phosphodiesterase 1A, calmodulin-dependent

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Synonym

MGC116577, AI987702, AW125737, Cam-PDE 1A, phosphodiesterase 1A, calmodulin-dependent, Pde1a, 61 kDa Cam-PDE

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:31.30 cerebellum:55.30 brain stem:158.90 corpus callosum/glia:- pineal gland:- peripheral nerve:57.30 spine:141.90 retina:32.10 eye:22.80 artery/aorta:84.40 vein:- lymphnode:- peripheral blood:- spleen:26.30 thymus:- bone marrow:- adipose:- bone:- skin:7.90
GeneChip cerebrum:8.31 cerebellum:4.55 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.21 spine:5.07 retina:4.64 eye:6.04 artery/aorta:- vein:5.90 lymphnode:4.64 peripheral blood:- spleen:4.39 thymus:- bone marrow:4.27 adipose:7.02 bone:4.59 skin:4.55
CAGE cerebrum:3.41 cerebellum:- brain stem:3.34 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.70 retina:- eye:- artery/aorta:4.08 vein:- lymphnode:2.11 peripheral blood:- spleen:0.62 thymus:0.67 bone marrow:- adipose:- bone:1.02 skin:2.13
RNA-seq cerebrum:4.19 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:11.50 testis:177.40 heart:93 muscle:- esophagus:- stomach:229.10 intestine:- colon:-     liver/hepato:-        lung:30.10    bladder:132.40 kidney:137 pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:6.50 salivary:-
GeneChip uterus:4.89 placenta:4.14 prostate:5.57 ovary:6.48 testis:9.83 heart:4.76 muscle:4.91 esophagus:- stomach:4.87 intestine:4.78 colon:- liver/hepato:4.54 lung:4.47 bladder:5.89 kidney:7.84 pituitary:5.45 thyroid/parathyroid:- adrenal gland:5.52 pancreas:5.36 breast:5.14 salivary:4.56
CAGE uterus:2.35 placenta:1.05 prostate:1.65 ovary:3.50 testis:6.02 heart:- muscle:- esophagus:- stomach:2.16 intestine:1.65 colon:1.89     liver/hepato:1.94    lung:2.01 bladder:2.73 kidney:- pituitary:3.06 thyroid/parathyroid:- adrenal gland:2.26 pancreas:1.30 breast:2.09 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.58 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.32        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001009979
Gene ID 18573
Unigene ID Mm.40678
Probe set ID 1449298_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000059173

Orthologous Gene

Human[4]  NM_001003683, NM_005019
Rat[4]  NM_001003683, NM_005019

Chromosomal Region

2C3  [79,674,610  -  79,969,632]

Gene Family (Interpro ID)

IPR003607  Metal-dependent phosphohydrolase, HD domain

Link to Pubmed  (Pubmed ID)

7568196
8889548
9003415
9032278
10349636
10922068
11042159
11076861
11217851
12135876
12466851
12477932
14681479
15901640
16141072
16141073
16512683
16514069
16959763
17307970
18335582
19797176
21267068
22012077

Gene Ontology  (GO ID)

Biological Process

GO:0006198  cAMP catabolic process
GO:0046069  cGMP catabolic process
GO:0034391  regulation of smooth muscle cell apoptosis
GO:0048660  regulation of smooth muscle cell proliferation
GO:0007165  signal transduction

Cellular Component

GO:0043025  cell soma
GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0004115  3',5'-cyclic-AMP phosphodiesterase activity
GO:0004114  3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0048101  calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
GO:0005516  calmodulin binding
GO:0004117  calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0003824  catalytic activity
GO:0030553  cGMP binding
GO:0016787  hydrolase activity
GO:0046872  metal ion binding
GO:0008081  phosphoric diester hydrolase activity