platelet-activating factor acetylhydrolase, isoform 1b, subunit 1

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Synonym

Lis-1, MGC25297, PAFAH alpha, Mdsh, MMS10-U, Lissencephaly-1 protein, Ms10u, lissencephaly-1 protein, PAF-AH 45 kDa subunit, PAF-AH alpha, LIS-1, Lis1, Pafah1b1, PAF acetylhydrolase 45 kDa subunit, Pafaha

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:270.90 cerebellum:165.80 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:210.20 spine:283.70 retina:32.10 eye:281.10 artery/aorta:84.40 vein:- lymphnode:54 peripheral blood:273.20 spleen:39.50 thymus:227.20 bone marrow:115.40 adipose:212.70 bone:137.80 skin:190
GeneChip cerebrum:10.02 cerebellum:10.21 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:11.48 spine:10.57 retina:9.07 eye:9.02 artery/aorta:- vein:9.27 lymphnode:8.54 peripheral blood:- spleen:8.73 thymus:- bone marrow:8.96 adipose:8.55 bone:8.78 skin:9.13
CAGE cerebrum:5.10 cerebellum:- brain stem:5.39 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:5.49 retina:- eye:- artery/aorta:4.42 vein:- lymphnode:4.11 peripheral blood:- spleen:4.31 thymus:4.61 bone marrow:- adipose:- bone:4.46 skin:4.72
RNA-seq cerebrum:18.58 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:130.90 placenta:290 prostate:92.60 ovary:218.30 testis:155.20 heart:74.40 muscle:- esophagus:- stomach:163.60 intestine:147.90 colon:88.10     liver/hepato:-        lung:70.30    bladder:198.50 kidney:88.70 pituitary:413.40 thyroid/parathyroid:112.50 adrenal gland:- pancreas:187.60 breast:176.30 salivary:-
GeneChip uterus:8.56 placenta:8.99 prostate:8.90 ovary:8.93 testis:7.64 heart:8.78 muscle:9.25 esophagus:- stomach:8.75 intestine:9.09 colon:- liver/hepato:8.81 lung:8.84 bladder:8.78 kidney:9.20 pituitary:9.15 thyroid/parathyroid:- adrenal gland:8.75 pancreas:8.39 breast:8.69 salivary:7.82
CAGE uterus:4.39 placenta:4.61 prostate:4.56 ovary:4.39 testis:5.56 heart:- muscle:- esophagus:- stomach:4.22 intestine:4.70 colon:4.64     liver/hepato:4.17    lung:4.62 bladder:4.45 kidney:- pituitary:4.42 thyroid/parathyroid:- adrenal gland:4.58 pancreas:4.21 breast:4.25 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:7.09 esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.57        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_013625
Gene ID 18472
Unigene ID Mm.397111
Probe set ID 1417086_at  [Mouse430_2]
Ensembl ID ENSMUSG00000020745

Orthologous Gene

Human[4]  NM_000430
Rat [0]  

Chromosomal Region

11B5  [74,487,451  -  74,538,172]

Gene Family (Interpro ID)

IPR020472  G-protein beta WD-40 repeat, region
IPR006594  LisH dimerisation motif
IPR001680  WD40 repeat
IPR019782  WD40 repeat 2
IPR019781  WD40 repeat, subgroup
IPR011046  WD40 repeat-like-containing domain
IPR017986  WD40-repeat-containing domain
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

2740347
7751941
7767001
7821822
8619131
8954729
9199935
9479492
9601647
9623676
9697693
10026115
10349636
10371146
10393212
10403203
10491172
10541472
10729324
10922068
11042159
11076861
11159375
11163258
11163259
11163260
11172053
11210178
11217851
11231056
11344260
11756344
11803439
11911856
11940666
12130536
12200366
12466851
12477932
12520002
12551946
12629176
12775763
12796778
12904583
12905154
12911752
12950100
13129914
14507966
14578885
14610273
14681479
14691133
15208636
15274919
15331402
15572112
15762842
15939891
15998744
16107726
16141072
16141073
16172262
16203747
16369480
16445939
16481446
16602821
17130546
17148952
17314247
17330141
17433713
17555748
17881479
17903175
17967808
18075262
18075263
18267077
18331715
18434304
18446829
18469343
18514414
18524253
18799693
18809722
19515951
19734909
19861636
19874786
19938147
20007476
20181597
20360068
20364144
20531249
20620871
20624590
21092859
21183738
21267068
21350014
21423666
21515572
21734362
21844209
21911489
21935943
22028625
22073305
22114287
22522921
22973010
23483698
23483716
23533177
23673330
23783758
23830831
23926272
24487275

Gene Ontology  (GO ID)

Biological Process

GO:0001675  acrosome assembly
GO:0030036  actin cytoskeleton organization
GO:0008344  adult locomotory behavior
GO:0001667  ameboidal cell migration
GO:0048854  brain morphogenesis
GO:0007049  cell cycle
GO:0030154  cell differentiation
GO:0051301  cell division
GO:0016477  cell migration
GO:0021987  cerebral cortex development
GO:0021895  cerebral cortex neuron differentiation
GO:0021540  corpus callosum morphogenesis
GO:0051660  establishment of centrosome localization
GO:0000132  establishment of mitotic spindle orientation
GO:0021766  hippocampus development
GO:0021819  layer formation in the cerebral cortex
GO:0007611  learning or memory
GO:0016042  lipid catabolic process
GO:0006629  lipid metabolic process
GO:0000226  microtubule cytoskeleton organization
GO:0031023  microtubule organizing center organization
GO:0007017  microtubule-based process
GO:0007067  mitosis
GO:0007275  multicellular organismal development
GO:0046329  negative regulation of JNK cascade
GO:0010977  negative regulation of neuron projection development
GO:0007399  nervous system development
GO:0007405  neuroblast proliferation
GO:0050885  neuromuscular process controlling balance
GO:0001764  neuron migration
GO:0051081  nuclear envelope disassembly
GO:0007097  nuclear migration
GO:0045773  positive regulation of axon extension
GO:0001961  positive regulation of cytokine-mediated signaling pathway
GO:0045931  positive regulation of mitotic cell cycle
GO:0009306  protein secretion
GO:0032319  regulation of Rho GTPase activity
GO:0008090  retrograde axon cargo transport
GO:0017145  stem cell division
GO:0007268  synaptic transmission
GO:0019226  transmission of nerve impulse
GO:0006810  transport
GO:0047496  vesicle transport along microtubule

Cellular Component

GO:0000235  astral microtubule
GO:0033267  axon part
GO:0005938  cell cortex
GO:0031252  cell leading edge
GO:0043025  cell soma
GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0030426  growth cone
GO:0005871  kinesin complex
GO:0000776  kinetochore
GO:0016020  membrane
GO:0005874  microtubule
GO:0005875  microtubule associated complex
GO:0015630  microtubule cytoskeleton
GO:0031512  motile primary cilium
GO:0043005  neuron projection
GO:0031513  nonmotile primary cilium
GO:0005635  nuclear envelope
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0031982  vesicle

Molecular Function

GO:0045502  dynein binding
GO:0045505  dynein intermediate chain binding
GO:0008017  microtubule binding
GO:0051219  phosphoprotein binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0042803  protein homodimerization activity