exosome component 10

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Synonym

p4, RRP6, Polymyositis/scleroderma autoantigen 2 homolog, Exosc10, Exosome component 10, p2, PM-Scl, p3, Pmscl2, PM/Scl-100, Autoantigen PM/Scl 2 homolog, exosome component 10

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:105.90 cerebellum:239.50 brain stem:222.50 corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:236.40 retina:32.10 eye:45.60 artery/aorta:253.20 vein:- lymphnode:75.60 peripheral blood:230 spleen:26.30 thymus:177.80 bone marrow:115.40 adipose:638.20 bone:112.70 skin:166.30
GeneChip cerebrum:7.66 cerebellum:7.52 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.19 spine:7.55 retina:7.14 eye:7.24 artery/aorta:- vein:7.95 lymphnode:8.47 peripheral blood:- spleen:8.42 thymus:- bone marrow:8.12 adipose:7.75 bone:8.05 skin:7.50
CAGE cerebrum:3.02 cerebellum:- brain stem:2.99 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.95 retina:- eye:- artery/aorta:3.10 vein:- lymphnode:3.79 peripheral blood:- spleen:3.29 thymus:3.38 bone marrow:- adipose:- bone:2.83 skin:3.23
RNA-seq cerebrum:6.62 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:130.90 placenta:27.60 prostate:- ovary:252.80 testis:147.80 heart:74.40 muscle:35.50 esophagus:- stomach:- intestine:73.90 colon:88.10     liver/hepato:54.30        lung:110.50    bladder:132.40 kidney:145.10 pituitary:25.80 thyroid/parathyroid:112.50 adrenal gland:- pancreas:84.40 breast:88.20 salivary:-
GeneChip uterus:8.22 placenta:7.97 prostate:8.05 ovary:8.02 testis:9.18 heart:8.06 muscle:7.87 esophagus:- stomach:7.82 intestine:7.72 colon:- liver/hepato:7.87 lung:7.97 bladder:8.05 kidney:7.90 pituitary:7.81 thyroid/parathyroid:- adrenal gland:7.84 pancreas:7.72 breast:7.73 salivary:7.66
CAGE uterus:3.13 placenta:2.99 prostate:2.90 ovary:3.10 testis:4.79 heart:- muscle:- esophagus:- stomach:2.52 intestine:2.54 colon:2.81     liver/hepato:2.95    lung:3.10 bladder:3.07 kidney:- pituitary:3.06 thyroid/parathyroid:- adrenal gland:2.97 pancreas:2.19 breast:2.96 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.73 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.78        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_016699
Gene ID 50912
Unigene ID Mm.266635
Probe set ID 1423587_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000017264

Orthologous Gene

Human[2]  NM_001001998, NM_002685
Rat[2]  NM_001001998, NM_002685

Chromosomal Region

-

Gene Family (Interpro ID)

IPR002562  3'-5' exonuclease
IPR012337  Polynucleotidyl transferase, ribonuclease H fold

Link to Pubmed  (Pubmed ID)

8889548
10349636
10708524
10922068
11042159
11076861
11217851
11544199
12466851
12477932
12520002
14610273
14634209
15782199
16141072
16141073
16789828
17967808
18799693
21267068
21677750
23918385
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0044237  cellular metabolic process
GO:0071034  CUT catabolic process
GO:0009048  dosage compensation, by inactivation of X chromosome
GO:0071044  histone mRNA catabolic process
GO:0000460  maturation of 5.8S rRNA
GO:0071028  nuclear mRNA surveillance
GO:0071035  nuclear polyadenylation-dependent rRNA catabolic process
GO:0071048  nuclear retention of unspliced pre-mRNA at the site of transcription
GO:0000956  nuclear-transcribed mRNA catabolic process
GO:0000184  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006139  nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0006396  RNA processing
GO:0006364  rRNA processing

Cellular Component

GO:0005737  cytoplasm
GO:0000178  exosome (RNase complex)
GO:0005622  intracellular
GO:0000176  nuclear exosome (RNase complex)
GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0008408  3'-5' exonuclease activity
GO:0003824  catalytic activity
GO:0004527  exonuclease activity
GO:0004532  exoribonuclease activity
GO:0016787  hydrolase activity
GO:0004518  nuclease activity
GO:0003676  nucleic acid binding
GO:0000166  nucleotide binding
GO:0003723  RNA binding