PTK2 protein tyrosine kinase 2 beta

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Synonym

calcium-dependent tyrosine kinase, Cell adhesion kinase beta, FADK 2, Ptk2b, PYK2, FAK2, E430023O05Rik, Raftk, Fak2, related adhesion focal tyrosine kinase, proline-rich tyrosine kinase 2, Protein tyrosine kinase 2 beta, CAKB, Proline-rich tyrosine kinase 2, CAK[B], A6, RAFTK, Pyk2, CAK beta, CAKbeta, Related adhesion focal tyrosine kinase, PTK, CADTK, PTK2 protein tyrosine kinase 2 beta, Focal adhesion kinase 2, Calcium-dependent tyrosine kinase, cellular adhesion kinase beta

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.50 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:12.80 adipose:- bone:50.10 skin:7.90
GeneChip cerebrum:10.60 cerebellum:5.65 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.29 spine:5.80 retina:5.70 eye:6.83 artery/aorta:- vein:6.57 lymphnode:10.29 peripheral blood:- spleen:10.58 thymus:- bone marrow:9.05 adipose:7.69 bone:8.82 skin:7.26
CAGE cerebrum:3.79 cerebellum:- brain stem:3.11 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.94 retina:- eye:- artery/aorta:3.80 vein:- lymphnode:4.81 peripheral blood:- spleen:4.16 thymus:4.71 bone marrow:- adipose:- bone:4.25 skin:3.56
RNA-seq cerebrum:61.35 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:13.80 prostate:- ovary:- testis:44.30 heart:- muscle:- esophagus:- stomach:- intestine:37 colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:7.89 placenta:6.55 prostate:6.95 ovary:8.04 testis:7.27 heart:6.66 muscle:5.96 esophagus:- stomach:7.67 intestine:8.42 colon:- liver/hepato:8.02 lung:7.36 bladder:8.44 kidney:8.63 pituitary:8.15 thyroid/parathyroid:- adrenal gland:6.76 pancreas:7.69 breast:7.28 salivary:7.22
CAGE uterus:3.76 placenta:2.26 prostate:3.51 ovary:3.59 testis:1.97 heart:- muscle:- esophagus:- stomach:3.59 intestine:3.50 colon:4.01     liver/hepato:3.76    lung:3.92 bladder:4.33 kidney:- pituitary:4.16 thyroid/parathyroid:- adrenal gland:2.69 pancreas:2.90 breast:2.81 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.32 esophagus:- stomach:- intestine:- colon:-     liver/hepato:8.99        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_172498
Gene ID 19229
Unigene ID Mm.216135
Probe set ID 1434653_at  [Mouse430_2]
Ensembl ID ENSMUSG00000059456

Orthologous Gene

Human[8]  NM_004103, NM_173174, NM_173175, NM_173176
Rat [0]  

Chromosomal Region

14D1  [66,772,094  -  66,899,889]

Gene Family (Interpro ID)

IPR019749  Band 4.1 domain
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7499242
8889548
9774338
9988732
10349636
10469599
10679268
10823839
10862698
10881171
11042159
11076861
11114734
11217851
11238453
11274221
11420674
11493697
11787067
12228222
12466851
12477932
12486027
12514172
12578912
12674328
12771146
12784255
12960403
14500722
14701796
14739300
15096502
15694384
15761030
15782199
15786712
16039993
16141072
16141073
16374517
16391003
16452087
16546139
16602821
16760434
16899073
17526730
17537919
17581824
17684059
17698736
17846174
17967808
18084294
18086875
18195107
18198130
18206965
18391070
18483407
18542050
18635666
19047047
19380485
19416922
19435801
19458494
19520918
19841181
19880522
19955209
20170630
20442405
20688918
20727793
20737507
20805505
20886612
21187437
21195757
21267068
21283581
21471206
21533871
21640103
21666110
22106345
22157654
22342188
22447931
22544749
22800456
22811489
22941736
22984613
23175689
23216754
23362087
23401167
23589331
23640884
23711511
23936270
24105743
24457600
24598361

Gene Ontology  (GO ID)

Biological Process

GO:0007015  actin filament organization
GO:0042976  activation of Janus kinase activity
GO:0032863  activation of Rac GTPase activity
GO:0001525  angiogenesis
GO:0043534  blood vessel endothelial cell migration
GO:0045453  bone resorption
GO:0007155  cell adhesion
GO:0007166  cell surface receptor linked signal transduction
GO:0071300  cellular response to retinoic acid
GO:0070098  chemokine-mediated signaling pathway
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0048041  focal adhesion formation
GO:0007229  integrin-mediated signaling pathway
GO:0000165  MAPKKK cascade
GO:0002315  marginal zone B cell differentiation
GO:0043066  negative regulation of apoptosis
GO:0030502  negative regulation of bone mineralization
GO:0008285  negative regulation of cell proliferation
GO:0010656  negative regulation of muscle cell apoptosis
GO:0045638  negative regulation of myeloid cell differentiation
GO:0030279  negative regulation of ossification
GO:0043267  negative regulation of potassium ion transport
GO:0031175  neuron projection development
GO:0001556  oocyte maturation
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0016310  phosphorylation
GO:0030838  positive regulation of actin filament polymerization
GO:0045766  positive regulation of angiogenesis
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0001954  positive regulation of cell-matrix adhesion
GO:0010595  positive regulation of endothelial cell migration
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0046330  positive regulation of JNK cascade
GO:0043507  positive regulation of JUN kinase activity
GO:0010976  positive regulation of neuron projection development
GO:0051000  positive regulation of nitric-oxide synthase activity
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0045860  positive regulation of protein kinase activity
GO:0045727  positive regulation of translation
GO:0006468  protein amino acid phosphorylation
GO:0050848  regulation of calcium-mediated signaling
GO:0030155  regulation of cell adhesion
GO:0008360  regulation of cell shape
GO:0030826  regulation of cGMP biosynthetic process
GO:0010752  regulation of cGMP-mediated signaling
GO:0032960  regulation of inositol trisphosphate biosynthetic process
GO:0010758  regulation of macrophage chemotaxis
GO:0045428  regulation of nitric oxide biosynthetic process
GO:0051279  regulation of release of sequestered calcium ion into cytosol
GO:0042542  response to hydrogen peroxide
GO:0007172  signal complex assembly
GO:0002040  sprouting angiogenesis
GO:0043149  stress fiber formation
GO:0033209  tumor necrosis factor-mediated signaling pathway
GO:0048010  vascular endothelial growth factor receptor signaling pathway

Cellular Component

GO:0030424  axon
GO:0005938  cell cortex
GO:0030054  cell junction
GO:0042995  cell projection
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005925  focal adhesion
GO:0030426  growth cone
GO:0030027  lamellipodium
GO:0016020  membrane
GO:0045121  membrane raft
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0014069  postsynaptic density

Molecular Function

GO:0043423  3-phosphoinositide-dependent protein kinase binding
GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0004871  signal transducer activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups