ribosomal protein S6 kinase, polypeptide 5

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Synonym

6330404E13Rik, Msk1, RSK-like protein kinase, RLPK, Ribosomal protein S6 kinase alpha-5, RLSK, 3110005L17Rik, Rps6ka5, MSK1, MSPK1, AI854034, MGC28385, ribosomal protein S6 kinase, polypeptide 5, 90 kDa ribosomal protein S6 kinase 5

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:26 cerebellum:- brain stem:31.80 corpus callosum/glia:- pineal gland:257.80 peripheral nerve:- spine:- retina:- eye:45.60 artery/aorta:- vein:- lymphnode:- peripheral blood:28.80 spleen:26.30 thymus:49.40 bone marrow:12.80 adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:2.57 cerebellum:- brain stem:2.29 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.64 retina:- eye:- artery/aorta:2.75 vein:- lymphnode:2.87 peripheral blood:- spleen:2.33 thymus:2.46 bone marrow:- adipose:- bone:2.09 skin:2.15
RNA-seq cerebrum:1.92 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:13.80 prostate:- ovary:46 testis:14.80 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:30.10    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:28.10 breast:6.50 salivary:-
GeneChip nodata
CAGE uterus:1.46 placenta:1.18 prostate:1.09 ovary:2.02 testis:1.18 heart:- muscle:- esophagus:- stomach:1.57 intestine:2.56 colon:2.03     liver/hepato:1.12    lung:1.62 bladder:1.83 kidney:- pituitary:3.10 thyroid/parathyroid:- adrenal gland:1.82 pancreas:0.84 breast:1.74 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.37 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.45        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_153587
Gene ID 73086
Unigene ID Mm.220417
Probe set ID -
Ensembl ID ENSMUSG00000021180

Orthologous Gene

Human[3]  NM_004755, NM_182398
Rat[1]  NM_001108048, NM_182398

Chromosomal Region

12E  [101,787,988  -  101,963,238]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8889548
9687510
10349636
10922068
11018520
11042159
11076861
11125038
11217851
11441012
11909979
12466851
12477932
12520002
12628924
12769834
12773393
14610273
15128846
15192015
15327773
15489334
15496409
15681159
15870105
15893597
16141072
16141073
16339038
16517600
16728397
16762916
17081988
17196532
17668895
17906627
17967808
18003853
18029446
18513320
18690222
18799693
19015318
19078967
19158668
19224920
19922413
20129940
20164464
20303596
20307261
20362473
21071437
21106525
21166721
21267068
21314333
21493629
21677750
21924255
21970321
22004609
22312446
22733812
22993422
23020821
23077336
23127194
23241891
23382072
23533666
23619911
23658634
23719381
23831393
23979601

Gene Ontology  (GO ID)

Biological Process

GO:0043990  histone H2A-S1 phosphorylation
GO:0043987  histone H3-S10 phosphorylation
GO:0043988  histone H3-S28 phosphorylation
GO:0016572  histone phosphorylation
GO:0006954  inflammatory response
GO:0070498  interleukin-1-mediated signaling pathway
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0016310  phosphorylation
GO:0035066  positive regulation of histone acetylation
GO:0033129  positive regulation of histone phosphorylation
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0006355  regulation of transcription, DNA-dependent
GO:0006950  response to stress

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0000287  magnesium ion binding
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups