transcription factor 7-like 2, T-cell specific, HMG-box

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Synonym

mTcf-4E, Transcription factor 7-like 2, mTcf-4B, Tcf7l2, TCF4E, Tcf-4, TCF4B, TCF-4, T-cell-specific transcription factor 4, mTCF-4, HMG box transcription factor 4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:137.20 cerebellum:18.40 brain stem:444.90 corpus callosum/glia:- pineal gland:257.80 peripheral nerve:19.10 spine:- retina:32.10 eye:38 artery/aorta:337.60 vein:- lymphnode:54 peripheral blood:301.90 spleen:- thymus:128.40 bone marrow:12.80 adipose:425.40 bone:37.60 skin:23.80
GeneChip cerebrum:5.29 cerebellum:4.39 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.45 spine:4.73 retina:5.35 eye:5.44 artery/aorta:- vein:7.08 lymphnode:5.77 peripheral blood:- spleen:6.11 thymus:- bone marrow:5.37 adipose:6.24 bone:6.01 skin:6.28
CAGE cerebrum:3.11 cerebellum:- brain stem:4.46 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.16 retina:- eye:- artery/aorta:4.94 vein:- lymphnode:4.81 peripheral blood:- spleen:4.06 thymus:3.18 bone marrow:- adipose:- bone:3.41 skin:5.18
RNA-seq cerebrum:2.64 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:13.80 prostate:30.90 ovary:- testis:7.40 heart:74.40 muscle:- esophagus:- stomach:294.60 intestine:- colon:105.70     liver/hepato:-        lung:100.40    bladder:132.40 kidney:72.50 pituitary:116.30 thyroid/parathyroid:112.50 adrenal gland:- pancreas:187.60 breast:84.90 salivary:54
GeneChip uterus:6.47 placenta:5.91 prostate:6.99 ovary:7.04 testis:4.04 heart:5.49 muscle:5.51 esophagus:- stomach:7.28 intestine:8.04 colon:- liver/hepato:6.79 lung:6.58 bladder:6.33 kidney:5.74 pituitary:5.39 thyroid/parathyroid:- adrenal gland:6.30 pancreas:4.56 breast:7.32 salivary:5.71
CAGE uterus:4.17 placenta:4.23 prostate:4.85 ovary:4.53 testis:3.31 heart:- muscle:- esophagus:- stomach:4.42 intestine:4.89 colon:5.26     liver/hepato:4.35    lung:4.26 bladder:4.45 kidney:- pituitary:3.71 thyroid/parathyroid:- adrenal gland:3.84 pancreas:4.41 breast:5.99 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.12 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.81        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001142918
Gene ID 21416
Unigene ID Mm.139815
Probe set ID 1429428_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024985

Orthologous Gene

Human[36]  NM_001146274, NM_001146283, NM_001146284, NM_001146285, NM_001146286, NM_001198525, NM_001198526, NM_001198527, NM_001198528, NM_001198529, NM_001198531, NM_030756
Rat [0]  

Chromosomal Region

19D2  [55,816,300  -  56,008,144]

Gene Family (Interpro ID)

IPR000910  High mobility group, HMG1/HMG2
IPR009071  High mobility group, superfamily

Link to Pubmed  (Pubmed ID)

9488439
9697701
9784592
9792805
9880534
10027409
10090727
10349636
10528152
10631168
10821773
10937998
11042159
11076861
11217851
11404013
11493561
11731265
11845287
12361972
12466851
12477932
12520002
12861022
12874278
12907761
14610273
14667415
14681479
15037319
15057272
15102471
15186480
15201223
15226261
15226823
15342465
15342729
15576399
15576404
15578569
15618518
15736266
15778706
15866165
15917450
16027046
16141072
16141073
16192304
16204248
16210377
16407833
16602821
16644143
16678101
16724116
16950124
16971467
17053159
17065530
17257418
17335794
17362910
17366625
17596282
17607356
17681174
17699607
17727834
17919533
17920061
17953485
17967808
18094027
18270576
18287559
18351662
18481957
18554416
18635608
18799693
19125404
19165927
19168596
19213727
19251639
19303461
19304756
19386626
19468708
19487454
19503085
19515692
19515974
19525957
19542358
19700620
19718027
19741146
19780901
19805521
19845015
19892877
19898815
19924825
20044351
20059953
20412781
20459822
20637749
20660756
20803090
20816794
20883686
20889500
20932939
21177349
21228006
21246658
21247964
21267068
21335239
21362171
21383188
21452227
21525287
21673050
21677750
21775418
21821099
21828091
21856776
21935430
22046400
22102609
22160878
22166339
22393260
22421044
22573616
22717537
22719219
22796301
22966074
22967502
23028378
23152144
23260145
23824574
23863478
23912999
24463605
24670930

Gene Ontology  (GO ID)

Biological Process

GO:0001568  blood vessel development
GO:0030282  bone mineralization
GO:0007050  cell cycle arrest
GO:0008283  cell proliferation
GO:0048557  embryonic digestive tract morphogenesis
GO:0030538  embryonic genitalia morphogenesis
GO:0048619  embryonic hindgut morphogenesis
GO:0060325  face morphogenesis
GO:0045444  fat cell differentiation
GO:0042593  glucose homeostasis
GO:0043570  maintenance of DNA repeat elements
GO:0048625  myoblast cell fate commitment
GO:0030514  negative regulation of BMP signaling pathway
GO:0045599  negative regulation of fat cell differentiation
GO:0040037  negative regulation of fibroblast growth factor receptor signaling pathway
GO:0046621  negative regulation of organ growth
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0021915  neural tube development
GO:0042475  odontogenesis of dentine-containing tooth
GO:0014003  oligodendrocyte development
GO:0021983  pituitary gland development
GO:0043065  positive regulation of apoptosis
GO:0050679  positive regulation of epithelial cell proliferation
GO:0010909  positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0032024  positive regulation of insulin secretion
GO:0032092  positive regulation of protein binding
GO:0046827  positive regulation of protein export from nucleus
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0032350  regulation of hormone metabolic process
GO:0031641  regulation of myelination
GO:0048713  regulation of oligodendrocyte differentiation
GO:0048641  regulation of skeletal muscle tissue development
GO:0048660  regulation of smooth muscle cell proliferation
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0006355  regulation of transcription, DNA-dependent
GO:0009749  response to glucose stimulus
GO:0032252  secretory granule localization
GO:0043588  skin development
GO:0035019  somatic stem cell maintenance
GO:0006351  transcription, DNA-dependent
GO:0016055  Wnt receptor signaling pathway
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0070369  beta-catenin-TCF7L2 complex
GO:0005829  cytosol
GO:0000790  nuclear chromatin
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0032993  protein-DNA complex
GO:0005667  transcription factor complex

Molecular Function

GO:0070016  armadillo repeat domain binding
GO:0008013  beta-catenin binding
GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0045295  gamma-catenin binding
GO:0035257  nuclear hormone receptor binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding