amyotrophic lateral sclerosis 2 (juvenile) homolog (human)

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Synonym

Als2cr6, 9430073A21Rik, Amyotrophic lateral sclerosis protein 2 homolog, MGC27807, 3222402C23Rik, Als2, mKIAA1563, Alsin

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:99 cerebellum:73.70 brain stem:63.60 corpus callosum/glia:- pineal gland:- peripheral nerve:114.70 spine:- retina:32.10 eye:114 artery/aorta:- vein:- lymphnode:140.40 peripheral blood:100.60 spleen:105.30 thymus:69.20 bone marrow:12.80 adipose:- bone:- skin:31.70
GeneChip cerebrum:7.74 cerebellum:10.64 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.79 spine:7.59 retina:8.66 eye:7.35 artery/aorta:- vein:6.52 lymphnode:7.11 peripheral blood:- spleen:7.02 thymus:- bone marrow:6.69 adipose:7.08 bone:6.66 skin:6.74
CAGE cerebrum:3.69 cerebellum:- brain stem:2.43 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.54 retina:- eye:- artery/aorta:2.19 vein:- lymphnode:2.08 peripheral blood:- spleen:1.63 thymus:2.80 bone marrow:- adipose:- bone:2.09 skin:2.37
RNA-seq cerebrum:4.08 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:110.50 prostate:30.90 ovary:34.50 testis:59.10 heart:18.60 muscle:35.50 esophagus:- stomach:- intestine:- colon:-     liver/hepato:63.40        lung:40.20    bladder:66.20 kidney:8.10 pituitary:51.70 thyroid/parathyroid:- adrenal gland:424.40 pancreas:112.60 breast:45.70 salivary:-
GeneChip uterus:6.83 placenta:8.03 prostate:6.74 ovary:6.82 testis:7.14 heart:6.92 muscle:7.93 esophagus:- stomach:6.83 intestine:7.08 colon:- liver/hepato:9.48 lung:7.03 bladder:6.87 kidney:8.10 pituitary:6.99 thyroid/parathyroid:- adrenal gland:6.83 pancreas:7.20 breast:7.01 salivary:6.58
CAGE uterus:1.95 placenta:2.60 prostate:1.41 ovary:1.94 testis:0.99 heart:- muscle:- esophagus:- stomach:1.57 intestine:2.67 colon:3.12     liver/hepato:3.82    lung:1.76 bladder:1.80 kidney:- pituitary:1.96 thyroid/parathyroid:- adrenal gland:2.04 pancreas:1.84 breast:2.15 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:7.68 esophagus:- stomach:- intestine:- colon:-     liver/hepato:5.04        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001159948
Gene ID 74018
Unigene ID Mm.272078
Probe set ID 1417783_at  [Mouse430_2]
Ensembl ID ENSMUSG00000026024

Orthologous Gene

Human[4]  NM_001135745, NM_020919
Rat[1]  NM_001013413, NM_020919

Chromosomal Region

1C1.3  [59,219,770  -  59,294,075]

Gene Family (Interpro ID)

IPR003123  Vacuolar sorting protein 9

Link to Pubmed  (Pubmed ID)

8889548
10349636
10922068
11042159
11076861
11217851
11544199
11586298
12466851
12477932
12520002
12693553
12787792
14610273
14691545
15033976
15489334
15579468
16085057
16107644
16141072
16141073
16240357
16321985
16602821
16769894
16802286
16802292
16973244
17015433
17093100
17156857
17239822
17409386
17855450
17955197
18358238
18558633
18799693
19304783
19563800
19630956
20339559
20558214
21267068
21677750
21907703
21937428
22438926
22982304

Gene Ontology  (GO ID)

Biological Process

GO:0007409  axonogenesis
GO:0001662  behavioral fear response
GO:0008219  cell death
GO:0007032  endosome organization
GO:0016197  endosome transport
GO:0007626  locomotory behavior
GO:0007041  lysosomal transport
GO:0007528  neuromuscular junction development
GO:0048812  neuron projection morphogenesis
GO:0045860  positive regulation of protein kinase activity
GO:0032855  positive regulation of Rac GTPase activity
GO:0051260  protein homooligomerization
GO:0008104  protein localization
GO:0016601  Rac protein signal transduction
GO:0001881  receptor recycling
GO:0032313  regulation of Rab GTPase activity
GO:0035023  regulation of Rho protein signal transduction
GO:0006979  response to oxidative stress
GO:0035249  synaptic transmission, glutamatergic
GO:0016050  vesicle organization

Cellular Component

GO:0030424  axon
GO:0043025  cell soma
GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030425  dendrite
GO:0043197  dendritic spine
GO:0005769  early endosome
GO:0030426  growth cone
GO:0043231  intracellular membrane-bounded organelle
GO:0030027  lamellipodium
GO:0016020  membrane
GO:0043005  neuron projection
GO:0005634  nucleus
GO:0014069  postsynaptic density
GO:0043234  protein complex
GO:0001726  ruffle
GO:0031982  vesicle

Molecular Function

GO:0005085  guanyl-nucleotide exchange factor activity
GO:0042802  identical protein binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0043539  protein serine/threonine kinase activator activity
GO:0005097  Rab GTPase activator activity
GO:0017137  Rab GTPase binding
GO:0017112  Rab guanyl-nucleotide exchange factor activity
GO:0030675  Rac GTPase activator activity
GO:0048365  Rac GTPase binding
GO:0030676  Rac guanyl-nucleotide exchange factor activity
GO:0005089  Rho guanyl-nucleotide exchange factor activity