ubiquitin protein ligase E3 component n-recognin 5

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Synonym

AW549941, Kiaa0896, mKIAA0896, 4432411E13Rik, C77315, D030042K14, Edd, Hyperplastic discs protein homolog, Edd1, Ubiquitin-protein ligase EDD1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:161.50 cerebellum:73.70 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:19.10 spine:47.30 retina:160.70 eye:349.50 artery/aorta:- vein:- lymphnode:- peripheral blood:71.90 spleen:- thymus:19.80 bone marrow:12.80 adipose:425.40 bone:100.20 skin:71.30
GeneChip cerebrum:10.29 cerebellum:10.48 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:10.45 spine:9.98 retina:10.19 eye:9.83 artery/aorta:- vein:10.21 lymphnode:10.43 peripheral blood:- spleen:10.28 thymus:- bone marrow:10.05 adipose:10.21 bone:10.22 skin:10.75
CAGE cerebrum:3.65 cerebellum:- brain stem:3.56 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.57 retina:- eye:- artery/aorta:3.65 vein:- lymphnode:2.43 peripheral blood:- spleen:3.45 thymus:3.59 bone marrow:- adipose:- bone:3.59 skin:3.84
RNA-seq cerebrum:6.07 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:87.20 placenta:41.40 prostate:30.90 ovary:34.50 testis:399 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:45.30        lung:70.30    bladder:- kidney:48.40 pituitary:12.90 thyroid/parathyroid:- adrenal gland:424.40 pancreas:131.40 breast:75.10 salivary:-
GeneChip uterus:10.55 placenta:10.63 prostate:10.40 ovary:10.79 testis:11.64 heart:10.68 muscle:10.69 esophagus:- stomach:10.22 intestine:10.32 colon:- liver/hepato:10.04 lung:10.36 bladder:10.48 kidney:10.27 pituitary:10.76 thyroid/parathyroid:- adrenal gland:10.60 pancreas:9.96 breast:10.30 salivary:10.40
CAGE uterus:3.64 placenta:3.70 prostate:3.50 ovary:3.78 testis:5.37 heart:- muscle:- esophagus:- stomach:2.66 intestine:3.55 colon:3.58     liver/hepato:3.75    lung:3.72 bladder:3.60 kidney:- pituitary:3.76 thyroid/parathyroid:- adrenal gland:3.71 pancreas:3.61 breast:3.35 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.07 esophagus:- stomach:- intestine:- colon:-     liver/hepato:7.37        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001081359
Gene ID 70790
Unigene ID Mm.275426
Probe set ID 1452718_at  [Mouse430_2]
Ensembl ID ENSMUSG00000037487

Orthologous Gene

Human[3]  NM_015902
Rat[3]  NM_015902

Chromosomal Region

15B3.1  [37,897,083  -  38,008,608]

Gene Family (Interpro ID)

IPR003126  Zinc finger, N-recognin
IPR013993  Zinc finger, N-recognin, metazoa

Link to Pubmed  (Pubmed ID)

8889548
10349636
10725249
10922068
11042159
11076861
11217851
11752298
12011095
12466851
12477932
12520002
12693553
12904583
14610273
15282321
15489334
16141072
16141073
17967808
18076571
18162545
18799693
19008229
20167605
20360068
21267068
21677750
21726813
22033112
22695613
23326633

Gene Ontology  (GO ID)

Biological Process

GO:0006281  DNA repair
GO:0033160  positive regulation of protein import into nucleus, translocation
GO:0050847  progesterone receptor signaling pathway
GO:0000209  protein polyubiquitination
GO:0042787  protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0006974  response to DNA damage stimulus

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0016874  ligase activity
GO:0046872  metal ion binding
GO:0003723  RNA binding
GO:0043130  ubiquitin binding
GO:0004842  ubiquitin-protein ligase activity
GO:0034450  ubiquitin-ubiquitin ligase activity
GO:0008270  zinc ion binding