fms-related tyrosine kinase 4

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:78 thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:79.60 prostate:- ovary:- testis:- heart:19.40 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:50.70    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_053652
Gene ID 114110
Unigene ID Rn.81043
Probe set ID -
Ensembl ID ENSRNOG00000002511

Orthologous Gene

Human[2]  NM_002020, NM_182925
Mouse[2]  NM_008029, NM_182925

Chromosomal Region

10q22  [35,071,002  -  35,112,006]

Gene Family (Interpro ID)

IPR000565  DNA topoisomerase, type IIA, subunit B
IPR013106  Immunoglobulin V-set
IPR003596  Immunoglobulin V-set, subgroup
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain
IPR009134  Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal
IPR009135  Tyrosine-protein kinase, vascular endothelial growth factor receptor 1 (VEGFR1), N-terminal
IPR009136  Tyrosine-protein kinase, vascular endothelial growth factor receptor 2 (VEGFR2)
IPR009137  Tyrosine-protein kinase, vascular endothelial growth factor receptor 3 (VEGFR3), N-terminal

Link to Pubmed  (Pubmed ID)

7898938
10878616
11683876
15563310
17584927
19196316
19901262
19963036
20127810
20572782
20692049
21072582
21703344
21865112
22170007
22771250
22818386
22959907
22983493
24379135

Gene Ontology  (GO ID)

Biological Process

GO:0048514  blood vessel morphogenesis
GO:0001945  lymph vessel development
GO:0001946  lymphangiogenesis
GO:0043066  negative regulation of apoptosis
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0030307  positive regulation of cell growth
GO:0008284  positive regulation of cell proliferation
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0046330  positive regulation of JNK cascade
GO:0043410  positive regulation of MAPKKK cascade
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0090037  positive regulation of protein kinase C signaling cascade
GO:0010575  positive regulation vascular endothelial growth factor production
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0060312  regulation of blood vessel remodeling
GO:0002040  sprouting angiogenesis
GO:0048010  vascular endothelial growth factor receptor signaling pathway
GO:0001944  vasculature development

Cellular Component

GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0019903  protein phosphatase binding
GO:0004714  transmembrane receptor protein tyrosine kinase activity
GO:0005021  vascular endothelial growth factor receptor activity