Rho guanine nucleotide exchange factor (GEF7)

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:83.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:35.50 artery/aorta:714.30 vein:- lymphnode:- peripheral blood:- spleen:156 thymus:122.90 bone marrow:- adipose:147.20 bone:78.10 skin:-
GeneChip cerebrum:3.64 cerebellum:3.59 brain stem:3.68 corpus callosum/glia:- pineal gland:- peripheral nerve:3.35 spine:- retina:- eye:4 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:3.42 thymus:3.41 bone marrow:3.43 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:1139 placenta:39.80 prostate:113.90 ovary:- testis:- heart:213.30 muscle:- esophagus:- stomach:- intestine:314 colon:-     liver/hepato:-        lung:50.70    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:113.80 breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:3.58 muscle:3.66 esophagus:- stomach:- intestine:3.39 colon:3.41 liver/hepato:- lung:- bladder:- kidney:3.38 pituitary:3.51 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001113522
Gene ID 114559
Unigene ID Rn.146763
Probe set ID rc_AA874918_at  [RG_U34A]
Ensembl ID ENSRNOG00000012934

Orthologous Gene

Human[7]  NM_001113511, NM_001113512, NM_001113513, NM_003899, NM_145735
Mouse[3]  NM_001113517, NM_001113518, NM_017402, NM_003899, NM_145735

Chromosomal Region

16q12.5  [82,521,226  -  82,635,476]

Gene Family (Interpro ID)

IPR001997  Calponin
IPR016146  Calponin-homology
IPR001715  Calponin-like actin-binding
IPR001849  Pleckstrin homology
IPR003096  SM22/calponin
IPR013315  Spectrin alpha chain, SH3 domain
IPR020473  Src homology-3, region

Link to Pubmed  (Pubmed ID)

8889548
9659915
10896954
11950598
12226077
12477932
12626503
16527308
16795052
16954223
17081755
18385518
19136011
19322025
20117114
20338996
21088884
22114281

Gene Ontology  (GO ID)

Biological Process

GO:0043615  astrocyte cell migration
GO:0030032  lamellipodium assembly
GO:0043065  positive regulation of apoptosis
GO:0043547  positive regulation of GTPase activity
GO:0035023  regulation of Rho protein signal transduction
GO:0007264  small GTPase mediated signal transduction

Cellular Component

GO:0005938  cell cortex
GO:0043025  cell soma
GO:0005737  cytoplasm
GO:0005925  focal adhesion
GO:0030426  growth cone
GO:0005622  intracellular
GO:0030027  lamellipodium
GO:0043005  neuron projection
GO:0043234  protein complex
GO:0001726  ruffle

Molecular Function

GO:0005085  guanyl-nucleotide exchange factor activity
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0005089  Rho guanyl-nucleotide exchange factor activity