tumor necrosis factor, alpha-induced protein 3

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Synonym

Tnfaip3, A20, tumor necrosis factor, alpha-induced protein 3, Tumor necrosis factor, alpha-induced protein 3, Tnfip3, Putative DNA-binding protein A20, Zinc finger protein A20, zinc finger protein A20

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:19.10 spine:- retina:32.10 eye:106.40 artery/aorta:168.80 vein:- lymphnode:421.30 peripheral blood:1351.40 spleen:2554.30 thymus:98.80 bone marrow:320.50 adipose:212.70 bone:125.20 skin:23.80
GeneChip nodata
CAGE cerebrum:0.94 cerebellum:- brain stem:0.89 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.91 retina:- eye:- artery/aorta:1.94 vein:- lymphnode:4.28 peripheral blood:- spleen:3.02 thymus:3.85 bone marrow:- adipose:- bone:2.37 skin:2.58
RNA-seq cerebrum:1.46 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:55.20 prostate:- ovary:- testis:- heart:- muscle:71 esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.10        lung:20.10    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:18.80 breast:26.10 salivary:-
GeneChip nodata
CAGE uterus:2.82 placenta:2.00 prostate:1.69 ovary:1.42 testis:0.75 heart:- muscle:- esophagus:- stomach:1.57 intestine:2.33 colon:2.82     liver/hepato:1.38    lung:2.89 bladder:1.69 kidney:- pituitary:1.69 thyroid/parathyroid:- adrenal gland:1.85 pancreas:2.03 breast:2.11 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.04 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.68        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001166402
Gene ID 21929
Unigene ID Mm.116683
Probe set ID -
Ensembl ID ENSMUSG00000019850

Orthologous Gene

Human[2]  NM_006290
Rat[2]  NM_006290

Chromosomal Region

10A3  [18,720,716  -  18,735,463]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7836754
9610637
10349636
10385526
11009421
11042159
11076861
11217851
11390377
11544199
11973313
12466851
12477932
12586352
14614151
15102471
15226823
15334086
15618518
15962316
16141072
16141073
16919269
16936197
17389268
17703191
17709380
17982095
18006655
18223652
18239685
18246070
18268035
18287559
18342009
18676814
18952128
19252225
19412163
19570823
19826422
19877201
19912257
20059953
20185725
20211142
20430393
20501938
20530205
20577653
20705491
21088135
21151899
21167234
21206085
21321094
21335489
21341261
21566665
21723156
21765415
21841782
21885437
21934070
22012122
22019834
22031828
22173278
22396652
22595989
22685311
22736257
22826618
22975135
23029542
23032187
23145026
23238769
23602765
23609450
23671587
23677497
24012418
24023826
24055365
24236890
24453940
24487321
24859449

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0001922  B-1 B cell homeostasis
GO:0070301  cellular response to hydrogen peroxide
GO:0071222  cellular response to lipopolysaccharide
GO:0006954  inflammatory response
GO:0002315  marginal zone B cell differentiation
GO:0008152  metabolic process
GO:0010507  negative regulation of autophagy
GO:0050869  negative regulation of B cell activation
GO:0060548  negative regulation of cell death
GO:0002677  negative regulation of chronic inflammatory response
GO:0045736  negative regulation of cyclin-dependent protein kinase activity
GO:0002632  negative regulation of granuloma formation
GO:0034115  negative regulation of heterotypic cell-cell adhesion
GO:0043124  negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0050728  negative regulation of inflammatory response
GO:0045824  negative regulation of innate immune response
GO:0032691  negative regulation of interleukin-1 beta production
GO:0032703  negative regulation of interleukin-2 production
GO:0032715  negative regulation of interleukin-6 production
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0070429  negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433  negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397  negative regulation of protein ubiquitination
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0034140  negative regulation of toll-like receptor 3 signaling pathway
GO:0034148  negative regulation of toll-like receptor 5 signaling pathway
GO:0032720  negative regulation of tumor necrosis factor production
GO:0045732  positive regulation of protein catabolic process
GO:0016579  protein deubiquitination
GO:0070936  protein K48-linked ubiquitination
GO:0070536  protein K63-linked deubiquitination
GO:0006508  proteolysis
GO:0002634  regulation of germinal center formation
GO:0002637  regulation of immunoglobulin production
GO:0045088  regulation of innate immune response
GO:0002237  response to molecule of bacterial origin
GO:0032495  response to muramyl dipeptide
GO:0009611  response to wounding

Cellular Component

GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0005764  lysosome
GO:0005634  nucleus

Molecular Function

GO:0003824  catalytic activity
GO:0008234  cysteine-type peptidase activity
GO:0003677  DNA binding
GO:0016787  hydrolase activity
GO:0019900  kinase binding
GO:0016874  ligase activity
GO:0046872  metal ion binding
GO:0008233  peptidase activity
GO:0002020  protease binding
GO:0005515  protein binding
GO:0043621  protein self-association
GO:0043130  ubiquitin binding
GO:0004221  ubiquitin thiolesterase activity
GO:0004842  ubiquitin-protein ligase activity
GO:0004843  ubiquitin-specific protease activity
GO:0008270  zinc ion binding