activin A receptor, type IC

 jump to detail

Synonym

ALK-7, Activin receptor-like kinase 7, C230097P10, Acvr1c, Activin receptor type 1C precursor, ACVRLK7, Alk-7, activin A receptor, type IC, Alk7, ALK7, ACTR-IC

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.40 cerebellum:36.80 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:19.10 spine:- retina:- eye:- artery/aorta:928.30 vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.12 cerebellum:5.04 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.84 spine:4.94 retina:4.80 eye:5.07 artery/aorta:- vein:4.69 lymphnode:4.79 peripheral blood:- spleen:4.88 thymus:- bone marrow:4.79 adipose:7.10 bone:4.84 skin:4.95
CAGE cerebrum:1.67 cerebellum:- brain stem:1.42 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.33 retina:- eye:- artery/aorta:4.14 vein:- lymphnode:1.12 peripheral blood:- spleen:0 thymus:0.82 bone marrow:- adipose:- bone:1.02 skin:1.91
RNA-seq cerebrum:1.75 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:11.50 testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:20.10    bladder:264.70 kidney:- pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:13.10 salivary:-
GeneChip uterus:4.77 placenta:4.88 prostate:4.84 ovary:5.23 testis:4.85 heart:5.19 muscle:5.23 esophagus:- stomach:4.98 intestine:4.82 colon:- liver/hepato:5.09 lung:4.58 bladder:4.90 kidney:4.97 pituitary:4.92 thyroid/parathyroid:- adrenal gland:5.20 pancreas:5.13 breast:5.34 salivary:4.89
CAGE uterus:0.31 placenta:0 prostate:0.51 ovary:2.25 testis:0 heart:- muscle:- esophagus:- stomach:0 intestine:1.36 colon:1.19     liver/hepato:0    lung:0.17 bladder:2.10 kidney:- pituitary:1.63 thyroid/parathyroid:- adrenal gland:2.26 pancreas:2.45 breast:2.34 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.32 esophagus:- stomach:- intestine:- colon:-     liver/hepato:0        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001033369
Gene ID 269275
Unigene ID Mm.77751
Probe set ID 1428032_at  [Mouse430_2]
Ensembl ID ENSMUSG00000026834

Orthologous Gene

Human[4]  NM_001111031, NM_001111032, NM_001111033, NM_145259
Rat [0]  

Chromosomal Region

2C1.1  [58,119,864  -  58,210,306]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

10349636
11042159
11076861
11217851
12466851
12477932
14729481
15196700
15342483
15485907
15489334
16141072
16141073
16564040
16602821
16845371
16953060
18077674
18241853
18287559
18480258
18480259
21267068
21731673
22056140
22550067
22585713
22933117
22954591
23034635
23264230
23342175

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0030262  apoptotic nuclear changes
GO:0030154  cell differentiation
GO:0007368  determination of left/right symmetry
GO:0001701  in utero embryonic development
GO:0019915  lipid storage
GO:0046676  negative regulation of insulin secretion
GO:0016310  phosphorylation
GO:0043065  positive regulation of apoptosis
GO:0043280  positive regulation of caspase activity
GO:0006468  protein amino acid phosphorylation
GO:0042981  regulation of apoptosis
GO:0002021  response to dietary excess
GO:0009749  response to glucose stimulus
GO:0032868  response to insulin stimulus
GO:0007181  transforming growth factor beta receptor complex assembly
GO:0007178  transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0001834  trophectodermal cell proliferation

Cellular Component

GO:0048179  activin receptor complex
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0048185  activin binding
GO:0016361  activin receptor activity, type I
GO:0005524  ATP binding
GO:0070700  BMP receptor binding
GO:0016301  kinase activity
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0005024  transforming growth factor beta receptor activity
GO:0004675  transmembrane receptor protein serine/threonine kinase activity