transforming growth factor, beta 3

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Synonym

MGC118722, Transforming growth factor beta-3 precursor, Tgfb-3, TGF-beta-3, transforming growth factor, beta 3, Tgfb3

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:73.70

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:6.49

cerebellum:6.99

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:7.26

spine:7.77

retina:6.48

eye:7.53

artery/aorta:-

vein:10.12

lymphnode:6.54

peripheral blood:-

spleen:5.56

thymus:-

bone marrow:5.01

adipose:7.47

bone:6.64

skin:6.75

CAGE

cerebrum:1.68

cerebellum:-

brain stem:1.85

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:2.43

retina:-

eye:-

artery/aorta:2.82

vein:-

lymphnode:1.41

peripheral blood:-

spleen:0.41

thymus:0.82

bone marrow:-

adipose:-

bone:1.02

skin:2.09

RNA-seq

cerebrum:2.02

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:22.20

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:8.53

placenta:9.14

prostate:7.49

ovary:8.65

testis:6.69

heart:7.58

muscle:8.75

esophagus:-

stomach:6.48

intestine:6.44

colon:-

liver/hepato:5.77

lung:8.38

bladder:9.74

kidney:5.36

pituitary:6.93

thyroid/parathyroid:-

adrenal gland:7.05

pancreas:6.66

breast:9.40

salivary:7.11

CAGE

uterus:2.20

placenta:2.72

prostate:2.37

ovary:2.67

testis:0.75

heart:-

muscle:-

esophagus:-

stomach:0.67

intestine:0.72

colon:1.11

liver/hepato:0.26

lung:2.57

bladder:3.33

kidney:-

pituitary:0.99

thyroid/parathyroid:-

adrenal gland:1.98

pancreas:1.30

breast:2.90

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:2.88

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:1.54

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_009368
Gene ID	21809
Unigene ID	Mm.399200
Probe set ID	1417455_at [Mouse430_2]
Ensembl ID	ENSMUSG00000021253

Orthologous Gene

Human[1]	NM_003239
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

IPR001111	Transforming growth factor beta (TGFb), N-terminal
IPR015618	Transforming growth factor beta 3
IPR003911	Transforming growth factor beta TGFb
IPR003940	Transforming growth factor, beta 2
IPR016319	Transforming growth factor-beta
IPR015615	Transforming growth factor-beta-related

Gene Ontology (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0016049	cell growth
GO:0045216	cell-cell junction organization
GO:0071363	cellular response to growth factor stimulus
GO:0070483	detection of hypoxia
GO:0009790	embryonic development
GO:0048702	embryonic neurocranium morphogenesis
GO:0060325	face morphogenesis
GO:0040007	growth
GO:0001701	in utero embryonic development
GO:0048286	lung alveolus development
GO:0030879	mammary gland development
GO:0008285	negative regulation of cell proliferation
GO:0008156	negative regulation of DNA replication
GO:0010936	negative regulation of macrophage cytokine production
GO:0043524	negative regulation of neuron apoptosis
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0009887	organ morphogenesis
GO:0060021	palate development
GO:0043065	positive regulation of apoptosis
GO:0051781	positive regulation of cell division
GO:0032967	positive regulation of collagen biosynthetic process
GO:0045740	positive regulation of DNA replication
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0051491	positive regulation of filopodium assembly
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0050714	positive regulation of protein secretion
GO:0060391	positive regulation of SMAD protein nuclear translocation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0043627	response to estrogen stimulus
GO:0001666	response to hypoxia
GO:0032570	response to progesterone stimulus
GO:0007184	SMAD protein nuclear translocation
GO:0007179	transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0043025	cell soma
GO:0009986	cell surface
GO:0005737	cytoplasm
GO:0031012	extracellular matrix
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0030141	secretory granule
GO:0030315	T-tubule

Molecular Function

GO:0008083	growth factor activity
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity
GO:0050431	transforming growth factor beta binding
GO:0005160	transforming growth factor beta receptor binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0005114	type II transforming growth factor beta receptor binding

transforming growth factor, beta 3

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function