nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

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Synonym

-

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:234 thymus:- bone marrow:- adipose:- bone:195.20 skin:-
GeneChip cerebrum:5.95 cerebellum:6.19 brain stem:5.85 corpus callosum/glia:- pineal gland:- peripheral nerve:6.18 spine:- retina:- eye:6.53 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:7.69 thymus:7.37 bone marrow:6.50 adipose:- bone:- skin:-
CAGE nodata
RNA-seq nodata
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:159.30 prostate:75.90 ovary:228.20 testis:- heart:58.20 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:39.90        lung:152    bladder:- kidney:127.60 pituitary:118.40 thyroid/parathyroid:- adrenal gland:- pancreas:455.20 breast:- salivary:-
GeneChip uterus:- placenta:- prostate:- ovary:- testis:- heart:6.98 muscle:6.90 esophagus:- stomach:- intestine:7.03 colon:7.18 liver/hepato:- lung:- bladder:- kidney:6.73 pituitary:6.17 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
CAGE nodata
RNA-seq nodata

Gene Information

IDs

Refseq ID NM_001105720
Gene ID 25493
Unigene ID Rn.12550
Probe set ID X63594cds_g_at  [RG_U34A]
Ensembl ID ENSRNOG00000007390

Orthologous Gene

Human[1]  NM_020529
Mouse[3]  NM_010907

Chromosomal Region

6q23  [75,729,305  -  75,732,475]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1588976
1741294
8889548
9343439
9918814
10340377
10556199
10620707
10841371
11058855
11493922
12200125
12377412
12477932
12672265
12700242
12897149
14764603
15198731
15308505
15777848
15946255
16006567
16081881
16135962
16540234
16580131
16875840
16928772
16938483
17492467
17878344
18267068
18278452
22022389
22848609
23328071
23374966
23418625

Gene Ontology  (GO ID)

Biological Process

GO:0007253  cytoplasmic sequestering of NF-kappaB
GO:0042994  cytoplasmic sequestering of transcription factor
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0010888  negative regulation of lipid storage
GO:0010745  negative regulation of macrophage derived foam cell differentiation
GO:0045638  negative regulation of myeloid cell differentiation
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0045746  negative regulation of Notch signaling pathway
GO:0070427  nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431  nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0032270  positive regulation of cellular protein metabolic process
GO:0010875  positive regulation of cholesterol efflux
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0000060  protein import into nucleus, translocation
GO:0042127  regulation of cell proliferation
GO:0043330  response to exogenous dsRNA
GO:0032496  response to lipopolysaccharide
GO:0032495  response to muramyl dipeptide
GO:0034142  toll-like receptor 4 signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0033256  I-kappaB/NF-kappaB complex
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0043234  protein complex

Molecular Function

GO:0019899  enzyme binding
GO:0031072  heat shock protein binding
GO:0042802  identical protein binding
GO:0051059  NF-kappaB binding
GO:0008139  nuclear localization sequence binding
GO:0032403  protein complex binding
GO:0031625  ubiquitin protein ligase binding