leucine-rich repeat kinase 2

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Synonym

AW561911, Gm927, D630001M17Rik, 9330188B09Rik, leucine-rich repeat kinase 2, Lrrk2, cI-46, 4921513O20Rik

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:7.15 cerebellum:7.16 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.47 spine:6.08 retina:4.80 eye:5.68 artery/aorta:- vein:6.05 lymphnode:8.15 peripheral blood:- spleen:8.50 thymus:- bone marrow:7.92 adipose:5.66 bone:7.80 skin:4.95
CAGE cerebrum:3.02 cerebellum:- brain stem:2.48 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.57 retina:- eye:- artery/aorta:2.41 vein:- lymphnode:4.87 peripheral blood:- spleen:3.73 thymus:1.90 bone marrow:- adipose:- bone:3.57 skin:2.40
RNA-seq cerebrum:4.13 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.93 placenta:4.70 prostate:4.78 ovary:5.80 testis:6.38 heart:6.42 muscle:5.67 esophagus:- stomach:4.92 intestine:5.09 colon:- liver/hepato:4.62 lung:8.87 bladder:6.27 kidney:9.22 pituitary:5.79 thyroid/parathyroid:- adrenal gland:6.24 pancreas:5.27 breast:5.52 salivary:4.59
CAGE uterus:1.98 placenta:1.49 prostate:1.35 ovary:2.88 testis:1.89 heart:- muscle:- esophagus:- stomach:0.67 intestine:1.29 colon:1.40     liver/hepato:1.38    lung:4.44 bladder:2.99 kidney:- pituitary:2.50 thyroid/parathyroid:- adrenal gland:2.74 pancreas:1.61 breast:1.73 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.32 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.15        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_025730
Gene ID 66725
Unigene ID Mm.375584
Probe set ID 1431394_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000036273

Orthologous Gene

Human[1]  NM_198578
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR013753  Ras
IPR001806  Ras GTPase
IPR003579  Ras small GTPase, Rab type
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR005225  Small GTP-binding protein
IPR020851  Small GTPase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

10349636
11004510
11042159
11076861
11217851
12466851
12477932
15489334
15541309
16141072
16141073
16487147
16504409
16532471
16771836
16980962
17101029
17114044
17341485
17623048
18045479
18367605
18445495
18790059
19142648
19176810
19196961
19536328
19545277
19667187
19740074
19890007
20016100
20064389
20079710
20130188
20146535
20403420
20457918
20595391
20642453
20659021
20728949
20729864
20850369
20876399
20949042
21048939
21168496
21307259
21370995
21390248
21677750
21695257
21828077
21857923
21972245
21983832
22080837
22166428
22230652
22253261
22302802
22357653
22363216
22423108
22496842
22539006
22612223
22615783
22639965
22647713
22713584
22736029
22850484
22899650
22952686
22988862
23082216
23125283
23183827
23231918
23241745
23270607
23318930
23526378
23600457
23646112
23675505
23936174
23937259
23949442
24046356
24113872
24167564
24275654
24282027
24464040
24687852

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0000186  activation of MAPKK activity
GO:0006914  autophagy
GO:0008340  determination of adult lifespan
GO:0006184  GTP catabolic process
GO:0048312  intracellular distribution of mitochondria
GO:0000165  MAPKKK cascade
GO:0034260  negative regulation of GTPase activity
GO:0007406  negative regulation of neuroblast proliferation
GO:0014043  negative regulation of neuron maturation
GO:0007528  neuromuscular junction development
GO:0070997  neuron death
GO:0021772  olfactory bulb development
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0016310  phosphorylation
GO:0010508  positive regulation of autophagy
GO:0010942  positive regulation of cell death
GO:0060161  positive regulation of dopamine receptor signaling pathway
GO:0043547  positive regulation of GTPase activity
GO:0043068  positive regulation of programmed cell death
GO:0032436  positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0031398  positive regulation of protein ubiquitination
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0040012  regulation of locomotion
GO:0042391  regulation of membrane potential
GO:0006979  response to oxidative stress
GO:0007264  small GTPase mediated signal transduction
GO:0022028  tangential migration from the subventricular zone to the olfactory bulb

Cellular Component

GO:0030424  axon
GO:0043025  cell soma
GO:0005737  cytoplasm
GO:0030425  dendrite
GO:0032839  dendrite cytoplasm
GO:0032473  external side of mitochondrial outer membrane
GO:0005622  intracellular
GO:0043231  intracellular membrane-bounded organelle
GO:0016020  membrane
GO:0045121  membrane raft
GO:0005739  mitochondrion
GO:0043005  neuron projection
GO:0005886  plasma membrane
GO:0045202  synapse
GO:0008021  synaptic vesicle
GO:0005802  trans-Golgi network

Molecular Function

GO:0005524  ATP binding
GO:0005525  GTP binding
GO:0034211  GTP-dependent protein kinase activity
GO:0005096  GTPase activator activity
GO:0003924  GTPase activity
GO:0042802  identical protein binding
GO:0016301  kinase activity
GO:0004708  MAP kinase kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0017048  Rho GTPase binding
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0015631  tubulin binding