smoothened homolog (Drosophila)

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Synonym

Smoothened homolog precursor, Smo, Smoh, smoothened homolog (Drosophila), bnb, D13Mgi8, E130215L21Rik, SMO

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:71.20

cerebellum:55.30

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:64.30

eye:98.80

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:43.10

spleen:-

thymus:19.80

bone marrow:12.80

adipose:-

bone:50.10

skin:15.80

GeneChip

cerebrum:7.24

cerebellum:7.40

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:7.14

spine:8.08

retina:8.20

eye:8.68

artery/aorta:-

vein:8.57

lymphnode:6.98

peripheral blood:-

spleen:7.14

thymus:-

bone marrow:6.55

adipose:8.10

bone:7.03

skin:8.55

CAGE

cerebrum:2.00

cerebellum:-

brain stem:2.06

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:2.60

retina:-

eye:-

artery/aorta:2.24

vein:-

lymphnode:1.03

peripheral blood:-

spleen:1.27

thymus:2.84

bone marrow:-

adipose:-

bone:1.30

skin:3.06

RNA-seq

cerebrum:2.80

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:43.60

placenta:13.80

prostate:-

ovary:23

testis:7.40

heart:-

muscle:-

esophagus:-

stomach:32.70

intestine:37

colon:70.50

liver/hepato:18.10

lung:40.20

bladder:-

kidney:24.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:131.40

breast:58.80

salivary:-

GeneChip

uterus:9.84

placenta:6.90

prostate:7.91

ovary:9.79

testis:7.22

heart:7.91

muscle:7.15

esophagus:-

stomach:8.20

intestine:7.66

colon:-

liver/hepato:7.25

lung:8.16

bladder:8.78

kidney:9.18

pituitary:7.37

thyroid/parathyroid:-

adrenal gland:9.07

pancreas:7.27

breast:8.11

salivary:8.42

CAGE

uterus:3.36

placenta:1.38

prostate:1.77

ovary:3.57

testis:0.45

heart:-

muscle:-

esophagus:-

stomach:2.16

intestine:1.29

colon:1.81

liver/hepato:1.02

lung:2.36

bladder:3.08

kidney:-

pituitary:1.48

thyroid/parathyroid:-

adrenal gland:3.07

pancreas:2.03

breast:2.32

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.29

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:4.54

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_176996
Gene ID	319757
Unigene ID	Mm.29279
Probe set ID	1427048_at [Mouse430_2]
Ensembl ID	ENSMUSG00000001761

Orthologous Gene

Human[1]	NM_005631
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

IPR000539	Frizzled protein
IPR020067	Frizzled-like domain
IPR017981	GPCR, family 2-like

Gene Ontology (GO ID)

Biological Process

GO:0021984	adenohypophysis development
GO:0048846	axon extension involved in axon guidance
GO:0010002	cardioblast differentiation
GO:0048468	cell development
GO:0001708	cell fate specification
GO:0007166	cell surface receptor linked signal transduction
GO:0007417	central nervous system development
GO:0021953	central nervous system neuron differentiation
GO:0021696	cerebellar cortex morphogenesis
GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway
GO:0060248	detection of cell density by contact stimulus involved in contact inhibition
GO:0003140	determination of left/right asymmetry in lateral mesoderm
GO:0007368	determination of left/right symmetry
GO:0048589	developmental growth
GO:0021904	dorsal/ventral neural tube patterning
GO:0009953	dorsal/ventral pattern formation
GO:0031076	embryonic camera-type eye development
GO:0048557	embryonic digestive tract morphogenesis
GO:0048702	embryonic neurocranium morphogenesis
GO:0048703	embryonic viscerocranium morphogenesis
GO:0060684	epithelial-mesenchymal cell signaling
GO:0031017	exocrine pancreas development
GO:0021561	facial nerve development
GO:0021508	floor plate formation
GO:0048853	forebrain morphogenesis
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0008406	gonad development
GO:0048565	gut development
GO:0031069	hair follicle morphogenesis
GO:0001947	heart looping
GO:0003007	heart morphogenesis
GO:0001701	in utero embryonic development
GO:0060644	mammary gland epithelial cell differentiation
GO:0007494	midgut development
GO:0035264	multicellular organism growth
GO:0007275	multicellular organismal development
GO:0042693	muscle cell fate commitment
GO:0043066	negative regulation of apoptosis
GO:0043392	negative regulation of DNA binding
GO:0030857	negative regulation of epithelial cell differentiation
GO:0010629	negative regulation of gene expression
GO:0051799	negative regulation of hair follicle development
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001755	neural crest cell migration
GO:0048663	neuron fate commitment
GO:0031102	neuron projection regeneration
GO:0042475	odontogenesis of dentine-containing tooth
GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0032474	otolith morphogenesis
GO:0003323	pancreatic B cell development
GO:0007389	pattern specification process
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:0008284	positive regulation of cell proliferation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0010628	positive regulation of gene expression
GO:0007228	positive regulation of hh target transcription factor activity
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002052	positive regulation of neuroblast proliferation
GO:0042307	positive regulation of protein import into nucleus
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0034504	protein localization in nucleus
GO:0050821	protein stabilization
GO:0010468	regulation of gene expression
GO:0048752	semicircular canal morphogenesis
GO:0007165	signal transduction
GO:0007224	smoothened signaling pathway
GO:0021938	smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation
GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning
GO:0007283	spermatogenesis
GO:0021794	thalamus development
GO:0001570	vasculogenesis
GO:0007371	ventral midline determination
GO:0060070	Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0005901	caveola
GO:0043025	cell soma
GO:0005929	cilium
GO:0060170	cilium membrane
GO:0005737	cytoplasm
GO:0030425	dendrite
GO:0005794	Golgi apparatus
GO:0016021	integral to membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0016020	membrane
GO:0005886	plasma membrane
GO:0014069	postsynaptic density

Molecular Function

GO:0008144	drug binding
GO:0004930	G-protein coupled receptor activity
GO:0005113	patched binding
GO:0030165	PDZ domain binding
GO:0004871	signal transducer activity
GO:0004888	transmembrane receptor activity
GO:0042813	Wnt receptor activity
GO:0017147	Wnt-protein binding

smoothened homolog (Drosophila)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function