PHD finger protein 8

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Synonym

PHD finger protein 8, Kiaa1111, mKIAA1111, Phf8, 9830141C09Rik

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:66 cerebellum:92.10 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:19.10 spine:47.30 retina:64.30 eye:76 artery/aorta:337.60 vein:- lymphnode:21.60 peripheral blood:28.80 spleen:- thymus:148.20 bone marrow:- adipose:- bone:50.10 skin:47.50
GeneChip cerebrum:7.05 cerebellum:7.42 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.87 spine:6.56 retina:8.14 eye:7.74 artery/aorta:- vein:7.25 lymphnode:7.82 peripheral blood:- spleen:8.01 thymus:- bone marrow:8.33 adipose:7.49 bone:7.95 skin:6.81
CAGE cerebrum:3.39 cerebellum:- brain stem:2.87 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.98 retina:- eye:- artery/aorta:3.15 vein:- lymphnode:4.00 peripheral blood:- spleen:3.40 thymus:3.92 bone marrow:- adipose:- bone:3.64 skin:3.25
RNA-seq cerebrum:1.51 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:151.90 prostate:30.90 ovary:68.90 testis:59.10 heart:37.20 muscle:- esophagus:- stomach:- intestine:37 colon:52.90     liver/hepato:-        lung:50.20    bladder:66.20 kidney:72.50 pituitary:38.80 thyroid/parathyroid:- adrenal gland:- pancreas:65.70 breast:29.40 salivary:54
GeneChip uterus:7.44 placenta:9.15 prostate:7.27 ovary:7.38 testis:7.37 heart:6.32 muscle:6.15 esophagus:- stomach:7.18 intestine:7.34 colon:- liver/hepato:6.97 lung:7.28 bladder:7.35 kidney:6.68 pituitary:7.73 thyroid/parathyroid:- adrenal gland:6.60 pancreas:5.64 breast:7.42 salivary:6.66
CAGE uterus:3.03 placenta:3.30 prostate:3.25 ovary:3.31 testis:3.18 heart:- muscle:- esophagus:- stomach:2.85 intestine:2.98 colon:2.96     liver/hepato:3.15    lung:3.36 bladder:2.97 kidney:- pituitary:3.53 thyroid/parathyroid:- adrenal gland:2.89 pancreas:3.10 breast:3.16 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.05 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.38        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001113354
Gene ID 320595
Unigene ID Mm.17156
Probe set ID 1460398_at  [Mouse430_2]
Ensembl ID ENSMUSG00000041229

Orthologous Gene

Human[1]  NM_001184896, NM_001184897, NM_001184898, NM_015107
Rat[1]  NM_001108253, NM_001106765, NM_001184898, NM_015107

Chromosomal Region

XF3  [147,955,215  -  148,068,402]

Gene Family (Interpro ID)

IPR003347  Transcription factor jumonji/aspartyl beta-hydroxylase
IPR019787  Zinc finger, PHD-finger
IPR001965  Zinc finger, PHD-type

Link to Pubmed  (Pubmed ID)

8889548
10349636
10922068
11042159
11076861
11217851
12466851
12477932
12693553
14610273
14681479
15112104
15618518
15782199
16141072
16141073
16199551
18287559
18799693
20059953
20412781
20548336
21267068
21677750
22850744

Gene Ontology  (GO ID)

Biological Process

GO:0000082  G1/S transition of mitotic cell cycle
GO:0070544  histone H3-K36 demethylation
GO:0033169  histone H3-K9 demethylation
GO:0055114  oxidation reduction
GO:0045943  positive regulation of transcription from RNA polymerase I promoter
GO:0045893  positive regulation of transcription, DNA-dependent

Cellular Component

GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0003682  chromatin binding
GO:0032452  histone demethylase activity
GO:0051864  histone demethylase activity (H3-K36 specific)
GO:0032454  histone demethylase activity (H3-K9 specific)
GO:0005506  iron ion binding
GO:0035064  methylated histone residue binding
GO:0016706  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270  zinc ion binding