NK2 transcription factor related, locus 5 (Drosophila)

Synonym

Homeobox protein CSX, Homeobox protein NK-2 homolog E, Nkx2.5, Csx, Cardiac-specific homeobox, Nkx2-5, Nkx2e, Nkx-2.5, Homeobox protein Nkx-2.5

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:5.90

cerebellum:6.06

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:5.78

spine:6.07

retina:6.38

eye:6.75

artery/aorta:-

vein:5.88

lymphnode:5.62

peripheral blood:-

spleen:6.88

thymus:-

bone marrow:5.99

adipose:6.03

bone:5.79

skin:5.77

CAGE

cerebrum:0

cerebellum:-

brain stem:0

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:0

retina:-

eye:-

artery/aorta:0

vein:-

lymphnode:0

peripheral blood:-

spleen:1.94

thymus:0

bone marrow:-

adipose:-

bone:0

skin:0

RNA-seq

nodata

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:130.20

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:10

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:65.70

breast:3.30

salivary:-

GeneChip

uterus:5.60

placenta:6.18

prostate:5.94

ovary:5.51

testis:6.27

heart:9.67

muscle:5.94

esophagus:-

stomach:6.05

intestine:5.93

colon:-

liver/hepato:6.07

lung:5.86

bladder:5.73

kidney:6.09

pituitary:6.06

thyroid/parathyroid:-

adrenal gland:5.57

pancreas:7

breast:5.85

salivary:5.94

CAGE

uterus:0

placenta:0

prostate:0

ovary:0

testis:0

heart:-

muscle:-

esophagus:-

stomach:0

intestine:0

colon:0

liver/hepato:0

lung:0.31

bladder:0

kidney:-

pituitary:0

thyroid/parathyroid:-

adrenal gland:0

pancreas:0

breast:0

salivary:-

RNA-seq

nodata

IDs

Refseq ID	NM_008700
Gene ID	18091
Unigene ID	Mm.41974
Probe set ID	1449566_at [Mouse430_2]
Ensembl ID	ENSMUSG00000015579

Orthologous Gene

Human[3]	NM_001166175, NM_001166176, NM_004387
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

IPR001356	Homeobox
IPR009057	Homeodomain-like
IPR012287	Homeodomain-related

Gene Ontology (GO ID)

Biological Process

GO:0007512	adult heart development
GO:0003278	apoptosis involved in heart morphogenesis
GO:0055014	atrial cardiac muscle cell development
GO:0060413	atrial septum morphogenesis
GO:0060928	atrioventricular node cell development
GO:0060929	atrioventricular node cell fate commitment
GO:0003162	atrioventricular node development
GO:0030509	BMP signaling pathway
GO:0003166	bundle of His development
GO:0003161	cardiac conduction system development
GO:0055007	cardiac muscle cell differentiation
GO:0060038	cardiac muscle cell proliferation
GO:0060048	cardiac muscle contraction
GO:0048738	cardiac muscle tissue development
GO:0055008	cardiac muscle tissue morphogenesis
GO:0003168	cardiac Purkinje fiber cell differentiation
GO:0003211	cardiac ventricle formation
GO:0003208	cardiac ventricle morphogenesis
GO:0030154	cell differentiation
GO:0035050	embryonic heart tube development
GO:0060971	embryonic heart tube left/right pattern formation
GO:0007492	endoderm development
GO:0060047	heart contraction
GO:0007507	heart development
GO:0001947	heart looping
GO:0003007	heart morphogenesis
GO:0060347	heart trabecula formation
GO:0030097	hemopoiesis
GO:0007275	multicellular organismal development
GO:0043066	negative regulation of apoptosis
GO:0010667	negative regulation of cardiac muscle cell apoptosis
GO:0010832	negative regulation of myotube differentiation
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0090090	negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0003151	outflow tract morphogenesis
GO:0003148	outflow tract septum morphogenesis
GO:0060037	pharyngeal system development
GO:0051891	positive regulation of cardioblast differentiation
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0045823	positive regulation of heart contraction
GO:0045666	positive regulation of neuron differentiation
GO:0010765	positive regulation of sodium ion transport
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter
GO:0010735	positive regulation of transcription via serum response element binding
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0003342	proepicardium development
GO:0003350	pulmonary myocardium development
GO:0060043	regulation of cardiac muscle cell proliferation
GO:0055117	regulation of cardiac muscle contraction
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-dependent
GO:0003221	right ventricular cardiac muscle tissue morphogenesis
GO:0045214	sarcomere organization
GO:0003285	septum secundum development
GO:0048536	spleen development
GO:0030878	thyroid gland development
GO:0043586	tongue development
GO:0001570	vasculogenesis
GO:0055015	ventricular cardiac muscle cell development
GO:0055005	ventricular cardiac myofibril development
GO:0060412	ventricular septum morphogenesis
GO:0003222	ventricular trabecular myocardium morphogenesis
GO:0060070	Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005737	cytoplasm
GO:0005634	nucleus
GO:0005667	transcription factor complex

Molecular Function

GO:0003682	chromatin binding
GO:0003677	DNA binding
GO:0044212	DNA regulatory region binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0042803	protein homodimerization activity
GO:0003705	RNA polymerase II transcription factor activity, enhancer binding
GO:0043565	sequence-specific DNA binding
GO:0010736	serum response element binding
GO:0003700	transcription factor activity
GO:0008134	transcription factor binding

NK2 transcription factor related, locus 5 (Drosophila)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function