serine/threonine kinase 4

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Synonym

Mst1, Ysk3, STE20-like kinase MST1, Kas-2, Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, MST-1, AU020804, serine/threonine kinase 4, AI447339, Stk4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:123.30 cerebellum:73.70 brain stem:63.60 corpus callosum/glia:- pineal gland:- peripheral nerve:19.10 spine:- retina:64.30 eye:106.40 artery/aorta:- vein:- lymphnode:54 peripheral blood:57.50 spleen:158 thymus:168 bone marrow:192.30 adipose:- bone:- skin:87.10
GeneChip cerebrum:5.33 cerebellum:5.40 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.38 spine:5.11 retina:5.04 eye:5.44 artery/aorta:- vein:5.22 lymphnode:7.67 peripheral blood:- spleen:7.32 thymus:- bone marrow:6.77 adipose:5.40 bone:6.49 skin:5.78
CAGE cerebrum:2.60 cerebellum:- brain stem:2.37 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.11 retina:- eye:- artery/aorta:2.62 vein:- lymphnode:4.69 peripheral blood:- spleen:3.70 thymus:4.50 bone marrow:- adipose:- bone:3.83 skin:3.03
RNA-seq cerebrum:2.68 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:82.80 prostate:30.90 ovary:23 testis:125.60 heart:- muscle:- esophagus:- stomach:- intestine:- colon:35.20     liver/hepato:-        lung:20.10    bladder:66.20 kidney:16.10 pituitary:206.70 thyroid/parathyroid:- adrenal gland:- pancreas:18.80 breast:29.40 salivary:-
GeneChip uterus:5.43 placenta:5.91 prostate:4.60 ovary:5.26 testis:5.86 heart:5.06 muscle:5.08 esophagus:- stomach:5.51 intestine:5.60 colon:- liver/hepato:5.15 lung:6.08 bladder:5.25 kidney:5.41 pituitary:5.16 thyroid/parathyroid:- adrenal gland:5.13 pancreas:5.38 breast:5.29 salivary:5.58
CAGE uterus:2.71 placenta:3.00 prostate:2.11 ovary:2.74 testis:3.00 heart:- muscle:- esophagus:- stomach:2.95 intestine:2.22 colon:2.87     liver/hepato:1.94    lung:4.05 bladder:2.59 kidney:- pituitary:2.45 thyroid/parathyroid:- adrenal gland:2.50 pancreas:2.19 breast:2.71 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.04 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.45        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_021420
Gene ID 58231
Unigene ID Mm.234472
Probe set ID 1421107_at  [Mouse430_2]
Ensembl ID ENSMUSG00000018209

Orthologous Gene

Human[2]  NM_006282
Rat[1]  NM_001107800

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7559398
8889548
9160885
10349636
10512203
10725249
10922068
11042159
11076861
11217851
11278283
11805089
11864565
12223493
12384512
12466851
12477932
12520002
12750396
14610273
15345747
15489334
15741177
15840001
16141072
16141073
16892067
17967808
18287559
18369314
18799693
18942145
19073936
19339990
19692642
19786569
19822666
19878874
19956688
19962960
20080598
20080689
20171103
21376238
21512031
21572393
21677750
21730291
21831922
22042863
22412158
22926556
23033074
23071096
23085515
23374633
23454691
23555292
23620511
23644383
23818595
24040101
24141421
24453252
24457600
24633305

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0060706  cell differentiation involved in embryonic placenta development
GO:0000902  cell morphogenesis
GO:0007417  central nervous system development
GO:0003157  endocardium development
GO:0006917  induction of apoptosis
GO:0030216  keratinocyte differentiation
GO:0008285  negative regulation of cell proliferation
GO:0046621  negative regulation of organ growth
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0001841  neural tube formation
GO:0001569  patterning of blood vessels
GO:0018105  peptidyl-serine phosphorylation
GO:0016310  phosphorylation
GO:0043065  positive regulation of apoptosis
GO:0060215  primitive hemopoiesis
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0007165  signal transduction

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0042802  identical protein binding
GO:0016301  kinase activity
GO:0000287  magnesium ion binding
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0046983  protein dimerization activity
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0043539  protein serine/threonine kinase activator activity
GO:0004674  protein serine/threonine kinase activity
GO:0008134  transcription factor binding
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups