mitogen-activated protein kinase kinase 1

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Synonym

Mek1, MAP kinase kinase 1, MAPK/ERK kinase 1, Prkmk1, ERK activator kinase 1, MAPKK1, MEK1, mitogen activated protein kinase kinase 1, MAPKK 1, MEKK1, Map2k1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:194.50 cerebellum:- brain stem:254.20 corpus callosum/glia:- pineal gland:- peripheral nerve:210.20 spine:- retina:128.60 eye:121.60 artery/aorta:- vein:- lymphnode:172.80 peripheral blood:43.10 spleen:144.80 thymus:98.80 bone marrow:38.50 adipose:- bone:62.60 skin:87.10
GeneChip cerebrum:11.34 cerebellum:10.23 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:10.32 spine:9.89 retina:9.55 eye:9 artery/aorta:- vein:9.29 lymphnode:9.82 peripheral blood:- spleen:9.93 thymus:- bone marrow:9.25 adipose:9.18 bone:9.23 skin:8.43
CAGE cerebrum:4.71 cerebellum:- brain stem:4.53 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:4.33 retina:- eye:- artery/aorta:3.69 vein:- lymphnode:4.09 peripheral blood:- spleen:3.73 thymus:3.41 bone marrow:- adipose:- bone:3.94 skin:3.54
RNA-seq cerebrum:38.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:174.50 placenta:193.30 prostate:30.90 ovary:252.80 testis:36.90 heart:260.40 muscle:71 esophagus:- stomach:32.70 intestine:- colon:105.70     liver/hepato:-        lung:100.40    bladder:132.40 kidney:64.50 pituitary:25.80 thyroid/parathyroid:- adrenal gland:- pancreas:46.90 breast:81.60 salivary:-
GeneChip uterus:9.27 placenta:10.60 prostate:9.01 ovary:9.33 testis:6.40 heart:9.02 muscle:9.77 esophagus:- stomach:10.51 intestine:10.35 colon:- liver/hepato:9.32 lung:9.37 bladder:9.63 kidney:8.94 pituitary:9.85 thyroid/parathyroid:- adrenal gland:9.11 pancreas:8.77 breast:9.21 salivary:8.43
CAGE uterus:4.05 placenta:4.40 prostate:3.58 ovary:3.72 testis:2.05 heart:- muscle:- esophagus:- stomach:4.28 intestine:4.41 colon:4.38     liver/hepato:3.97    lung:3.81 bladder:3.82 kidney:- pituitary:4.01 thyroid/parathyroid:- adrenal gland:3.87 pancreas:2.66 breast:3.68 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:13.98 esophagus:- stomach:- intestine:- colon:-     liver/hepato:6.76        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008927
Gene ID 26395
Unigene ID Mm.248907
Probe set ID 1416351_at  [Mouse430_2]
Ensembl ID ENSMUSG00000004936

Orthologous Gene

Human[1]  NM_002755
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1381507
1411546
7914033
8168826
8297798
8385802
8388392
8602221
8602223
8631303
8632902
9149902
9155017
9208850
9427629
9440696
9563949
9806642
9852579
10209122
10349636
10725249
10838075
10862698
10917603
11042159
11076861
11101507
11217851
11222509
11823472
11841548
12244094
12270934
12466851
12477932
12522145
12532330
12612072
12663500
12788225
12832465
12875843
12904583
14563325
14594209
14610273
14627958
14681479
14871928
15004527
15118098
15145949
15159407
15240686
15304090
15305288
15489334
15509711
15546878
15647843
15701678
15782199
15890671
15896720
16141072
16141073
16148006
16162927
16199873
16424016
16463380
16686604
16761309
16887817
16908534
16931773
17110930
17210639
17396120
17419998
17507801
17707671
17951252
17967808
17972914
18203667
18332145
18483625
18555587
18619436
18632602
18799693
18838072
18952847
19017799
19023081
19029245
19038858
19144315
19198628
19219045
19243475
19304888
19321662
19383924
19551815
19565474
19628790
19733237
19734904
20019329
20308572
20530870
20710027
20884876
20956560
21041641
21144847
21267068
21310925
21336309
21383153
21439396
21454680
21478499
21498542
21514245
21527500
21965329
22056560
22164275
22393900
22465219
22491947
22549869
22561024
22723831
22821618
22904158
22919064
22922362
22998872
23453810
23468876
23469020
23480967
23637887
23727409
23735655
23945236
24126911
24457600
24746703

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0007050  cell cycle arrest
GO:0048870  cell motility
GO:0008283  cell proliferation
GO:0048313  Golgi inheritance
GO:0030216  keratinocyte differentiation
GO:0060711  labyrinthine layer development
GO:0000165  MAPKKK cascade
GO:0032402  melanosome transport
GO:0007067  mitosis
GO:0008285  negative regulation of cell proliferation
GO:0034111  negative regulation of homotypic cell-cell adhesion
GO:0030182  neuron differentiation
GO:0048812  neuron projection morphogenesis
GO:0016310  phosphorylation
GO:0060674  placenta blood vessel development
GO:0045597  positive regulation of cell differentiation
GO:0030335  positive regulation of cell migration
GO:0032320  positive regulation of Ras GTPase activity
GO:0046579  positive regulation of Ras protein signal transduction
GO:0032968  positive regulation of RNA elongation from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation
GO:0051291  protein heterooligomerization
GO:0090170  regulation of Golgi inheritance
GO:0032872  regulation of stress-activated MAPK cascade
GO:0003056  regulation of vascular smooth muscle contraction
GO:0048678  response to axon injury
GO:0051384  response to glucocorticoid stimulus
GO:0006979  response to oxidative stress
GO:0047496  vesicle transport along microtubule

Cellular Component

GO:0033267  axon part
GO:0005938  cell cortex
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0030425  dendrite
GO:0032839  dendrite cytoplasm
GO:0005769  early endosome
GO:0005925  focal adhesion
GO:0005794  Golgi apparatus
GO:0005770  late endosome
GO:0005874  microtubule
GO:0005739  mitochondrion
GO:0005634  nucleus
GO:0043204  perikaryon
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0004708  MAP kinase kinase activity
GO:0031435  mitogen-activated protein kinase kinase kinase binding
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0043539  protein serine/threonine kinase activator activity
GO:0004674  protein serine/threonine kinase activity
GO:0004712  protein serine/threonine/tyrosine kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0017016  Ras GTPase binding
GO:0004728  receptor signaling protein tyrosine phosphatase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups