filamin, alpha

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Synonym

Alpha-filamin, F730004A14Rik, Dilp2, Nonmuscle filamin, Actin-binding protein 280, Filamin-A, filamin, alpha, Endothelial actin-binding protein, ABP-280, actin-binding protein 280, Fln, Filamin-1, Flna, Fln1, GENA 379

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:6.91 cerebellum:7.05 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.70 spine:6.83 retina:6.39 eye:7.66 artery/aorta:- vein:11.65 lymphnode:10.15 peripheral blood:- spleen:10.70 thymus:- bone marrow:11.18 adipose:8.93 bone:10.95 skin:9.45
CAGE cerebrum:3.48 cerebellum:- brain stem:3.40 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.40 retina:- eye:- artery/aorta:6.56 vein:- lymphnode:5.26 peripheral blood:- spleen:5.28 thymus:4.82 bone marrow:- adipose:- bone:6.02 skin:4.96
RNA-seq cerebrum:2.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:11.98 placenta:8.63 prostate:10.63 ovary:11.23 testis:7.17 heart:8.94 muscle:8.39 esophagus:- stomach:11.36 intestine:10.62 colon:- liver/hepato:6.77 lung:10.45 bladder:12.96 kidney:7.92 pituitary:7.98 thyroid/parathyroid:- adrenal gland:9.07 pancreas:7.92 breast:9.60 salivary:8.53
CAGE uterus:6.59 placenta:4.95 prostate:5.93 ovary:6.23 testis:2.68 heart:- muscle:- esophagus:- stomach:5.44 intestine:5.35 colon:5.27     liver/hepato:3.05    lung:5.71 bladder:7.75 kidney:- pituitary:3.80 thyroid/parathyroid:- adrenal gland:4.63 pancreas:3.83 breast:5.26 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:5.71 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.03        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010227
Gene ID 192176
Unigene ID -
Probe set ID 1426677_at  [Mouse430_2]
Ensembl ID ENSMUSG00000031328

Orthologous Gene

Human[6]  NM_001110556, NM_001456
Rat[1]  NM_001134599, NM_001456

Chromosomal Region

-

Gene Family (Interpro ID)

IPR016146  Calponin-homology
IPR001715  Calponin-like actin-binding
IPR001298  Filamin/ABP280 repeat
IPR017868  Filamin/ABP280 repeat-like

Link to Pubmed  (Pubmed ID)

7490070
8088838
8756567
8838803
8884278
8889548
8921887
9006895
9096102
9393880
9412467
10349636
10679933
10922068
11042159
11076861
11114196
11217851
11544199
11807098
11929848
12200373
12393796
12466851
12477932
12520002
12704190
12904583
12923176
14691545
15102471
15292205
15306695
15449545
15489334
15509752
15657428
15703188
16141072
16141073
16320251
16602821
16825286
16944949
17145501
17172441
17360453
17510210
17635842
17875933
18201775
18202316
18303054
18548008
18596967
18667433
18824598
18829455
19458194
19759182
19929439
20548051
20549728
20713593
21156842
21169733
21267068
21325628
21359179
21565611
21652675
21677750
21709252
22083510
22121117
22174152
22334688
22546693
22649246
22843703
22857000
22956851
23055941
23161538
23665500
24081490
24089482
24097310
24205360
24403084
24457600
24550283
24614889

Gene Ontology  (GO ID)

Biological Process

GO:0051764  actin crosslink formation
GO:0030036  actin cytoskeleton organization
GO:0031532  actin cytoskeleton reorganization
GO:0030030  cell projection organization
GO:0042384  cilium assembly
GO:0051220  cytoplasmic sequestering of protein
GO:0045022  early endosome to late endosome transport
GO:0001837  epithelial to mesenchymal transition
GO:0045184  establishment of protein localization
GO:0007195  inhibition of adenylate cyclase activity by dopamine receptor signaling pathway
GO:0042789  mRNA transcription from RNA polymerase II promoter
GO:0042177  negative regulation of protein catabolic process
GO:0043433  negative regulation of transcription factor activity
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0042993  positive regulation of transcription factor import into nucleus
GO:0034394  protein localization at cell surface
GO:0050821  protein stabilization
GO:0043113  receptor clustering

Cellular Component

GO:0015629  actin cytoskeleton
GO:0005884  actin filament
GO:0043025  cell soma
GO:0030863  cortical cytoskeleton
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0043198  dendritic shaft
GO:0070062  extracellular vesicular exosome
GO:0031523  Myb complex
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0005802  trans-Golgi network

Molecular Function

GO:0003779  actin binding
GO:0051015  actin filament binding
GO:0034988  Fc-gamma receptor I complex binding
GO:0001948  glycoprotein binding
GO:0031852  mu-type opioid receptor binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0005080  protein kinase C binding
GO:0048365  Rac GTPase binding
GO:0017160  Ral GTPase binding
GO:0017048  Rho GTPase binding
GO:0004871  signal transducer activity
GO:0046332  SMAD binding
GO:0031267  small GTPase binding
GO:0008134  transcription factor binding