cystic fibrosis transmembrane conductance regulator homolog (human)

 jump to detail

Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:35.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:7.01 cerebellum:7.03 brain stem:7.01 corpus callosum/glia:- pineal gland:- peripheral nerve:6.72 spine:- retina:- eye:7.10 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:6.83 thymus:6.85 bone marrow:7.06 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:289.90     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:6.78 muscle:6.95 esophagus:- stomach:- intestine:6.71 colon:6.63 liver/hepato:- lung:- bladder:- kidney:6.85 pituitary:6.89 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_031506
Gene ID 24255
Unigene ID Rn.124539
Probe set ID M89906_at  [RG_U34A]
Ensembl ID ENSRNOG00000008284

Orthologous Gene

Human[6]  NM_000492
Mouse[2]  NM_021050

Chromosomal Region

4q21  [43,874,852  -  44,041,870]

Gene Family (Interpro ID)

IPR017940  ABC transporter integral membrane type 1
IPR001140  ABC transporter, transmembrane domain
IPR011527  ABC transporter, transmembrane domain, type 1
IPR003439  ABC transporter-like
IPR003593  ATPase, AAA+ type, core
IPR005291  Cyclic AMP-dependent chloride channel
IPR009147  Cystic fibrosis transmembrane conductance regulator

Link to Pubmed  (Pubmed ID)

1282491
1283149
1284535
1370365
1379413
1380723
1380943
1381442
2344617
7521937
7526924
7539891
7543317
7560099
8535440
9100367
9254853
9272157
9429141
9439669
10767489
11083465
11243954
11504703
11707776
11719459
11732487
11773581
11823443
11937500
12110684
12123489
12403779
14679199
14975182
15020588
15107294
15463907
15605366
15694001
15781764
15872007
15905414
16051669
16051699
16227367
16311240
16575514
16614390
16678503
16804061
16859673
16916328
17072959
17099022
17122162
17194447
17546509
17595518
17596272
17902144
17916355
18040894
18055461
18057956
18156603
18337312
18420826
18450781
18584958
18652532
18652671
18703788
18769035
18850051
18988797
19202204
19244346
19620404
19657734
19684200
19843100
19858235
19880712
19952026
20015999
20298391
20351096
20722470
20819945
20844248
20974851
21063094
21151921
21185916
21308994
21625623
22293084
22424353
22777528
23221371
23226244
23226939
23645634
24657265

Gene Ontology  (GO ID)

Biological Process

GO:0015701  bicarbonate transport
GO:0007589  body fluid secretion
GO:0071320  cellular response to cAMP
GO:0032870  cellular response to hormone stimulus
GO:0006821  chloride transport
GO:0006695  cholesterol biosynthetic process
GO:0030301  cholesterol transport
GO:0051454  intracellular pH elevation
GO:0015705  iodide transport
GO:0030324  lung development
GO:0060081  membrane hyperpolarization
GO:0045909  positive regulation of vasodilation
GO:0034097  response to cytokine stimulus
GO:0042493  response to drug
GO:0043627  response to estrogen stimulus
GO:0043434  response to peptide hormone stimulus
GO:0048240  sperm capacitation
GO:0030321  transepithelial chloride transport
GO:0042311  vasodilation
GO:0006833  water transport

Cellular Component

GO:0016324  apical plasma membrane
GO:0016323  basolateral plasma membrane
GO:0009986  cell surface
GO:0034707  chloride channel complex
GO:0005737  cytoplasm
GO:0030659  cytoplasmic vesicle membrane
GO:0005769  early endosome
GO:0031901  early endosome membrane
GO:0031205  endoplasmic reticulum Sec complex
GO:0005902  microvillus
GO:0005886  plasma membrane
GO:0043234  protein complex

Molecular Function

GO:0005524  ATP binding
GO:0015106  bicarbonate transmembrane transporter activity
GO:0005260  channel-conductance-controlling ATPase activity
GO:0005254  chloride channel activity
GO:0019869  chloride channel inhibitor activity
GO:0015108  chloride transmembrane transporter activity
GO:0019899  enzyme binding
GO:0003674  molecular_function
GO:0030165  PDZ domain binding