phospholipase C, beta 1 (phosphoinositide-specific)

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:71.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:71.10 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:38 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:101.30    bladder:- kidney:- pituitary:59.20 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip nodata
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001077641
Gene ID 24654
Unigene ID Rn.45523
Probe set ID -
Ensembl ID ENSRNOG00000004810

Orthologous Gene

Human[6]  NM_015192, NM_182734
Mouse[5]  NM_001145830, NM_019677

Chromosomal Region

3q36  [122,799,444  -  123,525,276]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR018029  C2 membrane targeting protein
IPR011992  EF-hand-like domain
IPR015359  Phospholipase C, phosphoinositol-specific, EF-hand-like

Link to Pubmed  (Pubmed ID)

3390863
7510682
8454637
9521338
11161216
11377826
11395409
11976386
12612139
12704654
12786971
12850505
15159145
15240149
15254758
15536495
15782111
16763092
17065107
17524618
18390926
18692062
18694821
18820027
19347873
19538471
19564249
19896516
20393598
21124736
21148417
21338571
22735577
22871113
23665500

Gene Ontology  (GO ID)

Biological Process

GO:0060466  activation of meiosis involved in egg activation
GO:0021987  cerebral cortex development
GO:0045444  fat cell differentiation
GO:0000086  G2/M transition of mitotic cell cycle
GO:0007215  glutamate signaling pathway
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0070498  interleukin-1-mediated signaling pathway
GO:0007612  learning
GO:0016042  lipid catabolic process
GO:0007613  memory
GO:0007213  muscarinic acetylcholine receptor signaling pathway
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0046488  phosphatidylinositol metabolic process
GO:0048639  positive regulation of developmental growth
GO:0040019  positive regulation of embryonic development
GO:0043547  positive regulation of GTPase activity
GO:0032735  positive regulation of interleukin-12 production
GO:0046330  positive regulation of JNK cascade
GO:0045663  positive regulation of myoblast differentiation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0008277  regulation of G-protein coupled receptor protein signaling pathway
GO:0034284  response to monosaccharide stimulus
GO:0010243  response to organic nitrogen
GO:0043434  response to peptide hormone stimulus

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016020  membrane
GO:0000790  nuclear chromatin
GO:0031965  nuclear membrane
GO:0016607  nuclear speck
GO:0005634  nucleus

Molecular Function

GO:0005509  calcium ion binding
GO:0005516  calmodulin binding
GO:0019899  enzyme binding
GO:0005096  GTPase activator activity
GO:0005521  lamin binding
GO:0005546  phosphatidylinositol-4,5-bisphosphate binding
GO:0004435  phosphoinositide phospholipase C activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004871  signal transducer activity