ubiquitin-conjugating enzyme E2B, RAD6 homology (S. cerevisiae)

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Synonym

E2-14k, Ube2b, E214K, HR6B, Ubiquitin-conjugating enzyme E2 B, 2610301N02Rik, Rad6b, Ubiquitin-protein ligase B, Ubiquitin carrier protein B

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:11.03 cerebellum:10.33 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:11.20 spine:10.03 retina:8.41 eye:8.96 artery/aorta:- vein:11 lymphnode:10.69 peripheral blood:- spleen:10.68 thymus:- bone marrow:11.67 adipose:10.98 bone:11.41 skin:11.20
CAGE cerebrum:5.16 cerebellum:- brain stem:5.09 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.95 retina:- eye:- artery/aorta:5.34 vein:- lymphnode:4.65 peripheral blood:- spleen:5.23 thymus:4.90 bone marrow:- adipose:- bone:5.40 skin:5.09
RNA-seq cerebrum:20.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:9.40 breast:- salivary:-
GeneChip uterus:10.65 placenta:11.06 prostate:10.77 ovary:10.84 testis:11.25 heart:11.80 muscle:12.67 esophagus:- stomach:10.30 intestine:10.34 colon:- liver/hepato:10.64 lung:10.85 bladder:10.88 kidney:10.25 pituitary:11.23 thyroid/parathyroid:- adrenal gland:10.59 pancreas:9.86 breast:11.54 salivary:9.68
CAGE uterus:4.70 placenta:5.05 prostate:4.95 ovary:4.85 testis:6.39 heart:- muscle:- esophagus:- stomach:5.14 intestine:4.57 colon:4.74     liver/hepato:5.07    lung:5.13 bladder:5.06 kidney:- pituitary:5.28 thyroid/parathyroid:- adrenal gland:4.88 pancreas:4.71 breast:4.52 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:87.80 esophagus:- stomach:- intestine:- colon:-     liver/hepato:11.93        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_009458
Gene ID 22210
Unigene ID Mm.384918
Probe set ID 1423107_at  [Mouse430_2]
Ensembl ID ENSMUSG00000020390

Orthologous Gene

Human[4]  NM_003337
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000608  Ubiquitin-conjugating enzyme, E2
IPR016135  Ubiquitin-conjugating enzyme/RWD-like

Link to Pubmed  (Pubmed ID)

1559696
2538923
7590289
7613042
8797826
8889548
8910481
9502196
9922113
10068466
10349636
10805755
11042159
11076861
11217851
12169441
12360237
12466851
12477932
12509447
12520002
12556476
12672659
12784252
14585983
14610273
15169909
15383616
15657431
15782199
16141072
16141073
17010969
17462990
17488778
17720710
17967808
18339854
18799693
20537150
21267068
21677750
21807948
23525009
23863405

Gene Ontology  (GO ID)

Biological Process

GO:0051026  chiasma formation
GO:0006281  DNA repair
GO:0033522  histone H2A ubiquitination
GO:0070076  histone lysine demethylation
GO:0001701  in utero embryonic development
GO:0006344  maintenance of chromatin silencing
GO:0008152  metabolic process
GO:0043066  negative regulation of apoptosis
GO:0043951  negative regulation of cAMP-mediated signaling
GO:0033128  negative regulation of histone phosphorylation
GO:0010845  positive regulation of reciprocal meiotic recombination
GO:0006301  postreplication repair
GO:0043161  proteasomal ubiquitin-dependent protein catabolic process
GO:0051865  protein autoubiquitination
GO:0070979  protein K11-linked ubiquitination
GO:0070936  protein K48-linked ubiquitination
GO:0070534  protein K63-linked ubiquitination
GO:0006513  protein monoubiquitination
GO:0000209  protein polyubiquitination
GO:0050821  protein stabilization
GO:0016567  protein ubiquitination
GO:0031056  regulation of histone modification
GO:0006974  response to DNA damage stimulus
GO:0042493  response to drug
GO:0009411  response to UV
GO:0007288  sperm axoneme assembly
GO:0007283  spermatogenesis
GO:0070193  synaptonemal complex organization
GO:0006511  ubiquitin-dependent protein catabolic process
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0000785  chromatin
GO:0005737  cytoplasm
GO:0033503  HULC complex
GO:0016020  membrane
GO:0000790  nuclear chromatin
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0005657  replication fork
GO:0001741  XY body

Molecular Function

GO:0016881  acid-amino acid ligase activity
GO:0005524  ATP binding
GO:0016874  ligase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0031625  ubiquitin protein ligase binding
GO:0004842  ubiquitin-protein ligase activity