P450 (cytochrome) oxidoreductase

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Synonym

CPR, 4933424M13Rik, NADPH--cytochrome P450 reductase, P450 (cytochrome) oxidoreductase, NADH cytochrome P450 oxydoreductase, P450R, Por, CYPOR

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:8.93 cerebellum:8.48 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:8.33 spine:8.67 retina:7.84 eye:8.35 artery/aorta:- vein:8.21 lymphnode:8.67 peripheral blood:- spleen:8.39 thymus:- bone marrow:8.38 adipose:10.51 bone:8.15 skin:8.60
CAGE cerebrum:3.88 cerebellum:- brain stem:4.20 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.10 retina:- eye:- artery/aorta:5.74 vein:- lymphnode:3.77 peripheral blood:- spleen:3.67 thymus:3.63 bone marrow:- adipose:- bone:4.16 skin:4.13
RNA-seq cerebrum:20.07 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:22.20 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:10.03 placenta:9.87 prostate:9.94 ovary:9.79 testis:7.85 heart:8.79 muscle:8.25 esophagus:- stomach:10.24 intestine:9.56 colon:- liver/hepato:10.72 lung:10.81 bladder:9.74 kidney:10.94 pituitary:9.77 thyroid/parathyroid:- adrenal gland:10 pancreas:8.62 breast:9.06 salivary:8.80
CAGE uterus:4.83 placenta:4.95 prostate:4.35 ovary:4.60 testis:2.60 heart:- muscle:- esophagus:- stomach:5.09 intestine:6.23 colon:5.37     liver/hepato:6.85    lung:5.90 bladder:4.75 kidney:- pituitary:4.50 thyroid/parathyroid:- adrenal gland:5.25 pancreas:3.61 breast:4.21 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:4.31 esophagus:- stomach:- intestine:- colon:-     liver/hepato:104.10        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008898
Gene ID 18984
Unigene ID Mm.386304
Probe set ID 1416933_at  [Mouse430_2]
Ensembl ID ENSMUSG00000005514

Orthologous Gene

Human[1]  NM_000941
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001094  Flavodoxin-like
IPR008254  Flavodoxin/nitric oxide synthase
IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase

Link to Pubmed  (Pubmed ID)

1420354
2516426
3917435
6802825
7476982
7588219
8011664
8589531
9052933
9787138
10349636
10633870
10922068
11013070
11042159
11076861
11130978
11217851
11742006
11779826
12466851
12477932
12520002
12566435
12697746
12917333
12929087
14610273
14681479
15328377
15472464
15489334
15717863
15782199
15805261
15899812
16006652
16141072
16141073
16455785
16488195
16887103
17126317
17374357
17435107
17699788
17722906
18778245
18799693
19056912
19273610
19793088
20139973
20375200
20808945
20840855
21267068
21362632
21376747
21677750
21726529
21987461
22111624
22453923
22626646
22969154
23727388
23732084
23922855
24086598
24248381

Gene Ontology  (GO ID)

Biological Process

GO:0070988  demethylation
GO:0019395  fatty acid oxidation
GO:0018393  internal peptidyl-lysine acetylation
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0060192  negative regulation of lipase activity
GO:0043602  nitrate catabolic process
GO:0046210  nitric oxide catabolic process
GO:0055114  oxidation reduction
GO:0045542  positive regulation of cholesterol biosynthetic process
GO:0032332  positive regulation of chondrocyte differentiation
GO:0032770  positive regulation of monooxygenase activity
GO:0045880  positive regulation of smoothened signaling pathway
GO:0090031  positive regulation of steroid hormone biosynthetic process
GO:0090181  regulation of cholesterol metabolic process
GO:0003420  regulation of growth plate cartilage chondrocyte proliferation

Cellular Component

GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0043231  intracellular membrane-bounded organelle
GO:0016020  membrane
GO:0005739  mitochondrion

Molecular Function

GO:0004128  cytochrome-b5 reductase activity
GO:0009055  electron carrier activity
GO:0019899  enzyme binding
GO:0050660  FAD binding
GO:0010181  FMN binding
GO:0016787  hydrolase activity
GO:0005506  iron ion binding
GO:0047726  iron-cytochrome-c reductase activity
GO:0050661  NADP or NADPH binding
GO:0003958  NADPH-hemoprotein reductase activity
GO:0008941  nitric oxide dioxygenase activity
GO:0016491  oxidoreductase activity
GO:0016709  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen