/aorta:2.69

vein:-

lymphnode:0.57

peripheral blood:-

spleen:0.16

thymus:0.49

bone marrow:-

adipose:-

bone:0.63

skin:2.05

RNA-seq

cerebrum:1.22

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:30.90

ovary:-

testis:14.80

heart:-

muscle:-

esophagus:-

stomach:32.70

intestine:-

colon:52.90

liver/hepato:18.10

lung:30.10

bladder:-

kidney:8.10

pituitary:12.90

thyroid/parathyroid:-

adrenal gland:-

pancreas:28.10

breast:42.40

salivary:-

GeneChip

uterus:6.67

placenta:8.02

prostate:5.73

ovary:6.68

testis:8.71

heart:8.05

muscle:6.73

esophagus:-

stomach:8.14

intestine:7.75

colon:-

liver/hepato:6.66

lung:11.23

bladder:7.85

kidney:7.05

pituitary:5.74

thyroid/parathyroid:-

adrenal gland:6.32

pancreas:6.86

breast:6.18

salivary:5.58

CAGE

uterus:2.34

placenta:2.60

prostate:2.72

ovary:1.66

testis:3.75

heart:-

muscle:-

esophagus:-

stomach:2.79

intestine:2.13

colon:2.66

liver/hepato:2.02

lung:4.27

bladder:2.47

kidney:-

pituitary:1.56

thyroid/parathyroid:-

adrenal gland:1.64

pancreas:2.45

breast:0.93

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.21

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:1.82

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_008542
Gene ID	17130
Unigene ID	Mm.325757
Probe set ID	1422771_at [Mouse430_2]
Ensembl ID	ENSMUSG00000036867

Orthologous Gene

Human[3]	NM_001142861, NM_005585
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

IPR003619	MAD homology 1, Dwarfin-type
IPR013019	MAD homology, MH1
IPR001132	SMAD domain, Dwarfin-type
IPR017855	SMAD domain-like
IPR008984	SMAD/FHA domain

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0060948	cardiac vascular smooth muscle cell development
GO:0031589	cell-substrate adhesion
GO:0060977	coronary vasculature morphogenesis
GO:0006955	immune response
GO:0043066	negative regulation of apoptosis
GO:0030514	negative regulation of BMP signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0010991	negative regulation of SMAD protein complex assembly
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0045908	negative regulation of vasodilation
GO:0045907	positive regulation of vasoconstriction
GO:0006355	regulation of transcription, DNA-dependent
GO:0006351	transcription, DNA-dependent
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007352	zygotic determination of dorsal/ventral axis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005667	transcription factor complex

Molecular Function

GO:0003682	chromatin binding
GO:0070410	co-SMAD binding
GO:0003677	DNA binding
GO:0044212	DNA regulatory region binding
GO:0070411	I-SMAD binding
GO:0046872	metal ion binding
GO:0005515	protein binding
GO:0070412	R-SMAD binding
GO:0003700	transcription factor activity
GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0070698	type I activin receptor binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0031625	ubiquitin protein ligase binding

MAD homolog 6 (Drosophila)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function