bone morphogenetic protein receptor, type II (serine/threonine kinase)

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:95.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:36.90 spine:- retina:- eye:71.10 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:117.10 skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:79.60 prostate:38 ovary:- testis:- heart:38.80 muscle:- esophagus:- stomach:- intestine:104.70 colon:-     liver/hepato:-        lung:101.30    bladder:- kidney:63.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID XM_217409
Gene ID 140590
Unigene ID Rn.59276
Probe set ID -
Ensembl ID -

Orthologous Gene

Human [0]  
Mouse [0]  

Chromosomal Region

9q31  [58,377,424  -  58,435,742]

Gene Family (Interpro ID)

IPR000333  Activin type II receptor
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8854897
9080432
9626398
10482474
10996456
11044210
15775752
16271518
16361357
18063682
18292470
18367643
18663089
18723761
19153267
19324947
19440953
19669850
19785764
20002458
20534176
21070126
21185359
21521772
21619414
23079343
23446737

Gene Ontology  (GO ID)

Biological Process

GO:0009952  anterior/posterior pattern formation
GO:0060840  artery development
GO:0001974  blood vessel remodeling
GO:0030509  BMP signaling pathway
GO:0007420  brain development
GO:0009267  cellular response to starvation
GO:0048286  lung alveolus development
GO:0001946  lymphangiogenesis
GO:0060836  lymphatic endothelial cell differentiation
GO:0001707  mesoderm formation
GO:0030308  negative regulation of cell growth
GO:0003085  negative regulation of systemic arterial blood pressure
GO:0045906  negative regulation of vasoconstriction
GO:0030513  positive regulation of BMP signaling pathway
GO:0030501  positive regulation of bone mineralization
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0010634  positive regulation of epithelial cell migration
GO:0045669  positive regulation of osteoblast differentiation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0042127  regulation of cell proliferation
GO:0014916  regulation of lung blood pressure
GO:0060041  retina development in camera-type eye
GO:0006366  transcription from RNA polymerase II promoter
GO:0007178  transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0048010  vascular endothelial growth factor receptor signaling pathway
GO:0060841  venous blood vessel development

Cellular Component

GO:0016324  apical plasma membrane
GO:0009925  basal plasma membrane
GO:0005901  caveola
GO:0043025  cell soma
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0030425  dendrite
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0005024  transforming growth factor beta receptor activity
GO:0004675  transmembrane receptor protein serine/threonine kinase activity