SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

 jump to detail

Synonym

Brg1, SW1/SNF, HP1-BP72, SNF2beta, Smarca4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:357.70 cerebellum:202.60 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:57.30 spine:189.10 retina:900 eye:471.10 artery/aorta:- vein:- lymphnode:- peripheral blood:488.80 spleen:65.80 thymus:79 bone marrow:38.50 adipose:- bone:137.80 skin:150.40
GeneChip cerebrum:8.50 cerebellum:8.63 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:8.83 spine:8.66 retina:8.43 eye:7.41 artery/aorta:- vein:8.03 lymphnode:7.92 peripheral blood:- spleen:8.06 thymus:- bone marrow:8.78 adipose:7.95 bone:8.86 skin:8.53
CAGE cerebrum:4.65 cerebellum:- brain stem:4.44 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.43 retina:- eye:- artery/aorta:4.25 vein:- lymphnode:4.59 peripheral blood:- spleen:4.25 thymus:5.05 bone marrow:- adipose:- bone:4.63 skin:4.80
RNA-seq cerebrum:21.42 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:261.70 placenta:138.10 prostate:30.90 ovary:68.90 testis:199.50 heart:111.60 muscle:35.50 esophagus:- stomach:65.50 intestine:147.90 colon:105.70     liver/hepato:18.10        lung:210.90    bladder:- kidney:48.40 pituitary:232.50 thyroid/parathyroid:112.50 adrenal gland:- pancreas:93.80 breast:140.40 salivary:270
GeneChip uterus:8.31 placenta:7.73 prostate:8.74 ovary:8.62 testis:8.89 heart:8.44 muscle:8.58 esophagus:- stomach:8.39 intestine:8.36 colon:- liver/hepato:7.93 lung:8.19 bladder:8.99 kidney:8.15 pituitary:8.52 thyroid/parathyroid:- adrenal gland:8.96 pancreas:7.20 breast:8.09 salivary:9.32
CAGE uterus:4.35 placenta:4.08 prostate:4.53 ovary:4.48 testis:5.62 heart:- muscle:- esophagus:- stomach:4.28 intestine:4.19 colon:4.18     liver/hepato:3.59    lung:4.00 bladder:4.71 kidney:- pituitary:4.20 thyroid/parathyroid:- adrenal gland:4.13 pancreas:4.02 breast:4.13 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.23 esophagus:- stomach:- intestine:- colon:-     liver/hepato:5.38        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_011417
Gene ID 20586
Unigene ID Mm.286593
Probe set ID 1426805_at  [Mouse430_2]
Ensembl ID ENSMUSG00000032187

Orthologous Gene

Human[42]  NM_001128844, NM_001128845, NM_001128846, NM_001128847, NM_001128848, NM_001128849, NM_003072
Rat[1]  NM_134368, NM_001128845, NM_001128846, NM_001128847, NM_001128848, NM_001128849, NM_003072

Chromosomal Region

-

Gene Family (Interpro ID)

IPR014001  DEAD-like helicase, N-terminal
IPR013999  HAS subgroup
IPR014021  Helicase, superfamily 1/2, ATP-binding domain
IPR014012  Helicase/SANT-associated, DNA binding
IPR006562  HSA

Link to Pubmed  (Pubmed ID)

1346755
1825133
7904967
7923370
8647447
8889548
8978696
9315656
9603422
9843504
10204490
10318760
10349636
10922068
11042159
11076861
11163203
11217851
11231080
11604513
11805098
11988099
12110891
12368262
12434308
12466851
12477932
12520002
12637547
12889071
12904583
12932351
14500909
14555651
14610273
14676303
14678824
14681479
15031102
15143161
15525990
15565649
15576411
15618518
15749018
15767674
15782199
15965950
15999204
16141072
16141073
16192310
16287714
16322236
16325481
16330018
16424906
16452305
16602821
16717115
16787967
16800816
16818606
16880268
17043109
17074803
17185421
17194702
17255092
17255939
17438135
17599918
17637742
17640523
17967808
18094026
18206867
18267097
18287559
18303029
18342607
18344520
18454139
18483251
18508913
18799693
18816825
18852284
18955569
19056910
19171905
19180471
19279218
19279220
19288495
19342595
19458193
19483677
19556365
19696073
19781646
19800126
19805516
19906647
20003319
20059953
20129940
20176728
20305087
20362541
20362542
20421421
20485553
20571081
20596014
21095589
21118511
21149256
21262765
21262838
21267068
21304516
21445275
21518954
21586902
21730156
21768360
21785422
21831442
22068056
22083510
22162999
22169041
22192413
22245845
22285184
22290435
22318225
22325351
22354994
22363625
22427636
22495890
22513373
22740088
22770845
22814607
22922362
23028370
23076393
23129809
23281043
23319608
23321680
23332759
23339192
23392668
23406903
23449535
23540691
23602386
23643363
23665500
23698369
23723349
23757284
23785148
23868976
23874858
23922304
23933087
23934214
24025402
24042015
24346698
24421395
24457600
24478402
24561622

Gene Ontology  (GO ID)

Biological Process

GO:0006200  ATP catabolic process
GO:0043044  ATP-dependent chromatin remodeling
GO:0001832  blastocyst growth
GO:0001835  blastocyst hatching
GO:0000902  cell morphogenesis
GO:0016568  chromatin modification
GO:0006338  chromatin remodeling
GO:0060318  definitive erythrocyte differentiation
GO:0010424  DNA methylation on cytosine within a CG sequence
GO:0035116  embryonic hindlimb morphogenesis
GO:0048562  embryonic organ morphogenesis
GO:0048730  epidermis morphogenesis
GO:0030198  extracellular matrix organization
GO:0030900  forebrain development
GO:0007403  glial cell fate determination
GO:0007507  heart development
GO:0060347  heart trabecula formation
GO:0030902  hindbrain development
GO:0043966  histone H3 acetylation
GO:0001701  in utero embryonic development
GO:0030216  keratinocyte differentiation
GO:0001889  liver development
GO:0006346  methylation-dependent chromatin silencing
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0030308  negative regulation of cell growth
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0007399  nervous system development
GO:0022008  neurogenesis
GO:0006334  nucleosome assembly
GO:0006337  nucleosome disassembly
GO:0043923  positive regulation by host of viral transcription
GO:0043388  positive regulation of DNA binding
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006355  regulation of transcription, DNA-dependent
GO:0019827  stem cell maintenance
GO:0006351  transcription, DNA-dependent
GO:0001570  vasculogenesis

Cellular Component

GO:0000792  heterochromatin
GO:0000790  nuclear chromatin
GO:0005719  nuclear euchromatin
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0005726  perichromatin fibrils
GO:0016514  SWI/SNF complex

Molecular Function

GO:0050681  androgen receptor binding
GO:0005524  ATP binding
GO:0016887  ATPase activity
GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0008094  DNA-dependent ATPase activity
GO:0004386  helicase activity
GO:0070577  histone acetyl-lysine binding
GO:0016787  hydrolase activity
GO:0016817  hydrolase activity, acting on acid anhydrides
GO:0016818  hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0003676  nucleic acid binding
GO:0000166  nucleotide binding
GO:0002039  p53 binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0047485  protein N-terminus binding
GO:0030957  Tat protein binding
GO:0003713  transcription coactivator activity
GO:0003714  transcription corepressor activity
GO:0008134  transcription factor binding